Literature DB >> 24115690

Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy.

Andrew J Coughlin1, Jeyarama S Ananta, Nanfu Deng, Irina V Larina, Paolo Decuzzi, Jennifer L West.   

Abstract

Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium-nanoshells for image-guided photothermal ablation.
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  X-ray imaging; gold-silica nanoshells; magnetic resonance imaging; optical imaging; photothermal ablation

Mesh：

Substances：

Year:  2013        PMID： 24115690      PMCID： PMC3972071          DOI： 10.1002/smll.201302217

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


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