M J Luque1, J L Tapia2, L Villarroel3, G Marshall4, G Musante5, W Carlo6, J Kattan2. 1. Division de Pediatria, Hospital Clinico Pontificia Universidad Catolica de Chile, Santiago, Chile. 2. Seccion de Neonatologia, Hospital Clinico Pontificia Universidad Catolica de Chile, Santiago, Chile. 3. Departamento Salud Publica, Pontificia Universidad Catolica, Santiago, Chile. 4. Facultad de Matematicas, Pontificia Universidad Catolica, Santiago, Chile. 5. Servicio de Neonatologia, Hospital Universitario Austral, Pilar, Argentina. 6. Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Abstract
OBJECTIVE: Develop a risk prediction model for severe intraventricular hemorrhage (IVH) in very low birth weight infants (VLBWI). STUDY DESIGN: Prospectively collected data of infants with birth weight 500 to 1249 g born between 2001 and 2010 in centers from the Neocosur Network were used. Forward stepwise logistic regression model was employed. The model was tested in the 2011 cohort and then applied to the population of VLBWI that received prophylactic indomethacin to analyze its effect in the risk of severe IVH. RESULT: Data from 6538 VLBWI were analyzed. The area under ROC curve for the model was 0.79 and 0.76 when tested in the 2011 cohort. The prophylactic indomethacin group had lower incidence of severe IVH, especially in the highest-risk groups. CONCLUSION: A model for early severe IVH prediction was developed and tested in our population. Prophylactic indomethacin was associated with a lower risk-adjusted incidence of severe IVH.
OBJECTIVE: Develop a risk prediction model for severe intraventricular hemorrhage (IVH) in very low birth weight infants (VLBWI). STUDY DESIGN: Prospectively collected data of infants with birth weight 500 to 1249 g born between 2001 and 2010 in centers from the Neocosur Network were used. Forward stepwise logistic regression model was employed. The model was tested in the 2011 cohort and then applied to the population of VLBWI that received prophylactic indomethacin to analyze its effect in the risk of severe IVH. RESULT: Data from 6538 VLBWI were analyzed. The area under ROC curve for the model was 0.79 and 0.76 when tested in the 2011 cohort. The prophylactic indomethacin group had lower incidence of severe IVH, especially in the highest-risk groups. CONCLUSION: A model for early severe IVH prediction was developed and tested in our population. Prophylactic indomethacin was associated with a lower risk-adjusted incidence of severe IVH.
Authors: Shannon E G Hamrick; Steven P Miller; Carol Leonard; David V Glidden; Ruth Goldstein; Vijay Ramaswamy; Robert Piecuch; Donna M Ferriero Journal: J Pediatr Date: 2004-11 Impact factor: 4.406
Authors: L R Ment; B Vohr; W Allan; M Westerveld; S S Sparrow; K C Schneider; K H Katz; C C Duncan; R W Makuch Journal: Pediatrics Date: 2000-03 Impact factor: 7.124
Authors: J M Guzmán Cabañas; M J Párraga Quiles; N del Prado; M D Ruíz; M García Del Río; F Benito Zaballo; C Fernández; J Figueras Aloy Journal: An Pediatr (Barc) Date: 2009-08 Impact factor: 1.500
Authors: Dwight J Rouse; Deborah G Hirtz; Elizabeth Thom; Michael W Varner; Catherine Y Spong; Brian M Mercer; Jay D Iams; Ronald J Wapner; Yoram Sorokin; James M Alexander; Margaret Harper; John M Thorp; Susan M Ramin; Fergal D Malone; Marshall Carpenter; Menachem Miodovnik; Atef Moawad; Mary J O'Sullivan; Alan M Peaceman; Gary D V Hankins; Oded Langer; Steve N Caritis; James M Roberts Journal: N Engl J Med Date: 2008-08-28 Impact factor: 91.245
Authors: Elizabeth E Foglia; Robin S Roberts; Jason Z Stoller; Peter G Davis; Ross Haslam; Barbara Schmidt Journal: Neonatology Date: 2017-12-20 Impact factor: 4.035
Authors: Sanjay Chawla; Girija Natarajan; Abbot R Laptook; Dhuly Chowdhury; Edward F Bell; Namasivayam Ambalavanan; Waldemar A Carlo; Marie Gantz; Abhik Das; Jose L Tapia; Heidi M Harmon; Seetha Shankaran Journal: Pediatr Res Date: 2022-03-17 Impact factor: 3.953
Authors: Jenna E Koschnitzky; Richard F Keep; David D Limbrick; James P McAllister; Jill A Morris; Jennifer Strahle; Yun C Yung Journal: Fluids Barriers CNS Date: 2018-03-27