OBJECTIVE: To determine whether CS delivery and receipt of antenatal steroids (ANS) in vertex-presenting singletons with a gestational age (GA) between 24 and 30 weeks is associated with improved survival and improved severe intraventricular hemorrhage (sIVH)-free survival. STUDY DESIGN: Multicenter cohort, retrospective analysis of prospectively collected data. Vertex-presenting singletons newborns with GA 24 to 30 weeks, birth weight between 500 and 1500 g, without major congenital malformations, born between 2001 and 2011 at Neocosur centers were included. RESULTS: Four thousand three hundred and eighty-six infants fulfilled inclusion criteria: 45.8% were delivered vaginally and 54.2% by cesarean section (CS). Newborns delivered vaginally received less ANS, had lower GA, Apgar scores and a lower incidence of survival and sIVH-free survival (P<0.001). Newborns with better survival were those with ANS, independent of mode of delivery. At 24 to 25 weeks GA, increased survival and sIVH-free survival were associated with ANS and CS delivery, compared with those who received ANS and delivered vaginally. CONCLUSIONS: Among vertex-presenting singletons with GA 24 to 30 weeks, better survival and IVH-free survival were associated with ANS, independent of mode of delivery. In infants at 24 to 25 weeks gestation the combination of ANS/CS was associated with improvement in both outcomes.
OBJECTIVE: To determine whether CS delivery and receipt of antenatal steroids (ANS) in vertex-presenting singletons with a gestational age (GA) between 24 and 30 weeks is associated with improved survival and improved severe intraventricular hemorrhage (sIVH)-free survival. STUDY DESIGN: Multicenter cohort, retrospective analysis of prospectively collected data. Vertex-presenting singletons newborns with GA 24 to 30 weeks, birth weight between 500 and 1500 g, without major congenital malformations, born between 2001 and 2011 at Neocosur centers were included. RESULTS: Four thousand three hundred and eighty-six infants fulfilled inclusion criteria: 45.8% were delivered vaginally and 54.2% by cesarean section (CS). Newborns delivered vaginally received less ANS, had lower GA, Apgar scores and a lower incidence of survival and sIVH-free survival (P<0.001). Newborns with better survival were those with ANS, independent of mode of delivery. At 24 to 25 weeks GA, increased survival and sIVH-free survival were associated with ANS and CS delivery, compared with those who received ANS and delivered vaginally. CONCLUSIONS: Among vertex-presenting singletons with GA 24 to 30 weeks, better survival and IVH-free survival were associated with ANS, independent of mode of delivery. In infants at 24 to 25 weeks gestation the combination of ANS/CS was associated with improvement in both outcomes.
Authors: S F Bottoms; R H Paul; J D Iams; B M Mercer; E A Thom; J M Roberts; S N Caritis; A H Moawad; J P Van Dorsten; J C Hauth; G R Thurnau; M Miodovnik; P M Meis; D McNellis Journal: Am J Obstet Gynecol Date: 1997-05 Impact factor: 8.661
Authors: Brandon W Alleman; Edward F Bell; Lei Li; John M Dagle; P Brian Smith; Namasivayam Ambalavanan; Matthew M Laughon; Barbara J Stoll; Ronald N Goldberg; Waldemar A Carlo; Jeffrey C Murray; C Michael Cotten; Seetha Shankaran; Michele C Walsh; Abbot R Laptook; Dan L Ellsbury; Ellen C Hale; Nancy S Newman; Dennis D Wallace; Abhik Das; Rosemary D Higgins Journal: Pediatrics Date: 2013-06-10 Impact factor: 7.124
Authors: Fernando Althabe; José M Belizán; Elizabeth M McClure; Jennifer Hemingway-Foday; Mabel Berrueta; Agustina Mazzoni; Alvaro Ciganda; Shivaprasad S Goudar; Bhalachandra S Kodkany; Niranjana S Mahantshetti; Sangappa M Dhaded; Geetanjali M Katageri; Mrityunjay C Metgud; Anjali M Joshi; Mrutyunjaya B Bellad; Narayan V Honnungar; Richard J Derman; Sarah Saleem; Omrana Pasha; Sumera Ali; Farid Hasnain; Robert L Goldenberg; Fabian Esamai; Paul Nyongesa; Silas Ayunga; Edward A Liechty; Ana L Garces; Lester Figueroa; K Michael Hambidge; Nancy F Krebs; Archana Patel; Anjali Bhandarkar; Manjushri Waikar; Patricia L Hibberd; Elwyn Chomba; Waldemar A Carlo; Angel Mwiche; Melody Chiwila; Albert Manasyan; Sayury Pineda; Sreelatha Meleth; Vanessa Thorsten; Kristen Stolka; Dennis D Wallace; Marion Koso-Thomas; Alan H Jobe; Pierre M Buekens Journal: Lancet Date: 2014-10-15 Impact factor: 79.321
Authors: Jenna E Koschnitzky; Richard F Keep; David D Limbrick; James P McAllister; Jill A Morris; Jennifer Strahle; Yun C Yung Journal: Fluids Barriers CNS Date: 2018-03-27