Literature DB >> 24104525

Cancer genomics identifies disrupted epigenetic genes.

Laia Simó-Riudalbas1, Manel Esteller.   

Abstract

Latest advances in genome technologies have greatly advanced the discovery of epigenetic genes altered in cancer. The initial single candidate gene approaches have been coupled with newly developed epigenomic platforms to hasten the convergence of scientific discoveries and translational applications. Here, we present an overview of the evolution of cancer epigenomics and an updated catalog of disruptions in epigenetic pathways, whose misregulation can culminate in cancer. The creation of these basic mutational catalogs in cell lines and primary tumors will provide us with enough knowledge to move diagnostics and therapy from the laboratory bench to the bedside.

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Year:  2013        PMID： 24104525     DOI： 10.1007/s00439-013-1373-5

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  121 in total

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Journal:  PLoS One       Date:  2013-01-21       Impact factor: 3.240
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  18 in total

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Review 3.  Pediatric gliomas as neurodevelopmental disorders.

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Review 4.  Directly targeting transcriptional dysregulation in cancer.

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Review 5.  Epigenome engineering in cancer: fairytale or a realistic path to the clinic?

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8.  Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia.

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Journal:  Epigenetics Chromatin       Date:  2016-11-01       Impact factor: 4.954

9.  Investigation of EZH2 pathways for novel epigenetic treatment strategies in oropharyngeal cancer.

Authors:  Sherif Idris; Cameron Lindsay; Morris Kostiuk; Colin Andrews; David W J Côté; Daniel A O'Connell; Jeffrey Harris; Hadi Seikaly; Vincent L Biron
Journal:  J Otolaryngol Head Neck Surg       Date:  2016-10-28

Review 10.  Chromatin deregulation in disease.

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