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Literature DB >> 24104390

DNA methylome: Unveiling your biological age.

Ming Li¹, Wensu Liu, Tingting Yuan, Ruijun Bai, Guang-Hui Liu, Weizhou Zhang, Jing Qu.

Abstract

Hannum and colleagues performed DNA methylation sequencing to examine the relationship between DNA methylome and aging rate. Notably, they succeeded in building a quantitative and reproducible model based on the epigenetic bio-markers to predict aging rate with high accuracy. This progress enlightens us in many aspects particularly in applying this novel set of bio-markers on studying the mechanism of aging rate using adult tissue-specific stem cells, building up a potential quantitative model to explore the mechanism for other epigenetic factors like non-coding RNA, and understanding the principle and mechanism of 3D chromatin structure in epigenetic modulation.

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Year: 2013 PMID： 24104390 PMCID： PMC4875436 DOI： 10.1007/s13238-013-3913-0

Source DB: PubMed Journal: Protein Cell ISSN： 1674-800X Impact factor: 14.870

19 in total

Review 1. Linking functional decline of telomeres, mitochondria and stem cells during ageing.

Authors: Ergün Sahin; Ronald A Depinho
Journal: Nature Date: 2010-03-25 Impact factor: 49.962

Review 2. Stems cells and the pathways to aging and cancer.

Authors: Derrick J Rossi; Catriona H M Jamieson; Irving L Weissman
Journal: Cell Date: 2008-02-22 Impact factor: 41.582

3. Age-associated inflammation inhibits epidermal stem cell function.

Authors: Jason Doles; Mekayla Storer; Luca Cozzuto; Guglielmo Roma; William M Keyes
Journal: Genes Dev Date: 2012-09-12 Impact factor: 11.361

4. Distinct DNA methylomes of newborns and centenarians.

Authors: Holger Heyn; Ning Li; Humberto J Ferreira; Sebastian Moran; David G Pisano; Antonio Gomez; Javier Diez; Jose V Sanchez-Mut; Fernando Setien; F Javier Carmona; Annibale A Puca; Sergi Sayols; Miguel A Pujana; Jordi Serra-Musach; Isabel Iglesias-Platas; Francesc Formiga; Agustin F Fernandez; Mario F Fraga; Simon C Heath; Alfonso Valencia; Ivo G Gut; Jun Wang; Manel Esteller
Journal: Proc Natl Acad Sci U S A Date: 2012-06-11 Impact factor: 11.205

5. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs.

Authors: Guang-Hui Liu; Keiichiro Suzuki; Jing Qu; Ignacio Sancho-Martinez; Fei Yi; Mo Li; Sachin Kumar; Emmanuel Nivet; Jessica Kim; Rupa Devi Soligalla; Ilir Dubova; April Goebl; Nongluk Plongthongkum; Ho-Lim Fung; Kun Zhang; Jeanne F Loring; Louise C Laurent; Juan Carlos Izpisua Belmonte
Journal: Cell Stem Cell Date: 2011-05-19 Impact factor: 24.633

6. Telomeres shorten during ageing of human fibroblasts.

Authors: C B Harley; A B Futcher; C W Greider
Journal: Nature Date: 1990-05-31 Impact factor: 49.962

7. Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring.

Authors: Davide Gentilini; Daniela Mari; Davide Castaldi; Daniel Remondini; Giulia Ogliari; Rita Ostan; Laura Bucci; Silvia M Sirchia; Silvia Tabano; Francesco Cavagnini; Daniela Monti; Claudio Franceschi; Anna Maria Di Blasio; Giovanni Vitale
Journal: Age (Dordr) Date: 2012-08-25

Review 8. Intrinsic ageing of gut epithelial stem cells.

Authors: Thomas B L Kirkwood
Journal: Mech Ageing Dev Date: 2004-12 Impact factor: 5.432

Review 9. The hallmarks of aging.

Authors: Carlos López-Otín; Maria A Blasco; Linda Partridge; Manuel Serrano; Guido Kroemer
Journal: Cell Date: 2013-06-06 Impact factor: 41.582

10. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context.

Authors: Brock C Christensen; E Andres Houseman; Carmen J Marsit; Shichun Zheng; Margaret R Wrensch; Joseph L Wiemels; Heather H Nelson; Margaret R Karagas; James F Padbury; Raphael Bueno; David J Sugarbaker; Ru-Fang Yeh; John K Wiencke; Karl T Kelsey
Journal: PLoS Genet Date: 2009-08-14 Impact factor: 5.917

1 in total

1. Olive Oil Improves While Trans Fatty Acids Further Aggravate the Hypomethylation of LINE-1 Retrotransposon DNA in an Environmental Carcinogen Model.

Authors: Laszlo Szabo; Richard Molnar; Andras Tomesz; Arpad Deutsch; Richard Darago; Timea Varjas; Zsombor Ritter; Jozsef L Szentpeteri; Kitti Andreidesz; Domokos Mathe; Imre Hegedüs; Attila Sik; Ferenc Budan; Istvan Kiss
Journal: Nutrients Date: 2022-02-21 Impact factor: 5.717

1 in total