Literature DB >> 15563938

Intrinsic ageing of gut epithelial stem cells.

Thomas B L Kirkwood1.   

Abstract

The maintenance of integrity of gut epithelium is essential for the well being of the organism throughout life. Gut epithelium is maintained through a carefully controlled balance between cell loss and renewal, which is sustained by the proliferation of the epithelial stem cells. Although these stem cells show no intrinsic limit to their proliferative capacity, recent evidence indicates that they suffer important functional impairments during the course of ageing. This paper reviews what is currently known about intrinsic ageing of gut epithelial stem cells and its functional consequences.

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Year:  2004        PMID： 15563938     DOI： 10.1016/j.mad.2004.09.004

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  22 in total

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