Literature DB >> 24102106

The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system.

Andrew Tinker1, Qadeer Aziz, Alison Thomas.   

Abstract

ATP-sensitive potassium channels (K(ATP)) are widely distributed and present in a number of tissues including muscle, pancreatic beta cells and the brain. Their activity is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP levels. Thus, they link cellular metabolism with membrane excitability. Recent studies using genetically modified mice and genomic studies in patients have implicated K(ATP) channels in a number of physiological and pathological processes. In this review, we focus on their role in cellular function and protection particularly in the cardiovascular system.
© 2013 The British Pharmacological Society.

Entities:  

Keywords:  ATP-sensitive potassium channel; cardiac myocyte; pathophysiology; physiology; smooth muscle

Mesh：

Substances：

Year:  2014        PMID： 24102106      PMCID： PMC3874693          DOI： 10.1111/bph.12407

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  153 in total

1.  ATPase activity of the sulfonylurea receptor: a catalytic function for the KATP channel complex.

Authors:  M Bienengraeber; A E Alekseev; M R Abraham; A J Carrasco; C Moreau; M Vivaudou; P P Dzeja; A Terzic
Journal:  FASEB J       Date:  2000-10       Impact factor: 5.191

2.  Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C.

Authors:  Qadeer Aziz; Alison M Thomas; Tapsi Khambra; Andrew Tinker
Journal:  J Biol Chem       Date:  2011-12-29       Impact factor: 5.157

Review 3.  The pharmacology of ATP-sensitive potassium channels.

Authors:  G Edwards; A H Weston
Journal:  Annu Rev Pharmacol Toxicol       Date:  1993       Impact factor: 13.820

4.  Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.

Authors:  N B Standen; J M Quayle; N W Davies; J E Brayden; Y Huang; M T Nelson
Journal:  Science       Date:  1989-07-14       Impact factor: 47.728

5.  Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B.

Authors:  Kevin S Thorneloe; Yoshiaki Maruyama; A Todd Malcolm; Peter E Light; Michael P Walsh; William C Cole
Journal:  J Physiol       Date:  2002-05-15       Impact factor: 5.182

Review 6.  Genetic, molecular and cellular mechanisms underlying the J wave syndromes.

Authors:  Charles Antzelevitch
Journal:  Circ J       Date:  2012-04-11       Impact factor: 2.993

7.  5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids.

Authors:  Peter J Hanley; Stefan Dröse; Ulrich Brandt; Rachel A Lareau; Abir L Banerjee; D K Srivastava; Leonard J Banaszak; Joseph J Barycki; Paul P Van Veldhoven; Jürgen Daut
Journal:  J Physiol       Date:  2004-10-28       Impact factor: 5.182

8.  Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats.

Authors:  Youqin Cheng; Joseph Fomusi Ndisang; Guanghua Tang; Kun Cao; Rui Wang
Journal:  Am J Physiol Heart Circ Physiol       Date:  2004-06-10       Impact factor: 4.733

9.  Random assembly of SUR subunits in K(ATP) channel complexes.

Authors:  Wayland W L Cheng; Ailing Tong; Thomas P Flagg; Colin G Nichols
Journal:  Channels (Austin)       Date:  2008-04-04       Impact factor: 2.581

10.  Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2.

Authors:  Scott B Hansen; Xiao Tao; Roderick MacKinnon
Journal:  Nature       Date:  2011-08-28       Impact factor: 49.962
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  39 in total

Review 1.  KATP Channels in the Cardiovascular System.

Authors:  Monique N Foster; William A Coetzee
Journal:  Physiol Rev       Date:  2016-01       Impact factor: 37.312

2.  Molecular and functional characterization of the endothelial ATP-sensitive potassium channel.

Authors:  Qadeer Aziz; Yiwen Li; Naomi Anderson; Leona Ojake; Elena Tsisanova; Andrew Tinker
Journal:  J Biol Chem       Date:  2017-09-11       Impact factor: 5.157

Review 3.  Genetic Discovery of ATP-Sensitive K+ Channels in Cardiovascular Diseases.

Authors:  Yan Huang; Dan Hu; Congxin Huang; Colin G Nichols
Journal:  Circ Arrhythm Electrophysiol       Date:  2019-05

4.  Functional modulation of sarcolemmal KATP channels by atrial natriuretic peptide-elicited intracellular signaling in adult rabbit ventricular cardiomyocytes.

Authors:  Dai-Min Zhang; Yu-Fung Lin
Journal:  Am J Physiol Cell Physiol       Date:  2020-05-20       Impact factor: 4.249

5.  The ATP-sensitive K channel is seizure protective and required for effective dietary therapy in a model of mitochondrial encephalomyopathy.

Authors:  Keri J Fogle; J Ian Hertzler; Joy H Shon; Michael J Palladino
Journal:  J Neurogenet       Date:  2016-11-21       Impact factor: 1.250

6.  Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the KATP/MAPK pathway.

Authors:  Yihan Wang; Leo M Hall; Marisa Kujawa; Hainan Li; Xiang Zhang; Megan O'Meara; Tomomi Ichinose; Jie-Mei Wang
Journal:  Am J Physiol Cell Physiol       Date:  2019-04-17       Impact factor: 4.249

Review 7.  Modulation of Cardiac Potassium Current by Neural Tone and Ischemia.

Authors:  Todd T Tomson; Rishi Arora
Journal:  Card Electrophysiol Clin       Date:  2016-03-30

8.  2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants.

Authors:  Bernard Pirotte; Xavier Florence; Eric Goffin; Philippe Lebrun
Journal:  Medchemcomm       Date:  2019-02-12       Impact factor: 3.597

9.  ATP-sensitive potassium channels in the sinoatrial node contribute to heart rate control and adaptation to hypoxia.

Authors:  Qadeer Aziz; Malcolm Finlay; David Montaigne; Leona Ojake; Yiwen Li; Naomi Anderson; Andreas Ludwig; Andrew Tinker
Journal:  J Biol Chem       Date:  2018-04-17       Impact factor: 5.157

Review 10.  Potassium channels in the sinoatrial node and their role in heart rate control.

Authors:  Qadeer Aziz; Yiwen Li; Andrew Tinker
Journal:  Channels (Austin)       Date:  2018       Impact factor: 2.581
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