Literature DB >> 31030551

Genetic Discovery of ATP-Sensitive K+ Channels in Cardiovascular Diseases.

Yan Huang1,2, Dan Hu1,2, Congxin Huang1,2, Colin G Nichols3.   

Abstract

The ATP-sensitive K+ (KATP) channels are hetero-octameric protein complexes comprising 4 pore-forming (Kir6.x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits. They are prominent in myocytes, pancreatic β cells, and neurons and link cellular metabolism with membrane excitability. Using genetically modified animals and genomic analysis in patients, recent studies have implicated certain ATP-sensitive K+ channel subtypes in physiological and pathological processes in a variety of cardiovascular diseases. In this review, we focus on the causal relationship between ATP-sensitive K+ channel activity and pathophysiology in the cardiovascular system, particularly from the perspective of genetic changes in human and animal models.

Entities:  

Keywords:  cardiovascular diseases; cardiovascular system; heart failure; neuron; sulfonylurea receptor

Mesh：

Substances：

Year:  2019        PMID： 31030551      PMCID： PMC6494091          DOI： 10.1161/CIRCEP.119.007322

Source DB:  PubMed          Journal:  Circ Arrhythm Electrophysiol        ISSN： 1941-3084


  123 in total

1.  Forkhead transcription factors coordinate expression of myocardial KATP channel subunits and energy metabolism.

Authors:  Pierre Philip-Couderc; Nadia Isidoro Tavares; Angela Roatti; René Lerch; Christophe Montessuit; Alex J Baertschi
Journal:  Circ Res       Date:  2008-01-17       Impact factor: 17.367

2.  Voltage-dependent ATP-sensitive potassium channels of skeletal muscle membrane.

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Journal:  Nature       Date:  1985 Aug 22-28       Impact factor: 49.962

3.  Hearts lacking plasma membrane KATP channels display changes in basal aerobic metabolic substrate preference and AMPK activity.

Authors:  Nermeen Youssef; Scott Campbell; Amy Barr; Manoj Gandhi; Beth Hunter; Vernon Dolinsky; Jason R B Dyck; Alexander S Clanachan; Peter E Light
Journal:  Am J Physiol Heart Circ Physiol       Date:  2017-06-30       Impact factor: 4.733

4.  ATP-regulated K+ channels in cardiac muscle.

Authors:  A Noma
Journal:  Nature       Date:  1983 Sep 8-14       Impact factor: 49.962

5.  Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.

Authors:  N B Standen; J M Quayle; N W Davies; J E Brayden; Y Huang; M T Nelson
Journal:  Science       Date:  1989-07-14       Impact factor: 47.728

Review 6.  Function and distribution of the SUR isoforms and splice variants.

Authors:  Nian-Qing Shi; Bin Ye; Jonathan C Makielski
Journal:  J Mol Cell Cardiol       Date:  2005-02-05       Impact factor: 5.000

7.  Retinal ganglion cell survival is enhanced by gabapentin-lactam in vitro: evidence for involvement of mitochondrial KATP channels.

Authors:  Amelie Pielen; Matthias Kirsch; Hans-Dieter Hofmann; Thomas J Feuerstein; Wolf A Lagrèze
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2004-02-10       Impact factor: 3.117

8.  Functional clustering of mutations in the dimer interface of the nucleotide binding folds of the sulfonylurea receptor.

Authors:  Ricard Masia; Colin G Nichols
Journal:  J Biol Chem       Date:  2008-08-20       Impact factor: 5.157

9.  Cantú syndrome with coexisting familial pituitary adenoma.

Authors:  Pedro Marques; Rupert Spencer; Patrick J Morrison; Ian M Carr; Mary N Dang; David T Bonthron; Steven Hunter; Márta Korbonits
Journal:  Endocrine       Date:  2018-01-11       Impact factor: 3.633

10.  Association between potassium channel SNPs and essential hypertension in Xinjiang Kazak Chinese patients.

Authors:  Yuan-Yuan Han; Li-Jie Wang; Liang Zhang; Wen-Wen Zhang; Ke-Tao Ma; Li Li; Jun-Qiang Si
Journal:  Exp Ther Med       Date:  2017-07-09       Impact factor: 2.447
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  8 in total

Review 1.  Kir6.1 and SUR2B in Cantú syndrome.

Authors:  Conor McClenaghan; Colin G Nichols
Journal:  Am J Physiol Cell Physiol       Date:  2022-07-25       Impact factor: 5.282

Review 2.  Subcellular trafficking and endocytic recycling of KATP channels.

Authors:  Hua-Qian Yang; Fabio A Echeverry; Assmaa ElSheikh; Ivan Gando; Sophia Anez Arredondo; Natalie Samper; Timothy Cardozo; Mario Delmar; Show-Ling Shyng; William A Coetzee
Journal:  Am J Physiol Cell Physiol       Date:  2022-05-04       Impact factor: 5.282

3.  Transcriptome-Guided Identification of Drugs for Repurposing to Treat Age-Related Hearing Loss.

Authors:  Nick M A Schubert; Marcel van Tuinen; Sonja J Pyott
Journal:  Biomolecules       Date:  2022-03-25

4.  The expression of ATP-sensitive potassium channels in human umbilical arteries with severe pre-eclampsia.

Authors:  Benlan Yin; Yujiao Zhang; Xiaohong Wei; Chunrong Pang; Ting Hou; Chao Yang; Yuzhi Ning; Xiaodong Fu
Journal:  Sci Rep       Date:  2021-04-12       Impact factor: 4.379

5.  Vascular KATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides.

Authors:  Min Woo Sung; Zhongying Yang; Camden M Driggers; Bruce L Patton; Barmak Mostofian; John D Russo; Daniel M Zuckerman; Show-Ling Shyng
Journal:  Proc Natl Acad Sci U S A       Date:  2021-11-02       Impact factor: 11.205

Review 6.  Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases.

Authors:  Zhicheng Wang; Weikang Bian; Yufeng Yan; Dai-Min Zhang
Journal:  Front Pharmacol       Date:  2022-06-28       Impact factor: 5.988

Review 7.  Clinical Importance of the Human Umbilical Artery Potassium Channels.

Authors:  Margarida Lorigo; Nelson Oliveira; Elisa Cairrao
Journal:  Cells       Date:  2020-08-25       Impact factor: 6.600

Review 8.  'Resistance is futile?' - paradoxical inhibitory effects of KATP channel closure in glucagon-secreting α-cells.

Authors:  Quan Zhang; Haiqiang Dou; Patrik Rorsman
Journal:  J Physiol       Date:  2020-08-07       Impact factor: 6.228
  8 in total

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