| Literature DB >> 24095199 |
Jenna M Frame1, Kathleen E McGrath, James Palis.
Abstract
Erythro-myeloid progenitors (EMP) serve as a major source of hematopoiesis in the developing conceptus prior to the formation of a permanent blood system. In this review, we summarize the current knowledge regarding the emergence, fate, and potential of this hematopoietic stem cell (HSC)-independent wave of hematopoietic progenitors, focusing on the murine embryo as a model system. A better understanding of the temporal and spatial control of hematopoietic emergence in the embryo will ultimately improve our ability to derive hematopoietic stem and progenitor cells from embryonic stem cells and induced pluripotent stem cells to serve therapeutic purposes.Entities:
Keywords: AGM; BFU-E; E; EMP; ESC; Embryogenesis; Erythro-myeloid progenitors; HSC; Hematopoiesis; Hpf; Yolk sac; aorta–gonad-mesonephros; burst-forming units erythroid; embryonic day; embryonic stem cell; erythro-myeloid progenitors; hematopoietic stem cell; hours post fertilization; iPSC; induced pluripotent stem cell
Mesh:
Year: 2013 PMID: 24095199 PMCID: PMC3852668 DOI: 10.1016/j.bcmd.2013.09.006
Source DB: PubMed Journal: Blood Cells Mol Dis ISSN: 1079-9796 Impact factor: 3.039