| Literature DB >> 25902481 |
Guillaume Hoeffel1, Jinmiao Chen1, Yonit Lavin2, Donovan Low1, Francisca F Almeida1, Peter See1, Anna E Beaudin3, Josephine Lum1, Ivy Low1, E Camilla Forsberg3, Michael Poidinger1, Francesca Zolezzi1, Anis Larbi1, Lai Guan Ng1, Jerry K Y Chan4, Melanie Greter5, Burkhard Becher5, Igor M Samokhvalov6, Miriam Merad2, Florent Ginhoux7.
Abstract
Although classified as hematopoietic cells, tissue-resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth to generate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis. We show that YS MFs are the main precursors of microglia, while most other MFs derive from fetal monocytes (MOs). Both YS MFs and fetal MOs arise from erythro-myeloid progenitors (EMPs) generated in the YS. In the YS, EMPs gave rise to MFs without monocytic intermediates, while EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave rise to fetal MOs that then seeded embryonic tissues and differentiated into MFs. Thus, adult tissue-resident MFs established from hematopoietic stem cell-independent embryonic precursors arise from two distinct developmental programs.Entities:
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Year: 2015 PMID： 25902481 PMCID： PMC4545768 DOI： 10.1016/j.immuni.2015.03.011
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745