PURPOSE: To determine developmental outcomes and associated factors in patients with congenital diaphragmatic hernia (CDH) at 2 years of age. METHODS: This is a multicenter prospective study of a CDH birth cohort. Clinical and socioeconomic data were collected. Bayley Scales of Infant Development (BSID-III) and Vineland Adaptive Behavior Scales (VABS-II) were performed at 2 years of age. RESULTS: BSID-III and VABS-II assessments were completed on 48 and 49 children, respectively. The BSID-III mean cognitive, language, and motor scores were significantly below the norm mean with average scores of 93 ± 15, 95 ± 16, and 95 ± 11. Ten percent (5/47) scored more than 2 standard deviations below the norm on one or more domains. VABS-II scores were similar to BSID-III scores with mean communication, daily living skills, social, motor, adaptive behavior scores of 97 ± 14, 94 ± 16, 93 ± 13, 97 ± 10, and 94 ± 14. For the BSID-III, supplemental oxygen at 28 days, a prenatal diagnosis, need for extracorporeal membrane oxygenation (ECMO) and exclusive tube feeds at time of discharge were associated with lower scores. At 2 years of age, history of hospital readmission and need for tube feeds were associated with lower scores. Lower socioeconomic status correlated with lower developmental scores when adjusted for significant health factors. CONCLUSION: CDH patients on average have lower developmental scores at 2 years of age compared to the norm. A need for ECMO, oxygen at 28 days of life, ongoing health issues and lower socioeconomic status are factors associated with developmental delays.
PURPOSE: To determine developmental outcomes and associated factors in patients with congenital diaphragmatic hernia (CDH) at 2 years of age. METHODS: This is a multicenter prospective study of a CDH birth cohort. Clinical and socioeconomic data were collected. Bayley Scales of Infant Development (BSID-III) and Vineland Adaptive Behavior Scales (VABS-II) were performed at 2 years of age. RESULTS:BSID-III and VABS-II assessments were completed on 48 and 49 children, respectively. The BSID-III mean cognitive, language, and motor scores were significantly below the norm mean with average scores of 93 ± 15, 95 ± 16, and 95 ± 11. Ten percent (5/47) scored more than 2 standard deviations below the norm on one or more domains. VABS-II scores were similar to BSID-III scores with mean communication, daily living skills, social, motor, adaptive behavior scores of 97 ± 14, 94 ± 16, 93 ± 13, 97 ± 10, and 94 ± 14. For the BSID-III, supplemental oxygen at 28 days, a prenatal diagnosis, need for extracorporeal membrane oxygenation (ECMO) and exclusive tube feeds at time of discharge were associated with lower scores. At 2 years of age, history of hospital readmission and need for tube feeds were associated with lower scores. Lower socioeconomic status correlated with lower developmental scores when adjusted for significant health factors. CONCLUSION: CDH patients on average have lower developmental scores at 2 years of age compared to the norm. A need for ECMO, oxygen at 28 days of life, ongoing health issues and lower socioeconomic status are factors associated with developmental delays.
Authors: C S Muratore; V Kharasch; D P Lund; C Sheils; S Friedman; C Brown; S Utter; T Jaksic; J M Wilson Journal: J Pediatr Surg Date: 2001-01 Impact factor: 2.545
Authors: Lan Yu; Julia Wynn; Lijiang Ma; Saurav Guha; George B Mychaliska; Timothy M Crombleholme; Kenneth S Azarow; Foong Yen Lim; Dai H Chung; Douglas Potoka; Brad W Warner; Brian Bucher; Charles A LeDuc; Katherine Costa; Charles Stolar; Gudrun Aspelund; Marc S Arkovitz; Wendy K Chung Journal: J Med Genet Date: 2012-10 Impact factor: 6.318
Authors: Charlene M T Robertson; Juzer M Tyebkhan; Marian E Hagler; Po-Yin Cheung; Abraham Peliowski; Philip C Etches Journal: Otol Neurotol Date: 2002-05 Impact factor: 2.311
Authors: Lu Qiao; Le Xu; Lan Yu; Julia Wynn; Rebecca Hernan; Xueya Zhou; Christiana Farkouh-Karoleski; Usha S Krishnan; Julie Khlevner; Aliva De; Annette Zygmunt; Timothy Crombleholme; Foong-Yen Lim; Howard Needelman; Robert A Cusick; George B Mychaliska; Brad W Warner; Amy J Wagner; Melissa E Danko; Dai Chung; Douglas Potoka; Przemyslaw Kosiński; David J McCulley; Mahmoud Elfiky; Kenneth Azarow; Elizabeth Fialkowski; David Schindel; Samuel Z Soffer; Jane B Lyon; Jill M Zalieckas; Badri N Vardarajan; Gudrun Aspelund; Vincent P Duron; Frances A High; Xin Sun; Patricia K Donahoe; Yufeng Shen; Wendy K Chung Journal: Am J Hum Genet Date: 2021-09-20 Impact factor: 11.025
Authors: Enrico Danzer; Casey Hoffman; Jo Ann D'Agostino; Judith S Miller; Lindsay N Waqar; Marsha Gerdes; Judy C Bernbaum; Hannah Rosenthal; Natalie E Rintoul; Lisa M Herkert; William H Peranteau; Alan W Flake; N Scott Adzick; Holly L Hedrick Journal: J Autism Dev Disord Date: 2018-06
Authors: K A Kosiv; A Moon-Grady; W Hogan; R Keller; R Rapoport; E Rogers; V A Feldstein; H Lee; S Peyvandi Journal: Ultrasound Obstet Gynecol Date: 2021-03 Impact factor: 7.299
Authors: Sarah L Bauer Huang; Ahmed S Said; Christopher D Smyser; John C Lin; Kristin P Guilliams; Réjean M Guerriero Journal: J Child Neurol Date: 2020-10-28 Impact factor: 1.987
Authors: Gabrielle Kardon; Kate G Ackerman; David J McCulley; Yufeng Shen; Julia Wynn; Linshan Shang; Eric Bogenschutz; Xin Sun; Wendy K Chung Journal: Dis Model Mech Date: 2017-08-01 Impact factor: 5.758