| Literature DB >> 29383650 |
Enrico Danzer1, Casey Hoffman2, Jo Ann D'Agostino2, Judith S Miller3, Lindsay N Waqar2, Marsha Gerdes2, Judy C Bernbaum2, Hannah Rosenthal2, Natalie E Rintoul2, Lisa M Herkert2, William H Peranteau2, Alan W Flake2, N Scott Adzick2, Holly L Hedrick2.
Abstract
To determine the rate and predictors of autism spectrum disorder (ASD) in congenital diaphragmatic hernia (CDH). Between 06/2004 and 09/2015 a total of 110 CDH survivors underwent neurodevelopmental (ND) testing and screening for ASD, followed by a full autism diagnostic evaluation if indicated at our institution. We found a 9 time higher rate of ASD in CDH children compared to the general population (P = 0.0002). Multiple patient-related and clinical variables risk factors of ASD were identified by univariate analysis. However, only short-term and long-term neurodevelopmental delays were strongly associated with ASD in CDH by multivariate comparisons. There is a striking prevalence of ASD in CDH survivors and our findings suggest that all CDH children should be regularly screened for ASD.Entities:
Keywords: Autism diagnostic observation schedule; Autism spectrum disorder; Congenital diaphragmatic hernia; Neurodevelopmental delay; Pulmonary hypertension; Pulmonary hypoplasia
Mesh：
Year: 2018 PMID： 29383650 DOI： 10.1007/s10803-018-3472-6
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257