CONTEXT: Human brown adipose tissue (BAT) is activated with cold exposure, but it is unknown whether overfeeding activates BAT. OBJECTIVE: We determined BAT activation with cold, fasting, and overfeeding and the relationship of BAT activation with future weight change. DESIGN, SETTING, PARTICIPANTS, AND INTERVENTIONS: Sixteen healthy adults were evaluated during energy balance, fasting, and 24 hours of 200% overfeeding. All subjects had a fluorodeoxyglucose-positron emission tomography (PET) scan after exposure to 16°C to determine cold-induced BAT activity (CIBA). The first six subjects had a second PET scan after 36 hours of fasting to establish the lack of BAT activation at 22°C. The other subjects' second PET scan occurred after 24 hours of overfeeding at 22°C but only if they demonstrated CIBA. Twelve subjects returned at 6 months for reassessment of body composition. MAIN OUTCOME MEASURES: BAT was defined in cool scans as voxels with a standardized uptake value (SUV) of 2.0 or greater and Hounsfield units between -250 and -10. Body composition was assessed by dual-energy x-ray absorptiometry. RESULTS: Although 75% of the subjects demonstrated visible CIBA, none had visual BAT activity after overfeeding. CIBA was greater than that observed in the same defined BAT voxels after fasting (n = 6; 2.9 ± 0.5 vs 1.2 ± 0.2; Δ = -1.7; 95% confidence interval -2.4, -1.0 SUV; P < .01). In the second cohort, CIBA was also higher than observed BAT voxel activity after 24 hours overfeeding (n = 8; 3.5 ± 0.7 vs 0.9 ± 0.2; Δ = -2.6; 95% confidence interval -3.2, -1.9 SUV; P < .01). Baseline CIBA negatively correlated with changes in fat mass after 6 months (r = -0.72, P = .009). CONCLUSIONS: BAT may be important in weight regulation unrelated to the response to overeating.
CONTEXT: Human brown adipose tissue (BAT) is activated with cold exposure, but it is unknown whether overfeeding activates BAT. OBJECTIVE: We determined BAT activation with cold, fasting, and overfeeding and the relationship of BAT activation with future weight change. DESIGN, SETTING, PARTICIPANTS, AND INTERVENTIONS: Sixteen healthy adults were evaluated during energy balance, fasting, and 24 hours of 200% overfeeding. All subjects had a fluorodeoxyglucose-positron emission tomography (PET) scan after exposure to 16°C to determine cold-induced BAT activity (CIBA). The first six subjects had a second PET scan after 36 hours of fasting to establish the lack of BAT activation at 22°C. The other subjects' second PET scan occurred after 24 hours of overfeeding at 22°C but only if they demonstrated CIBA. Twelve subjects returned at 6 months for reassessment of body composition. MAIN OUTCOME MEASURES: BAT was defined in cool scans as voxels with a standardized uptake value (SUV) of 2.0 or greater and Hounsfield units between -250 and -10. Body composition was assessed by dual-energy x-ray absorptiometry. RESULTS: Although 75% of the subjects demonstrated visible CIBA, none had visual BAT activity after overfeeding. CIBA was greater than that observed in the same defined BAT voxels after fasting (n = 6; 2.9 ± 0.5 vs 1.2 ± 0.2; Δ = -1.7; 95% confidence interval -2.4, -1.0 SUV; P < .01). In the second cohort, CIBA was also higher than observed BAT voxel activity after 24 hours overfeeding (n = 8; 3.5 ± 0.7 vs 0.9 ± 0.2; Δ = -2.6; 95% confidence interval -3.2, -1.9 SUV; P < .01). Baseline CIBA negatively correlated with changes in fat mass after 6 months (r = -0.72, P = .009). CONCLUSIONS: BAT may be important in weight regulation unrelated to the response to overeating.
Authors: Aaron M Cypess; Sanaz Lehman; Gethin Williams; Ilan Tal; Dean Rodman; Allison B Goldfine; Frank C Kuo; Edwin L Palmer; Yu-Hua Tseng; Alessandro Doria; Gerald M Kolodny; C Ronald Kahn Journal: N Engl J Med Date: 2009-04-09 Impact factor: 91.245
Authors: Kirsi A Virtanen; Martin E Lidell; Janne Orava; Mikael Heglind; Rickard Westergren; Tarja Niemi; Markku Taittonen; Jukka Laine; Nina-Johanna Savisto; Sven Enerbäck; Pirjo Nuutila Journal: N Engl J Med Date: 2009-04-09 Impact factor: 91.245
Authors: Marie S Thearle; Nicola Pannacciulli; Susan Bonfiglio; Karel Pacak; Jonathan Krakoff Journal: J Clin Endocrinol Metab Date: 2013-05-10 Impact factor: 5.958
Authors: Brittany Begaye; Paolo Piaggi; Marie S Thearle; Kaitlyn Haskie; Mary Walter; Mathias Schlögl; Susan Bonfiglio; Jonathan Krakoff; Karyne L Vinales Journal: J Clin Endocrinol Metab Date: 2018-07-01 Impact factor: 5.958
Authors: Courtney M Peterson; Mahdi Orooji; Deanna N Johnson; Mort Naraghi-Pour; Eric Ravussin Journal: Obesity (Silver Spring) Date: 2017-01-24 Impact factor: 5.002
Authors: François Haman; Sara C S Souza; John W Castellani; Maria-P Dupuis; Karl E Friedl; Wendy Sullivan-Kwantes; Boris R M Kingma Journal: Temperature (Austin) Date: 2022-05-29
Authors: Tim Hollstein; Karyne Vinales; Kong Y Chen; Aaron M Cypess; Alessio Basolo; Mathias Schlögl; Jonathan Krakoff; Paolo Piaggi Journal: Metabolism Date: 2021-01-18 Impact factor: 8.694
Authors: Courtney M Peterson; Virgile Lecoultre; Elizabeth A Frost; Jonathan Simmons; Leanne M Redman; Eric Ravussin Journal: Obesity (Silver Spring) Date: 2015-11-23 Impact factor: 5.002