Literature DB >> 18456553

Revisiting an old acquaintance: CD26 and its molecular mechanisms in T cell function.

Kei Ohnuma1, Nam H Dang, Chikao Morimoto.   

Abstract

The role of CD26 in human T cell biology is puzzling. Despite being extensively characterized, it has been called 'a moonlighting protein' since it has multifunctional effects, but a definitive native ligand has not been identified. We summarize the current knowledge on the molecular mechanisms of CD26-mediated T cell costimulation and immune regulation. Work identifying a ligand for CD26 and elucidating the proximal signaling events associated with CD26-mediated T cell costimulation is also described. Finally, we discuss the involvement of CD26 in various pathophysiologic states as well as its suitability as a potential therapeutic target in selected immune diseases.

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Year:  2008        PMID： 18456553     DOI： 10.1016/j.it.2008.02.010

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  89 in total

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6.  Altered proportions of naïve, central memory and terminally differentiated central memory subsets among CD4+ and CD8 + T cells expressing CD26 in patients with type 1 diabetes.

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8.  Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells.

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Journal:  J Immunol       Date:  2015-03-13       Impact factor: 5.422

Review 9.  Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence.

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10.  CD26/dipeptidyl peptidase 4-deficiency alters thymic emigration patterns and leukcocyte subsets in F344-rats age-dependently.

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Journal:  Clin Exp Immunol       Date:  2008-12-01       Impact factor: 4.330
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