PURPOSE: Due to their properties and characteristics human mesenchymal stem cells (MSCs) appear to have great therapeutic potential. Many different populations of MSCs have been described and to understand whether they have equivalent biological properties is a critical issue for their therapeutic application. METHODS: We proposed to analyze the in vitro growth kinetics of MSCs derived from different body sites (iliac crest bone marrow, vertebrae bone marrow, colon mucosa, dental pulp). RESULTS: Mesenchymal stem cells derived from vertebrae can be maintained in culture for a greater number of steps and they also generate mature cells of all mesenchymal lineages with greater efficiency, when induced into osteogenic, adipogenic and chondrogenic differentiation. CONCLUSIONS: The ability of vertebrae-derived MSCs in terms of expansion and differentiation is very interesting at the light of a clinical application for bone fusion in spine surgery.
PURPOSE: Due to their properties and characteristics human mesenchymal stem cells (MSCs) appear to have great therapeutic potential. Many different populations of MSCs have been described and to understand whether they have equivalent biological properties is a critical issue for their therapeutic application. METHODS: We proposed to analyze the in vitro growth kinetics of MSCs derived from different body sites (iliac crest bone marrow, vertebrae bone marrow, colon mucosa, dental pulp). RESULTS: Mesenchymal stem cells derived from vertebrae can be maintained in culture for a greater number of steps and they also generate mature cells of all mesenchymal lineages with greater efficiency, when induced into osteogenic, adipogenic and chondrogenic differentiation. CONCLUSIONS: The ability of vertebrae-derived MSCs in terms of expansion and differentiation is very interesting at the light of a clinical application for bone fusion in spine surgery.
Authors: Dmitriy Sheyn; Ilan Kallai; Wafa Tawackoli; Doron Cohn Yakubovich; Anthony Oh; Susan Su; Xiaoyu Da; Amir Lavi; Nadav Kimelman-Bleich; Yoram Zilberman; Ning Li; Hyun Bae; Zulma Gazit; Gadi Pelled; Dan Gazit Journal: Mol Pharm Date: 2011-09-13 Impact factor: 4.939
Authors: Andre F Steinert; Lars Rackwitz; Fabian Gilbert; Ulrich Nöth; Rocky S Tuan Journal: Stem Cells Transl Med Date: 2012-02-22 Impact factor: 6.940
Authors: M F Pittenger; A M Mackay; S C Beck; R K Jaiswal; R Douglas; J D Mosca; M A Moorman; D W Simonetti; S Craig; D R Marshak Journal: Science Date: 1999-04-02 Impact factor: 47.728
Authors: M Manfrini; C Di Bona; A Canella; E Lucarelli; A Pellati; A D'Agostino; G Barbanti-Bròdano; M Tognon Journal: J Cell Physiol Date: 2013-06 Impact factor: 6.384
Authors: F Salamanna; M Sartori; G Barbanti Brodano; C Griffoni; L Martini; S Boriani; M Fini Journal: Stem Cells Int Date: 2017-02-13 Impact factor: 5.443
Authors: Evangelos M Fragkakis; Jehan Jomaa El-Jawhari; Robert A Dunsmuir; Peter A Millner; Abhay S Rao; Karen T Henshaw; Ippokratis Pountos; Elena Jones; Peter V Giannoudis Journal: PLoS One Date: 2018-05-24 Impact factor: 3.240
Authors: F Salamanna; D Contartese; G Giavaresi; L Sicuro; G Barbanti Brodano; A Gasbarrini; M Fini Journal: Sci Rep Date: 2020-03-05 Impact factor: 4.379
Authors: El-Mustapha Haddouti; Thomas M Randau; Cäcilia Hilgers; Werner Masson; Robert Pflugmacher; Christof Burger; Sascha Gravius; Frank A Schildberg Journal: Int J Mol Sci Date: 2020-11-05 Impact factor: 5.923