Literature DB >> 24054182

Screening for a diamond in the rough.

Xiaoqian Wu1, Julian G Hurdle.   

Abstract

Contrary to the standard of eliminating antimicrobial hits that collapse bacterial proton motive force (PMF), in this issue of Chemistry and Biology, Farha and colleagues describe the value of screens to identify molecules that dissipate PMF, yet are nonbacteriolytic and selectively toxic.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 24054182      PMCID： PMC3843516          DOI： 10.1016/j.chembiol.2013.09.002

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  9 in total

1.  Daptomycin-mediated reorganization of membrane architecture causes mislocalization of essential cell division proteins.

Authors:  Joe Pogliano; Nicolas Pogliano; Jared A Silverman
Journal:  J Bacteriol       Date:  2012-06-01       Impact factor: 3.490

Review 2.  The challenge of new drug discovery for tuberculosis.

Authors:  Anil Koul; Eric Arnoult; Nacer Lounis; Jerome Guillemont; Koen Andries
Journal:  Nature       Date:  2011-01-27       Impact factor: 49.962

Review 3.  Preclinical evaluation of novel antibacterial agents by microbiological and molecular techniques.

Authors:  Alex J O'Neill; Ian Chopra
Journal:  Expert Opin Investig Drugs       Date:  2004-08       Impact factor: 6.206

Review 4.  Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Authors:  David J Payne; Michael N Gwynn; David J Holmes; David L Pompliano
Journal:  Nat Rev Drug Discov       Date:  2006-12-08       Impact factor: 84.694

5.  The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze-etch electron microscopy.

Authors:  A J Verkleij; R F Zwaal; B Roelofsen; P Comfurius; D Kastelijn; L L van Deenen
Journal:  Biochim Biophys Acta       Date:  1973-10-11

Review 6.  Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections.

Authors:  Julian G Hurdle; Alex J O'Neill; Ian Chopra; Richard E Lee
Journal:  Nat Rev Microbiol       Date:  2011-01       Impact factor: 60.633

Review 7.  Molecular aspects of bacterial pH sensing and homeostasis.

Authors:  Terry A Krulwich; George Sachs; Etana Padan
Journal:  Nat Rev Microbiol       Date:  2011-04-05       Impact factor: 60.633

8.  A rapid microtiter plate assay for measuring the effect of compounds on Staphylococcus aureus membrane potential.

Authors:  Daniel R Gentry; Imogen Wilding; John M Johnson; Dongzhao Chen; Katja Remlinger; Cindy Richards; Susan Neill; Magdalena Zalacain; Stephen F Rittenhouse; Michael N Gwynn
Journal:  J Microbiol Methods       Date:  2010-08-27       Impact factor: 2.363

9.  Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus.

Authors:  Maya A Farha; Chris P Verschoor; Dawn Bowdish; Eric D Brown
Journal:  Chem Biol       Date:  2013-08-22
  9 in total
  1 in total

1.  Chemical modulation of the biological activity of reutericyclin: a membrane-active antibiotic from Lactobacillus reuteri.

Authors:  Philip T Cherian; Xiaoqian Wu; Marcus M Maddox; Aman P Singh; Richard E Lee; Julian G Hurdle
Journal:  Sci Rep       Date:  2014-04-17       Impact factor: 4.379
  1 in total

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