| Literature DB >> 20801170 |
Daniel R Gentry1, Imogen Wilding, John M Johnson, Dongzhao Chen, Katja Remlinger, Cindy Richards, Susan Neill, Magdalena Zalacain, Stephen F Rittenhouse, Michael N Gwynn.
Abstract
We developed a homogenous microtiter based assay using the cationic dye 3, 3'-Diethyloxacarbocyanine iodide, DiOC2(3), to measure the effect of compounds on membrane potential in Staphylococcus aureus. In a screen of 372 compounds from a synthetic compound collection with anti-Escherichia coli activity due to unknown modes of action at least 17% demonstrated potent membrane activity, enabling rapid discrimination of nuisance compounds.Entities:
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Year: 2010 PMID： 20801170 DOI： 10.1016/j.mimet.2010.08.012
Source DB: PubMed Journal: J Microbiol Methods ISSN： 0167-7012 Impact factor: 2.363