| Literature DB >> 24046315 |
Daniel C Berry1, Drew Stenesen, Daniel Zeve, Jonathan M Graff.
Abstract
Adipose tissue is formed at stereotypic times and locations in a diverse array of organisms. Once formed, the tissue is dynamic, responding to homeostatic and external cues and capable of a 15-fold expansion. The formation and maintenance of adipose tissue is essential to many biological processes and when perturbed leads to significant diseases. Despite this basic and clinical significance, understanding of the developmental biology of adipose tissue has languished. In this Review, we highlight recent efforts to unveil adipose developmental cues, adipose stem cell biology and the regulators of adipose tissue homeostasis and dynamism.Keywords: Adipocyte; Adipose; Development; Niche; Stem cells; Vascular niche
Mesh:
Year: 2013 PMID: 24046315 PMCID: PMC3775412 DOI: 10.1242/dev.080549
Source DB: PubMed Journal: Development ISSN: 0950-1991 Impact factor: 6.868