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Literature DB >> 28425843

The dual role of BMP4 in adipogenesis and metabolism.

Abstract

BMP4 has a well-established role in triggering commitment of mesenchymal stem cells into the osteogenic and adipogenic linage. We recently described an additional dual function in adipogenesis: after promoting the formation of both white and brown pre-adipocytes, Bmp4 drives terminal differentiation into mature white rather than brown fat cells. Besides this, Bmp4 seems to have a dual role in metabolism either promoting or repressing oxidative metabolism in a cell context dependent manner.

Entities: Gene

Keywords: Adipogenesis; Bmp4; MSC; comittment; terminal differentiation

Mesh：

Substances：

Year: 2017 PMID： 28425843 PMCID： PMC5477726 DOI： 10.1080/21623945.2017.1287637

Source DB: PubMed Journal: Adipocyte ISSN： 2162-3945 Impact factor: 4.534

45 in total

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Authors: Hilary L Ashe
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2. White fat progenitor cells reside in the adipose vasculature.

Authors: Wei Tang; Daniel Zeve; Jae Myoung Suh; Darko Bosnakovski; Michael Kyba; Robert E Hammer; Michelle D Tallquist; Jonathan M Graff
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Review 3. Bone morphogenic proteins signaling in adipogenesis and energy homeostasis.

Authors: Salvatore Modica; Christian Wolfrum
Journal: Biochim Biophys Acta Date: 2013-01-23

4. UCP1 mRNA does not produce heat.

Authors: Jan Nedergaard; Barbara Cannon
Journal: Biochim Biophys Acta Date: 2013-01-22

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Authors: Qi Qun Tang; M Daniel Lane
Journal: Annu Rev Biochem Date: 2012-03-29 Impact factor: 23.643

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Authors: Birgit Gustafson; Ann Hammarstedt; Shahram Hedjazifar; Jenny M Hoffmann; Per-Arne Svensson; Joseph Grimsby; Cristina Rondinone; Ulf Smith
Journal: Diabetes Date: 2015-01-20 Impact factor: 9.461

7. BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis.

Authors: Shu-Wen Qian; Yan Tang; Xi Li; Yuan Liu; You-You Zhang; Hai-Yan Huang; Rui-Dan Xue; Hao-Yong Yu; Liang Guo; Hui-Di Gao; Yan Liu; Xia Sun; Yi-Ming Li; Wei-Ping Jia; Qi-Qun Tang
Journal: Proc Natl Acad Sci U S A Date: 2013-02-06 Impact factor: 11.205

8. Bmp4 expressed in preadipocytes is required for the onset of adipocyte differentiation.

Authors: Masashi Suenaga; Norio Kurosawa; Hiroki Asano; Yohei Kanamori; Takenao Umemoto; Hirofumi Yoshida; Masaru Murakami; Hiroyuki Kawachi; Tohru Matsui; Masayuki Funaba
Journal: Cytokine Date: 2013-08-02 Impact factor: 3.861

9. Characterization of Cre recombinase models for the study of adipose tissue.

Authors: Elise Jeffery; Ryan Berry; Christopher D Church; Songtao Yu; Brett A Shook; Valerie Horsley; Evan D Rosen; Matthew S Rodeheffer
Journal: Adipocyte Date: 2014-06-27 Impact factor: 4.534

10. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.

Authors: Andrew J Whittle; Meizi Jiang; Vivian Peirce; Joana Relat; Sam Virtue; Hiroyuki Ebinuma; Isamu Fukamachi; Takashi Yamaguchi; Mao Takahashi; Takeyoshi Murano; Ichiro Tatsuno; Masahiro Takeuchi; Chiaki Nakaseko; Wenlong Jin; Zhehu Jin; Mark Campbell; Wolfgang J Schneider; Antonio Vidal-Puig; Hideaki Bujo
Journal: Nat Commun Date: 2015-11-20 Impact factor: 14.919

12 in total

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Review 2. Pathophysiology and Emerging Molecular Therapeutic Targets in Heterotopic Ossification.

Authors: Favour Felix-Ilemhenbhio; George A E Pickering; Endre Kiss-Toth; Jeremy Mark Wilkinson
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Review 3. The Role of Bone Morphogenetic Protein 4 in Ovarian Function and Diseases.

Authors: Dongyong Yang; Xiao Yang; Fangfang Dai; Yanqing Wang; Yi Yang; Min Hu; Yanxiang Cheng
Journal: Reprod Sci Date: 2021-05-08 Impact factor: 3.060

Review 4. Identification and characterization of adipose surface epitopes.

Authors: Yasuhiro Onogi; Ahmed Elagamy Mohamed Mahmoud Khalil; Siegfried Ussar
Journal: Biochem J Date: 2020-07-17 Impact factor: 3.857

5. BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells.

Authors: Duc-Hiep Bach; Thi-Thu-Trang Luu; Donghwa Kim; Yong Jin An; Sunghyouk Park; Hyen Joo Park; Sang Kook Lee
Journal: Mol Ther Nucleic Acids Date: 2018-08-04 Impact factor: 8.886

Review 6. On the role of macrophages in the control of adipocyte energy metabolism.

Authors: Michaela Keuper
Journal: Endocr Connect Date: 2019-06 Impact factor: 3.335

7. Increased Gene Expression of RUNX2 and SOX9 in Mesenchymal Circulating Progenitors Is Associated with Autophagy during Physical Activity.

Authors: L Dalle Carbonare; M Mottes; S Cheri; M Deiana; F Zamboni; D Gabbiani; F Schena; G L Salvagno; G Lippi; M T Valenti
Journal: Oxid Med Cell Longev Date: 2019-10-15 Impact factor: 6.543

8. BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1.

Authors: Victoria Prieto-Echagüe; Sukanya Lodh; Laura Colman; Natalia Bobba; Leonardo Santos; Nicholas Katsanis; Carlos Escande; Norann A Zaghloul; Jose L Badano
Journal: Sci Rep Date: 2017-08-29 Impact factor: 4.379

9. A Lox/CHOP-10 crosstalk governs osteogenic and adipogenic cell fate by MSCs.

Authors: Wen-Yan Jiang; Chun Xing; Hong-Wei Wang; Wei Wang; Su-Zhen Chen; Liu-Fang Ning; Xu Xu; Qi-Qun Tang; Hai-Yan Huang
Journal: J Cell Mol Med Date: 2018-07-25 Impact factor: 5.310

Review 10. Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism.

Authors: Camilla Scheele; Christian Wolfrum
Journal: Endocr Rev Date: 2020-01-01 Impact factor: 19.871