Literature DB >> 24045579

Holographic display system for restoration of sight to the blind.

G A Goetz1, Y Mandel, R Manivanh, D V Palanker, T Čižmár.   

Abstract

OBJECTIVE: We present a holographic near-the-eye display system enabling optical approaches for sight restoration to the blind, such as photovoltaic retinal prosthesis, optogenetic and other photoactivation techniques. We compare it with conventional liquid crystal displays (LCD) or digital light processing (DLP)-based displays in terms of image quality, field of view, optical efficiency and safety. APPROACH: We detail the optical configuration of the holographic display system and its characterization using a phase-only spatial light modulator. MAIN
RESULTS: We describe approaches to controlling the zero diffraction order and speckle related issues in holographic display systems and assess the image quality of such systems. We show that holographic techniques offer significant advantages in terms of peak irradiance and power efficiency, and enable designs that are inherently safer than LCD or DLP-based systems. We demonstrate the performance of our holographic display system in the assessment of cortical response to alternating gratings projected onto the retinas of rats. SIGNIFICANCE: We address the issues associated with the design of high brightness, near-the-eye display systems and propose solutions to the efficiency and safety challenges with an optical design which could be miniaturized and mounted onto goggles.

Entities:  

Mesh:

Year:  2013        PMID: 24045579      PMCID: PMC3893035          DOI: 10.1088/1741-2560/10/5/056021

Source DB:  PubMed          Journal:  J Neural Eng        ISSN: 1741-2552            Impact factor:   5.379


  38 in total

1.  Electrical multisite stimulation of the isolated chicken retina.

Authors:  A Stett; W Barth; S Weiss; H Haemmerle; E Zrenner
Journal:  Vision Res       Date:  2000       Impact factor: 1.886

2.  Behavioral assessment of visual acuity in mice and rats.

Authors:  G T Prusky; P W West; R M Douglas
Journal:  Vision Res       Date:  2000       Impact factor: 1.886

Review 3.  [Subretinal microphotodiode array as replacement for degenerated photoreceptors?].

Authors:  E Zrenner; F Gekeler; V P Gabel; H G Graf; M Graf; E Guenther; H Haemmerle; B Hoefflinger; K Kobuch; K Kohler; W Nisch; H Sachs; B Schlosshauer; M Schubert; H Schwahn; M Stelzle; A Stett; B Troeger; S Weiss
Journal:  Ophthalmologe       Date:  2001-04       Impact factor: 1.059

4.  Visual and electrical evoked response recorded from subdural electrodes implanted above the visual cortex in normal dogs under two methods of anesthesia.

Authors:  E Margalit; J D Weiland; R E Clatterbuck; G Y Fujii; M Maia; M Tameesh; G Torres; S A D'Anna; S Desai; D V Piyathaisere; A Olivi; E de Juan; Mark S Humayun
Journal:  J Neurosci Methods       Date:  2003-03-15       Impact factor: 2.390

5.  Morphometric analysis of the macula in eyes with disciform age-related macular degeneration.

Authors:  S Y Kim; S Sadda; J Pearlman; M S Humayun; E de Juan; B M Melia; W R Green
Journal:  Retina       Date:  2002-08       Impact factor: 4.256

6.  Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa.

Authors:  J L Stone; W E Barlow; M S Humayun; E de Juan; A H Milam
Journal:  Arch Ophthalmol       Date:  1992-11

7.  Can subretinal microphotodiodes successfully replace degenerated photoreceptors?

Authors:  E Zrenner; A Stett; S Weiss; R B Aramant; E Guenther; K Kohler; K D Miliczek; M J Seiler; H Haemmerle
Journal:  Vision Res       Date:  1999-07       Impact factor: 1.886

8.  Risk factors for age-related macular degeneration: Pooled findings from three continents.

Authors:  W Smith; J Assink; R Klein; P Mitchell; C C Klaver; B E Klein; A Hofman; S Jensen; J J Wang; P T de Jong
Journal:  Ophthalmology       Date:  2001-04       Impact factor: 12.079

9.  Epidemiology of retinitis pigmentosa in Denmark.

Authors:  Marianne Haim
Journal:  Acta Ophthalmol Scand Suppl       Date:  2002

Review 10.  Retinal prosthesis for the blind.

Authors:  Eyal Margalit; Mauricio Maia; James D Weiland; Robert J Greenberg; Gildo Y Fujii; Gustavo Torres; Duke V Piyathaisere; Thomas M O'Hearn; Wentai Liu; Gianluca Lazzi; Gislin Dagnelie; Dean A Scribner; Eugene de Juan; Mark S Humayun
Journal:  Surv Ophthalmol       Date:  2002 Jul-Aug       Impact factor: 6.048

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  14 in total

1.  Contrast Sensitivity With a Subretinal Prosthesis and Implications for Efficient Delivery of Visual Information.

Authors:  Georges Goetz; Richard Smith; Xin Lei; Ludwig Galambos; Theodore Kamins; Keith Mathieson; Alexander Sher; Daniel Palanker
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-11       Impact factor: 4.799

2.  Chapter 2 - Restoring Vision to the Blind: Optogenetics.

Authors: 
Journal:  Transl Vis Sci Technol       Date:  2014-12-30       Impact factor: 3.283

3.  Chapter 1 - Restoring Vision to the Blind: The New Age of Implanted Visual Prostheses.

Authors: 
Journal:  Transl Vis Sci Technol       Date:  2014-12-30       Impact factor: 3.283

4.  Performance of photovoltaic arrays in-vivo and characteristics of prosthetic vision in animals with retinal degeneration.

Authors:  Henri Lorach; Georges Goetz; Yossi Mandel; Xin Lei; Ludwig Galambos; Theodore I Kamins; Keith Mathieson; Philip Huie; Roopa Dalal; James S Harris; Daniel Palanker
Journal:  Vision Res       Date:  2014-09-26       Impact factor: 1.886

5.  Spatiotemporal characteristics of retinal response to network-mediated photovoltaic stimulation.

Authors:  Elton Ho; Richard Smith; Georges Goetz; Xin Lei; Ludwig Galambos; Theodore I Kamins; James Harris; Keith Mathieson; Daniel Palanker; Alexander Sher
Journal:  J Neurophysiol       Date:  2017-10-18       Impact factor: 2.714

6.  Phase-controlled, speckle-free holographic projection with applications in precision optogenetics.

Authors:  Tal Aharoni; Shy Shoham
Journal:  Neurophotonics       Date:  2018-03-15       Impact factor: 3.593

7.  Photovoltaic Restoration of Central Vision in Atrophic Age-Related Macular Degeneration.

Authors:  Daniel Palanker; Yannick Le Mer; Saddek Mohand-Said; Mahiul Muqit; Jose A Sahel
Journal:  Ophthalmology       Date:  2020-02-25       Impact factor: 12.079

8.  Interactions of Prosthetic and Natural Vision in Animals With Local Retinal Degeneration.

Authors:  Henri Lorach; Xin Lei; Ludwig Galambos; Theodore Kamins; Keith Mathieson; Roopa Dalal; Philip Huie; James Harris; Daniel Palanker
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-11       Impact factor: 4.799

Review 9.  Electronic approaches to restoration of sight.

Authors:  G A Goetz; D V Palanker
Journal:  Rep Prog Phys       Date:  2016-08-09

10.  Sensitization of ON-bipolar cells with ambient light activatable multi-characteristic opsin rescues vision in mice.

Authors:  Subrata Batabyal; Sivakumar Gajjeraman; Sanjay Pradhan; Sulagna Bhattacharya; Weldon Wright; Samarendra Mohanty
Journal:  Gene Ther       Date:  2020-10-22       Impact factor: 4.184

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