Literature DB >> 24039102

Binding of a designed anti-cancer drug to the central cavity of an RNA three-way junction.

Siriporn Phongtongpasuk1, Susann Paulus, Joachim Schnabl, Roland K O Sigel, Bernhard Spingler, Michael J Hannon, Eva Freisinger.   

Abstract

Getting to the heart of it: Co-crystallization of an RNA three-way junction with a cylindrical di-iron(II)-based anti-cancer drug (green) results in π-stacking interactions between the cylinder and the central base pairs of the RNA structure. The shape, size, and cationic nature of the cylinder were found to be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization of the RNA three-way junction by the iron(II) cylinder.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  RNA recognition; antitumor agents; bioinorganic chemistry; helicates; three-way junctions

Mesh：

Substances：

Year:  2013        PMID： 24039102     DOI： 10.1002/anie.201305079

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  18 in total

1.  Mechanistic Studies of the Anticancer Activity of An Octahedral Hexanuclear Pt(II) Cage.

Authors:  Yao-Rong Zheng; Kogularamanan Suntharalingam; Peter M Bruno; Wei Lin; Weixue Wang; Michael T Hemann; Stephen J Lippard
Journal:  Inorganica Chim Acta       Date:  2016-03-25       Impact factor: 2.545

2.  Recognition of nucleic acid junctions using triptycene-based molecules.

Authors:  Stephanie A Barros; David M Chenoweth
Journal:  Angew Chem Int Ed Engl       Date:  2014-09-24       Impact factor: 15.336

3.  Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex.

Authors:  Zhen Yu; Menglu Han; James A Cowan
Journal:  Angew Chem Int Ed Engl       Date:  2014-12-11       Impact factor: 15.336

Review 4.  Comparison of the π-stacking properties of purine versus pyrimidine residues. Some generalizations regarding selectivity.

Authors:  Astrid Sigel; Bert P Operschall; Helmut Sigel
Journal:  J Biol Inorg Chem       Date:  2014-01-25       Impact factor: 3.358

5.  A self-assembled Ru-Pt metallacage as a lysosome-targeting photosensitizer for 2-photon photodynamic therapy.

Authors:  Zhixuan Zhou; Jiangping Liu; Juanjuan Huang; Thomas W Rees; Yiliang Wang; Heng Wang; Xiaopeng Li; Hui Chao; Peter J Stang
Journal:  Proc Natl Acad Sci U S A       Date:  2019-09-23       Impact factor: 11.205

6.  Dynamic Stereoselection of Peptide Helicates and Their Selective Labeling of DNA Replication Foci in Cells*.

Authors:  Jacobo Gómez-González; Yolanda Pérez; Giuseppe Sciortino; Lorena Roldan-Martín; José Martínez-Costas; Jean-Didier Maréchal; Ignacio Alfonso; Miguel Vázquez López; M Eugenio Vázquez
Journal:  Angew Chem Int Ed Engl       Date:  2021-01-28       Impact factor: 15.336

7.  Rollover Cyclometalation vs Nitrogen Coordination in Tetrapyridyl Anticancer Gold(III) Complexes: Effect on Protein Interaction and Toxicity.

Authors:  Xue-Quan Zhou; Imma Carbo-Bague; Maxime A Siegler; Jonathan Hilgendorf; Uttara Basu; Ingo Ott; Rongfang Liu; Liyan Zhang; Vadde Ramu; Adriaan P IJzerman; Sylvestre Bonnet
Journal:  JACS Au       Date:  2021-03-16

8.  Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication*.

Authors:  Lazaros Melidis; Harriet J Hill; Nicholas J Coltman; Scott P Davies; Kinga Winczura; Tasha Chauhan; James S Craig; Aditya Garai; Catherine A J Hooper; Ross T Egan; Jane A McKeating; Nikolas J Hodges; Zania Stamataki; Pawel Grzechnik; Michael J Hannon
Journal:  Angew Chem Int Ed Engl       Date:  2021-07-09       Impact factor: 16.823

9.  Iron(II) supramolecular helicates interfere with the HIV-1 Tat-TAR RNA interaction critical for viral replication.

Authors:  Jaroslav Malina; Michael J Hannon; Viktor Brabec
Journal:  Sci Rep       Date:  2016-07-12       Impact factor: 4.379

10.  Cavity-Containing [Fe2L3]4+ Helicates: An Examination of Host-Guest Chemistry and Cytotoxicity.

Authors:  Lynn S Lisboa; Mie Riisom; Roan A S Vasdev; Stephen M F Jamieson; L James Wright; Christian G Hartinger; James D Crowley
Journal:  Front Chem       Date:  2021-07-07       Impact factor: 5.221
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