Yu Wang1, Yawei Zhang, Shuangge Ma. 1. School of Statistics, Renmin University of China, 59 Zhongguancun Avenue, Beijing 100872, China; School of Public Health, Yale University, 60 College ST, New Haven, CT 06520, USA. Electronic address: abyuer@gmail.com.
Abstract
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a malignant neoplasm arising from the mucosal epithelium of the nasopharynx. Different races can have different etiology, presentation, and progression patterns. METHODS: Data were analyzed on NPC patients in the United States reported to the SEER (Surveillance, Epidemiology, and End Results) database between 1973 and 2009. Racial groups studied included non-Hispanic whites, Hispanic whites, blacks, Asians, and others. Patient characteristics, age-adjusted incidence and mortality rates, treatment, and five-year relative survival rates were compared across races. Stratification by stage at diagnosis and histologic type was considered. Multivariate regression was conducted to evaluate the significance of racial differences. RESULTS: Patient characteristics that were significantly different across races included age at diagnosis, histologic type, in situ/malignant tumors in lifetime, stage, grade, and regional nodes positive. Incidence and mortality rates were significantly different across races, with Asians having the highest rates overall and stratified by age and/or histologic type. Asians also had the highest rate of receiving radiation only. The racial differences in treatment were significant in the multivariate stratified analysis. When stratified by stage and histologic type, Asians had the best five-year survival rates. The survival experience of other races depended on stage and type. In the multivariate analysis, the racial differences were significant. CONCLUSIONS: Analysis of the SEER data shows that racial differences exist among NPC patients in the U.S. This result can be informative to cancer epidemiologists and clinicians.
BACKGROUND:Nasopharyngeal carcinoma (NPC) is a malignant neoplasm arising from the mucosal epithelium of the nasopharynx. Different races can have different etiology, presentation, and progression patterns. METHODS: Data were analyzed on NPCpatients in the United States reported to the SEER (Surveillance, Epidemiology, and End Results) database between 1973 and 2009. Racial groups studied included non-Hispanic whites, Hispanic whites, blacks, Asians, and others. Patient characteristics, age-adjusted incidence and mortality rates, treatment, and five-year relative survival rates were compared across races. Stratification by stage at diagnosis and histologic type was considered. Multivariate regression was conducted to evaluate the significance of racial differences. RESULTS:Patient characteristics that were significantly different across races included age at diagnosis, histologic type, in situ/malignant tumors in lifetime, stage, grade, and regional nodes positive. Incidence and mortality rates were significantly different across races, with Asians having the highest rates overall and stratified by age and/or histologic type. Asians also had the highest rate of receiving radiation only. The racial differences in treatment were significant in the multivariate stratified analysis. When stratified by stage and histologic type, Asians had the best five-year survival rates. The survival experience of other races depended on stage and type. In the multivariate analysis, the racial differences were significant. CONCLUSIONS: Analysis of the SEER data shows that racial differences exist among NPCpatients in the U.S. This result can be informative to cancer epidemiologists and clinicians.
Authors: Luke M Richey; Andrew F Olshan; Jonathan George; Carol G Shores; Adam M Zanation; Trinitia Cannon; Mark C Weissler Journal: Arch Otolaryngol Head Neck Surg Date: 2006-10
Authors: Wanqing Liu; Federico Innocenti; Michael H Wu; Apurva A Desai; M Eileen Dolan; Edwin H Cook; Mark J Ratain Journal: Cancer Res Date: 2005-01-01 Impact factor: 12.701
Authors: Eduardo Netto; Hugo Santos; Luís Carvalho; José Luis Capelo-Martínez; Miguel Rito; José Cabeçadas; Margarida Roldão Journal: Rep Pract Oncol Radiother Date: 2020-07-11
Authors: Ashley O London; Liam W Gallagher; Rahul K Sharma; Daniel Spielman; Justin S Golub; Jonathan B Overdevest; Carol H Yan; Adam DeConde; David A Gudis Journal: J Neurol Surg B Skull Base Date: 2021-12-29
Authors: Jose Luis Guinot; Andrea Moya; Miguel Angel Santos; Marina Peña; Beatriz Quiles; Juan Carlos Sanchez-Relucio; Alonso La Rosa; Maria Isabel Tortajada; Leoncio Arribas Journal: Rep Pract Oncol Radiother Date: 2020-05-06
Authors: Han Wen Mak; Shan Hui Lee; Jeremy Chee; Ivan Tham; Boon Cher Goh; Siew Shuen Chao; Yew Kwang Ong; Kwok Seng Loh; Chwee Ming Lim Journal: PLoS One Date: 2015-05-12 Impact factor: 3.240
Authors: Katelyn O Stepan; Angela L Mazul; S Andrew Skillington; Randal C Paniello; Jason T Rich; Jose P Zevallos; Ryan S Jackson; Patrik Pipkorn; Sean Massa; Sidharth V Puram Journal: Head Neck Date: 2021-02-23 Impact factor: 3.821