Randi J Bertelsen1, Anne Lise Brantsæter2, Maria C Magnus3, Margaretha Haugen2, Ronny Myhre4, Bo Jacobsson5, Matthew P Longnecker6, Helle M Meltzer2, Stephanie J London6. 1. Department of Food, Water and Cosmetics, Norwegian Institute of Public Health, Oslo, Norway; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC. Electronic address: randi.jacobsen.bertelsen@fhi.no. 2. Department of Exposure and Risk Assessment, Norwegian Institute of Public Health, Oslo, Norway. 3. Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC; Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway. 4. Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway. 5. Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway; Department of Obstetrics and Gynecology, Sahlgrenska Academy, Gothenburg, Sweden. 6. Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC.
Abstract
BACKGROUND: Whether probiotics, which can influence the microbiome, prevent infant eczema or allergic disease remains an open question. Most studies have focused on high-risk infants. OBJECTIVES: We sought to assess whether consumption of probiotic milk products protects against atopic eczema, rhinoconjunctivitis, and asthma in early childhood in a large population-based pregnancy cohort (the Norwegian Mother and Child Cohort study). METHODS: We examined associations between consumption of probiotic milk products in pregnancy and infancy with questionnaire-reported atopic eczema, rhinoconjunctivitis, and asthma in 40,614 children. Relative risks (RRs) were calculated by using general linear models adjusted for potential confounders. RESULTS: Consumption of probiotic milk in pregnancy was associated with a slightly reduced relative risk (RR) of atopic eczema at 6 months (adjusted RR, 0.94; 95% CI, 0.89-0.99) and of rhinoconjunctivitis between 18 and 36 months (adjusted RR, 0.87; 95% CI, 0.78-0.98) compared with no consumption during pregnancy. Maternal history of allergic disease did not notably influence the associations. When both the mother (during pregnancy) and infant (after 6 months of age) had consumed probiotic milk, the adjusted RR of rhinoconjunctivitis was 0.80 (95% CI, 0.68-0.93) relative to no consumption by either. Probiotic milk consumption was not associated with asthma at 36 months. CONCLUSIONS: In this population-based cohort consumption of probiotic milk products was related to a reduced incidence of atopic eczema and rhinoconjunctivitis, but no association was seen for incidence of asthma by 36 months of age. Published by Mosby, Inc.
BACKGROUND: Whether probiotics, which can influence the microbiome, prevent infanteczema or allergic disease remains an open question. Most studies have focused on high-risk infants. OBJECTIVES: We sought to assess whether consumption of probiotic milk products protects against atopic eczema, rhinoconjunctivitis, and asthma in early childhood in a large population-based pregnancy cohort (the Norwegian Mother and Child Cohort study). METHODS: We examined associations between consumption of probiotic milk products in pregnancy and infancy with questionnaire-reported atopic eczema, rhinoconjunctivitis, and asthma in 40,614 children. Relative risks (RRs) were calculated by using general linear models adjusted for potential confounders. RESULTS: Consumption of probiotic milk in pregnancy was associated with a slightly reduced relative risk (RR) of atopic eczema at 6 months (adjusted RR, 0.94; 95% CI, 0.89-0.99) and of rhinoconjunctivitis between 18 and 36 months (adjusted RR, 0.87; 95% CI, 0.78-0.98) compared with no consumption during pregnancy. Maternal history of allergic disease did not notably influence the associations. When both the mother (during pregnancy) and infant (after 6 months of age) had consumed probiotic milk, the adjusted RR of rhinoconjunctivitis was 0.80 (95% CI, 0.68-0.93) relative to no consumption by either. Probiotic milk consumption was not associated with asthma at 36 months. CONCLUSIONS: In this population-based cohort consumption of probiotic milk products was related to a reduced incidence of atopic eczema and rhinoconjunctivitis, but no association was seen for incidence of asthma by 36 months of age. Published by Mosby, Inc.
Entities:
Keywords:
Allergy; BMI; Body mass index; FFQ; Food frequency questionnaire; MJ; Megajoules; MoBa; Norwegian Mother and Child Cohort Study; RR; Relative risk; asthma; eczema; microbiome; probiotics; rhinoconjunctivitis
Authors: Regan L Bailey; Jaime J Gahche; Cindy V Lentino; Johanna T Dwyer; Jody S Engel; Paul R Thomas; Joseph M Betz; Christopher T Sempos; Mary Frances Picciano Journal: J Nutr Date: 2010-12-22 Impact factor: 4.798
Authors: Lavinia Paternoster; Marie Standl; Chih-Mei Chen; Adaikalavan Ramasamy; Klaus Bønnelykke; Liesbeth Duijts; Manuel A Ferreira; Alexessander Couto Alves; Jacob P Thyssen; Eva Albrecht; Hansjörg Baurecht; Bjarke Feenstra; Patrick M A Sleiman; Pirro Hysi; Nicole M Warrington; Ivan Curjuric; Ronny Myhre; John A Curtin; Maria M Groen-Blokhuis; Marjan Kerkhof; Annika Sääf; Andre Franke; David Ellinghaus; Regina Fölster-Holst; Emmanouil Dermitzakis; Stephen B Montgomery; Holger Prokisch; Katharina Heim; Anna-Liisa Hartikainen; Anneli Pouta; Juha Pekkanen; Alexandra I F Blakemore; Jessica L Buxton; Marika Kaakinen; David L Duffy; Pamela A Madden; Andrew C Heath; Grant W Montgomery; Philip J Thompson; Melanie C Matheson; Peter Le Souëf; Beate St Pourcain; George Davey Smith; John Henderson; John P Kemp; Nicholas J Timpson; Panos Deloukas; Susan M Ring; H-Erich Wichmann; Martina Müller-Nurasyid; Natalija Novak; Norman Klopp; Elke Rodríguez; Wendy McArdle; Allan Linneberg; Torkil Menné; Ellen A Nohr; Albert Hofman; André G Uitterlinden; Cornélia M van Duijn; Fernando Rivadeneira; Johan C de Jongste; Ralf J P van der Valk; Matthias Wjst; Rain Jogi; Frank Geller; Heather A Boyd; Jeffrey C Murray; Cecilia Kim; Frank Mentch; Michael March; Massimo Mangino; Tim D Spector; Veronique Bataille; Craig E Pennell; Patrick G Holt; Peter Sly; Carla M T Tiesler; Elisabeth Thiering; Thomas Illig; Medea Imboden; Wenche Nystad; Angela Simpson; Jouke-Jan Hottenga; Dirkje Postma; Gerard H Koppelman; Henriette A Smit; Cilla Söderhäll; Bo Chawes; Eskil Kreiner-Møller; Hans Bisgaard; Erik Melén; Dorret I Boomsma; Adnan Custovic; Bo Jacobsson; Nicole M Probst-Hensch; Lyle J Palmer; Daniel Glass; Hakon Hakonarson; Mads Melbye; Deborah L Jarvis; Vincent W V Jaddoe; Christian Gieger; David P Strachan; Nicholas G Martin; Marjo-Riitta Jarvelin; Joachim Heinrich; David M Evans; Stephan Weidinger Journal: Nat Genet Date: 2011-12-25 Impact factor: 38.330
Authors: Melody J Slashinski; Sheryl A McCurdy; Laura S Achenbaum; Simon N Whitney; Amy L McGuire Journal: BMC Med Ethics Date: 2012-10-30 Impact factor: 2.652
Authors: Shreyas V Kumbhare; Dhrati V V Patangia; Ravindra H Patil; Yogesh S Shouche; Nitinkumar P Patil Journal: J Biosci Date: 2019-06 Impact factor: 1.826
Authors: Carina Venter; Carlo Agostoni; S Hasan Arshad; Miriam Ben-Abdallah; George Du Toit; David M Fleischer; Matthew Greenhawt; Deborah H Glueck; Marion Groetch; Nonhlanhla Lunjani; Kate Maslin; Alexander Maiorella; Rosan Meyer; Muraro Antonella; Merryn J Netting; Bright Ibeabughichi Nwaru; Debra J Palmer; Micheala P Palumbo; Graham Roberts; Caroline Roduit; Pete Smith; Eva Untersmayr; Lauren A Vanderlinden; Liam O'Mahony Journal: Pediatr Allergy Immunol Date: 2020-08-06 Impact factor: 5.464
Authors: Sara M Parigi; Maria Eldh; Pia Larssen; Susanne Gabrielsson; Eduardo J Villablanca Journal: Front Immunol Date: 2015-08-19 Impact factor: 7.561