AIMS/HYPOTHESIS: The aim of the study was to compare longitudinal changes in insulin sensitivity (SI) and beta cell function between women with and without a history of gestational diabetes mellitus (GDM). METHODS: The prospective follow-up cohort included 235 parous non-diabetic Mexican-American women, 93 with and 142 without a history of GDM. The participants underwent dual-energy x-ray absorptiometry, OGTTs and IVGTTs at baseline and at a median of 4.1 years follow-up. The baseline values and rates of change of metabolic measures were compared between groups. RESULTS: At baseline, women with prior GDM (mean age 36.3 years) had similar values of SI but higher percentages of body fat and trunk fat (p ≤ 0.02), a lower acute insulin response and poorer beta cell compensation (disposition index [DI]) (p < 0.0001) than women without GDM (mean age 37.9 years). During the follow-up, women with GDM had a faster decline in SI (p = 0.02) and DI (p = 0.02) than their counterparts without GDM, with no significant differences in changes of weight or fat (p > 0.50). Adjustment for baseline age, adiposity, calorie intake, physical activity, age at first pregnancy, additional pregnancies and changes in adiposity during follow-up increased the between-group differences in the rates of change of SI and DI (p ≤ 0.003). CONCLUSIONS/ INTERPRETATION: Mexican-American women with recent GDM had a faster deterioration in insulin sensitivity and beta cell compensation than their parous counterparts without GDM. The differences were not explained by differences in adiposity, suggesting more deleterious effects of existing fat and/or reduced beta cell robustness in women with GDM.
AIMS/HYPOTHESIS: The aim of the study was to compare longitudinal changes in insulin sensitivity (SI) and beta cell function between women with and without a history of gestational diabetes mellitus (GDM). METHODS: The prospective follow-up cohort included 235 parous non-diabetic Mexican-American women, 93 with and 142 without a history of GDM. The participants underwent dual-energy x-ray absorptiometry, OGTTs and IVGTTs at baseline and at a median of 4.1 years follow-up. The baseline values and rates of change of metabolic measures were compared between groups. RESULTS: At baseline, women with prior GDM (mean age 36.3 years) had similar values of SI but higher percentages of body fat and trunk fat (p ≤ 0.02), a lower acute insulin response and poorer beta cell compensation (disposition index [DI]) (p < 0.0001) than women without GDM (mean age 37.9 years). During the follow-up, women with GDM had a faster decline in SI (p = 0.02) and DI (p = 0.02) than their counterparts without GDM, with no significant differences in changes of weight or fat (p > 0.50). Adjustment for baseline age, adiposity, calorie intake, physical activity, age at first pregnancy, additional pregnancies and changes in adiposity during follow-up increased the between-group differences in the rates of change of SI and DI (p ≤ 0.003). CONCLUSIONS/ INTERPRETATION: Mexican-American women with recent GDM had a faster deterioration in insulin sensitivity and beta cell compensation than their parous counterparts without GDM. The differences were not explained by differences in adiposity, suggesting more deleterious effects of existing fat and/or reduced beta cell robustness in women with GDM.
Authors: A H Xiang; B H Li; M H Black; D A Sacks; T A Buchanan; S J Jacobsen; J M Lawrence Journal: Diabetologia Date: 2011-10-21 Impact factor: 10.122
Authors: Ute Nöthlings; Lynne R Wilkens; Suzanne P Murphy; Jean H Hankin; Brian E Henderson; Laurence N Kolonel Journal: Cancer Causes Control Date: 2007-01-11 Impact factor: 2.506
Authors: Richard M Watanabe; Hooman Allayee; Anny H Xiang; Enrique Trigo; Jaana Hartiala; Jean M Lawrence; Thomas A Buchanan Journal: Diabetes Date: 2007-02-22 Impact factor: 9.461
Authors: Xia Li; Hooman Allayee; Anny H Xiang; Enrique Trigo; Jaana Hartiala; Jean M Lawrence; Thomas A Buchanan; Richard M Watanabe Journal: Obesity (Silver Spring) Date: 2009-01-15 Impact factor: 5.002
Authors: Robert E Ratner; Costas A Christophi; Boyd E Metzger; Dana Dabelea; Peter H Bennett; Xavier Pi-Sunyer; Sarah Fowler; Steven E Kahn Journal: J Clin Endocrinol Metab Date: 2008-09-30 Impact factor: 5.958
Authors: Ravi Retnakaran; Ying Qi; Mathew Sermer; Philip W Connelly; Anthony J G Hanley; Bernard Zinman Journal: Diabetes Care Date: 2010-05-18 Impact factor: 17.152
Authors: Yu-Hsiang Shu; Jaana Hartiala; Anny H Xiang; Enrique Trigo; Jean M Lawrence; Hooman Allayee; Thomas A Buchanan; Nunzio Bottini; Richard M Watanabe Journal: J Clin Endocrinol Metab Date: 2009-07-21 Impact factor: 5.958
Authors: Mary Helen Black; Jun Wu; Miwa Takayanagi; Nan Wang; Kent D Taylor; Talin Haritunians; Enrique Trigo; Jean M Lawrence; Richard M Watanabe; Thomas A Buchanan; Anny H Xiang Journal: J Clin Endocrinol Metab Date: 2015-01-13 Impact factor: 5.958
Authors: Alessandro Volpe; Chang Ye; Anthony J Hanley; Philip W Connelly; Bernard Zinman; Ravi Retnakaran Journal: J Clin Endocrinol Metab Date: 2020-03-01 Impact factor: 5.958
Authors: M Hill; A Pařízek; P Šimják; M Koucký; K Anderlová; H Krejčí; D Vejražková; L Ondřejíková; A Černý; R Kancheva Journal: Physiol Res Date: 2021-12-30 Impact factor: 2.139
Authors: Alexandra E Butler; Sangeeta Dhawan; Jonathan Hoang; Megan Cory; Kylie Zeng; Helga Fritsch; Juris J Meier; Robert A Rizza; Peter C Butler Journal: J Clin Endocrinol Metab Date: 2015-12-23 Impact factor: 5.958
Authors: Yvonne Winhofer; Andrea Tura; Anita Thomas; Thomas Prikoszovich; Christine Winzer; Giovanni Pacini; Anton Luger; Alexandra Kautzky-Willer Journal: Int J Endocrinol Date: 2015-03-22 Impact factor: 3.257
Authors: Diana L Shuster; Laura M Shireman; Xiaosu Ma; Danny D Shen; Shannon K Flood Nichols; Mahmoud S Ahmed; Shannon Clark; Steve Caritis; Raman Venkataramanan; David M Haas; Sara K Quinney; Laura S Haneline; Alan T Tita; Tracy A Manuck; Kenneth E Thummel; Linda Morris Brown; Zhaoxia Ren; Zane Brown; Thomas R Easterling; Mary F Hebert Journal: Clin Pharmacol Ther Date: 2020-01-25 Impact factor: 6.875