CONTEXT: Acid phosphatase locus 1 (ACP1) is a low molecular weight tyrosine phosphatase that has been shown to be an important regulator of insulin receptor signaling. OBJECTIVE: We tested whether variation in ACP1 is associated with type 2 diabetes-related traits in 1035 individuals in 339 Mexican-American families of probands with or without a previous diagnosis of gestational diabetes mellitus (GDM). DESIGN: Study participants were phenotyped by oral glucose tolerance test (for glucose and insulin level) and iv glucose tolerance test (for insulin sensitivity and acute insulin response) and had dual-energy x-ray absorptiometry scans to assess body composition. Six tag single nucleotide polymorphisms (SNPs) were identified from among 15 SNPs genotyped across the ACP1 region. SNPs were tested for association with phenotypes using a likelihood ratio test under a variance components framework. RESULTS: After Bonferroni correction, none of the SNPs were associated with type 2 diabetes mellitus-related phenotypes. However, we observed a significant sex-specific effect of rs3828329. Among males, rs3828329 was significantly associated with fasting insulin (Bonferroni P = 0.007) and insulin sensitivity (Bonferroni P = 0.019) and marginally associated with 2-h insulin (Bonferroni P = 0.058) and percentage body fat (Bonferroni P = 0.09). CONCLUSIONS: There were no significant associations in females. We conclude that variation in ACP1 is associated with fasting insulin and insulin sensitivity in a sex-specific manner.
CONTEXT: Acid phosphatase locus 1 (ACP1) is a low molecular weight tyrosine phosphatase that has been shown to be an important regulator of insulin receptor signaling. OBJECTIVE: We tested whether variation in ACP1 is associated with type 2 diabetes-related traits in 1035 individuals in 339 Mexican-American families of probands with or without a previous diagnosis of gestational diabetes mellitus (GDM). DESIGN: Study participants were phenotyped by oral glucose tolerance test (for glucose and insulin level) and iv glucose tolerance test (for insulin sensitivity and acute insulin response) and had dual-energy x-ray absorptiometry scans to assess body composition. Six tag single nucleotide polymorphisms (SNPs) were identified from among 15 SNPs genotyped across the ACP1 region. SNPs were tested for association with phenotypes using a likelihood ratio test under a variance components framework. RESULTS: After Bonferroni correction, none of the SNPs were associated with type 2 diabetes mellitus-related phenotypes. However, we observed a significant sex-specific effect of rs3828329. Among males, rs3828329 was significantly associated with fasting insulin (Bonferroni P = 0.007) and insulin sensitivity (Bonferroni P = 0.019) and marginally associated with 2-h insulin (Bonferroni P = 0.058) and percentage body fat (Bonferroni P = 0.09). CONCLUSIONS: There were no significant associations in females. We conclude that variation in ACP1 is associated with fasting insulin and insulin sensitivity in a sex-specific manner.
Authors: Stacey B Gabriel; Stephen F Schaffner; Huy Nguyen; Jamie M Moore; Jessica Roy; Brendan Blumenstiel; John Higgins; Matthew DeFelice; Amy Lochner; Maura Faggart; Shau Neen Liu-Cordero; Charles Rotimi; Adebowale Adeyemo; Richard Cooper; Ryk Ward; Eric S Lander; Mark J Daly; David Altshuler Journal: Science Date: 2002-05-23 Impact factor: 47.728
Authors: G Faggioni; P Borgiani; N Bottini; F Gloria-Bottini; F Tontoli; V Contreas; E Bottini; F Lista Journal: Ann Hum Genet Date: 2002-07 Impact factor: 1.670
Authors: N Bottini; G F Meloni; P Borgiani; A Giorgini; R Buzzetti; P Pozzilli; P Lucarelli; F Gloria-Bottini Journal: Metabolism Date: 2002-04 Impact factor: 8.694
Authors: M L Taddei; P Chiarugi; P Cirri; D Talini; G Camici; G Manao; G Raugei; G Ramponi Journal: Biochem Biophys Res Commun Date: 2000-04-13 Impact factor: 3.575
Authors: Andres Alonso; Joanna Sasin; Nunzio Bottini; Ilan Friedberg; Iddo Friedberg; Andrei Osterman; Adam Godzik; Tony Hunter; Jack Dixon; Tomas Mustelin Journal: Cell Date: 2004-06-11 Impact factor: 41.582
Authors: Mary Helen Black; Richard M Watanabe; Enrique Trigo; Miwa Takayanagi; Jean M Lawrence; Thomas A Buchanan; Anny H Xiang Journal: J Nutr Date: 2013-01-23 Impact factor: 4.798
Authors: Anny H Xiang; Miwa Takayanagi; Mary Helen Black; Enrique Trigo; Jean M Lawrence; Richard M Watanabe; Thomas A Buchanan Journal: Diabetologia Date: 2013-09-13 Impact factor: 10.122
Authors: Corinna Koebnick; Mary Helen Black; Jun Wu; Yu-Hsiang Shu; Adrienne W MacKay; Richard M Watanabe; Thomas A Buchanan; Anny H Xiang Journal: Br J Nutr Date: 2018-10-30 Impact factor: 3.718
Authors: Chuan Gao; Nan Wang; Xiuqing Guo; Julie T Ziegler; Kent D Taylor; Anny H Xiang; Yang Hai; Steven J Kridel; Jerry L Nadler; Fouad Kandeel; Leslie J Raffel; Yii-Der I Chen; Jill M Norris; Jerome I Rotter; Richard M Watanabe; Lynne E Wagenknecht; Donald W Bowden; Elizabeth K Speliotes; Mark O Goodarzi; Carl D Langefeld; Nicholette D Palmer Journal: PLoS One Date: 2015-11-24 Impact factor: 3.240
Authors: Chuan Gao; Keri L Tabb; Latchezar M Dimitrov; Kent D Taylor; Nan Wang; Xiuqing Guo; Jirong Long; Jerome I Rotter; Richard M Watanabe; Joanne E Curran; John Blangero; Carl D Langefeld; Donald W Bowden; Nicholette D Palmer Journal: Sci Rep Date: 2018-04-04 Impact factor: 4.379