Literature DB >> 24029445

Understanding cognitive deficits in Alzheimer's disease based on neuroimaging findings.

Meredith N Braskie1, Paul M Thompson.   

Abstract

Brain amyloid can be measured using positron emission tomography (PET). There are mixed reports regarding whether amyloid measures are correlated with measures of cognition (in particular memory), depending on the cohorts and cognitive domains assessed. In Alzheimer's disease (AD) patients and those at heightened risk for AD, cognitive performance may be related to the level and extent of classical AD pathology (amyloid plaques and neurofibrillary angles), but it is also influenced by neurodegeneration, neurocognitive reserve, and vascular health. We discuss what recent neuroimaging research has discovered about cognitive deficits in AD and offer suggestions for future research.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  MRI; PET; dementia; executive function; memory; mild cognitive impairment

Mesh：

Substances：

Year:  2013        PMID： 24029445      PMCID： PMC3947610          DOI： 10.1016/j.tics.2013.08.007

Source DB:  PubMed          Journal:  Trends Cogn Sci        ISSN： 1364-6613            Impact factor:   20.229


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