| Literature DB >> 24025122 |
Aaron D Lackner1, Andrew V Samant, F Dean Toste.
Abstract
The single-operation deracemization of 3H indolines and tetrahydroquinolines is described. An asymmetric redox approach was employed, in which a phosphoric acid catalyst, oxidant, and reductant are present in the reaction mixture. The simultaneous presence of both oxidant and reductant was enabled by phase separation and resulted in the isolation of highly enantioenriched starting materials in high yields.Entities:
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Year: 2013 PMID： 24025122 PMCID： PMC3827023 DOI： 10.1021/ja4082827
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419