Literature DB >> 24023603

Role of leptin in autoimmune diseases.

Manole Cojocaru1, Inimioara Mihaela Cojocaru, Isabela Siloşi, Suzana Rogoz.   

Abstract

Leptin represents a link between metabolism, nutritional status, and immune responses. Leptin is important for optimal functioning of the immune system. Leptin is a cytokine-like hormone with proinflammatory properties linked to autoimmune diseases. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. Leptin has been shown to enhance immune reactions in autoimmune diseases that are commonly associated with inflammatory responses. Both high and low levels of leptin might contribute to autoimmune diseases. Leptin has been explored as a potential target for therapeutic development in treating autoimmune diseases. In this review, we review here the most recent advances on the role of leptin in autoimmunity and in immune-rheumatological diseases.

Entities:  

Keywords:  autoimmune diseases; autoimmunity; leptin; pathophysiology

Year:  2013        PMID： 24023603      PMCID： PMC3749767     

Source DB:  PubMed          Journal:  Maedica (Bucur)        ISSN： 1841-9038


  38 in total

1.  Leptin and ANCA-associated vasculitis: a healthy link?

Authors:  M Thewissen; J W Cohen Tervaert
Journal:  Rheumatology (Oxford)       Date:  2008-02-11       Impact factor: 7.580

2.  Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta.

Authors:  Anna Paola Batocchi; Mario Rotondi; Marcella Caggiula; Giovanni Frisullo; Francesca Odoardi; Viviana Nociti; Carlo Carella; Pietro Attilio Tonali; Massimiliano Mirabella
Journal:  J Neuroimmunol       Date:  2003-06       Impact factor: 3.478

Review 3.  Leptin in immuno-rheumatological diseases.

Authors:  Marta Vadacca; Domenico P E Margiotta; Luca Navarini; Antonella Afeltra
Journal:  Cell Mol Immunol       Date:  2011-03-14       Impact factor: 11.530

Review 4.  Leptin in immunology.

Authors:  Giuseppe Matarese; Stergios Moschos; Christos S Mantzoros
Journal:  J Immunol       Date:  2005-03-15       Impact factor: 5.422

5.  Independent association between plasma leptin and C-reactive protein in healthy humans.

Authors:  Abu S M Shamsuzzaman; Mikolaj Winnicki; Robert Wolk; Anna Svatikova; Bradley G Phillips; Diane E Davison; Peter B Berger; Virend K Somers
Journal:  Circulation       Date:  2004-04-26       Impact factor: 29.690

6.  Changes in serum leptin in lean and obese subjects with acute hyperglycemic crises.

Authors:  Abbas E Kitabchi; Guillermo E Umpierrez
Journal:  J Clin Endocrinol Metab       Date:  2003-06       Impact factor: 5.958

7.  Serum leptin in systemic lupus erythematosus.

Authors:  M Wisłowska; M Rok; K Stepień; A Kuklo-Kowalska
Journal:  Rheumatol Int       Date:  2008-01-15       Impact factor: 2.631

8.  Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells.

Authors:  Giuseppe Matarese; Pietro Biagio Carrieri; Antonio La Cava; Francesco Perna; Veronica Sanna; Veronica De Rosa; Daniela Aufiero; Silvia Fontana; Serafino Zappacosta
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-23       Impact factor: 11.205

Review 9.  Leptin in the regulation of immunity, inflammation, and hematopoiesis.

Authors:  G Fantuzzi; R Faggioni
Journal:  J Leukoc Biol       Date:  2000-10       Impact factor: 4.962

Review 10.  Leptin: structure, function and biology.

Authors:  Faming Zhang; Yanyun Chen; Mark Heiman; Richard Dimarchi
Journal:  Vitam Horm       Date:  2005       Impact factor: 3.421
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  9 in total

1.  Metabolic syndrome in Sjögren's syndrome patients: a relevant concern for clinical monitoring.

Authors:  Kristopherson Lustosa Augusto; Eloisa Bonfa; Rosa Maria Rodrigues Pereira; Cleonice Bueno; Elaine Pires Leon; Vilma Santos Trindade Viana; Sandra Gofinet Pasoto
Journal:  Clin Rheumatol       Date:  2015-09-14       Impact factor: 2.980

2.  Primed Mycobacterial Uveitis (PMU): Histologic and Cytokine Characterization of a Model of Uveitis in Rats.

Authors:  Kathryn L Pepple; Lauren Rotkis; Jennifer Van Grol; Leslie Wilson; Angela Sandt; Deborah L Lam; Eric Carlson; Russell N Van Gelder
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-12       Impact factor: 4.799

Review 3.  Spexin status in relation to obesity and its related comorbidities: a systematic review.

Authors:  Maryam Behrooz; Elnaz Vaghef-Mehrabany; Vahid Maleki; Samira Pourmoradian; Zahra Fathifar; Alireza Ostadrahimi
Journal:  J Diabetes Metab Disord       Date:  2020-11-07

4.  Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation.

Authors:  Chun-Jung Huang; Matthew J McAllister; Aaron L Slusher; Heather E Webb; J Thomas Mock; Edmund O Acevedo
Journal:  Sports Med Open       Date:  2015-09-23

Review 5.  Psychoneuroimmunoendocrinology: clinical implications.

Authors:  Sandra Nora González-Díaz; Alfredo Arias-Cruz; Bárbara Elizondo-Villarreal; Olga Patricia Monge-Ortega
Journal:  World Allergy Organ J       Date:  2017-06-06       Impact factor: 4.084

6.  Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis.

Authors:  Małgorzata Michalska-Jakubus; Karolina Sawicka; Emilia Potembska; Małgorzata Kowal; Dorota Krasowska
Journal:  Postepy Dermatol Alergol       Date:  2018-05-16       Impact factor: 1.837

7.  Toll-Like Receptors-2 and -4 in Graves' Disease-Key Players or Bystanders?

Authors:  Agnieszka Polak; Ewelina Grywalska; Janusz Klatka; Jacek Roliński; Beata Matyjaszek-Matuszek; Maria Klatka
Journal:  Int J Mol Sci       Date:  2019-09-24       Impact factor: 5.923

Review 8.  Life factors acting on systemic lupus erythematosus.

Authors:  Jiaxuan Chen; Shuzhen Liao; Wanxian Pang; Fengbiao Guo; Lawei Yang; Hua-Feng Liu; Qingjun Pan
Journal:  Front Immunol       Date:  2022-09-15       Impact factor: 8.786

9.  Associations of Spexin and cardiometabolic parameters among women with and without gestational diabetes mellitus.

Authors:  Nasser M Al-Daghri; Hazim A Al-Hazmi; Abdulrahman Al-Ajlan; Mohammad S Masoud; Abeer Al-Amro; Amani Al-Ghamdi; Abdullah M Alnaami; Omar S Al-Attas; Majed S Alokail
Journal:  Saudi J Biol Sci       Date:  2018-01-20       Impact factor: 4.219
  9 in total

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