Luisa A Wetta1, Joseph R Biggio1, Suzanne Cliver1, Adi Abramovici1, Stephen Barnes2, Alan T N Tita1. 1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama. 2. Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama.
Abstract
OBJECTIVE: The objective of this study is to evaluate whether midtrimester maternal vitamin D is associated with preeclampsia < 37 weeks or spontaneous preterm birth (SPTB) < 35 weeks. STUDY DESIGN: Nested case-control comprising two case subsets: (1) 100 women with preeclampsia < 37 weeks and (2) 100 women with SPB < 35 weeks. Controls consisted of 200 women delivered between 39 and 40 weeks. Stored maternal serum obtained between 15 and 21 weeks was tested for total 25-hydroxy vitamin D (25-OH D) levels using liquid chromatography-tandem mass spectrometry. Mean 25-OH D levels and prevalence of vitamin D insufficiency (25-OH D < 30 ng/mL) and deficiency (25-OH D < 15 ng/mL) were compared. RESULTS: In this study, 89 preeclampsia, 90 SPTB cases, and 177 controls had valid measurements. Mean midtrimester vitamin D was not significantly different between women with preeclampsia (27.4 ng/mL ± 14.4) and controls (28.6 ± 12.6) (p = 0.46), or SPTB (28.8 ± 13.2) and controls (p = 0.92). After adjusting for potential cofounders, neither vitamin D insufficiency (adjusted odds ratio [OR], 1.1; 95% confidence interval [CI], 0.6-2.0) nor deficiency (adjusted OR, 1.4; 95% CI, 0.7-3.0) was significantly associated with preeclampsia. Likewise, SPTB was not significantly associated with either vitamin D insufficiency or deficiency (adjusted OR, 0.8; 95% CI, 0.4-1.4, adjusted OR, 1.3 or 95% CI, 0.6-3.0, respectively). CONCLUSION: Midtrimester maternal vitamin D was not significantly associated with preeclampsia < 37 weeks or SPTB < 35 weeks. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
OBJECTIVE: The objective of this study is to evaluate whether midtrimester maternal vitamin D is associated with preeclampsia < 37 weeks or spontaneous preterm birth (SPTB) < 35 weeks. STUDY DESIGN: Nested case-control comprising two case subsets: (1) 100 women with preeclampsia < 37 weeks and (2) 100 women with SPB < 35 weeks. Controls consisted of 200 women delivered between 39 and 40 weeks. Stored maternal serum obtained between 15 and 21 weeks was tested for total 25-hydroxy vitamin D (25-OH D) levels using liquid chromatography-tandem mass spectrometry. Mean 25-OH D levels and prevalence of vitamin Dinsufficiency (25-OH D < 30 ng/mL) and deficiency (25-OH D < 15 ng/mL) were compared. RESULTS: In this study, 89 preeclampsia, 90 SPTB cases, and 177 controls had valid measurements. Mean midtrimester vitamin D was not significantly different between women with preeclampsia (27.4 ng/mL ± 14.4) and controls (28.6 ± 12.6) (p = 0.46), or SPTB (28.8 ± 13.2) and controls (p = 0.92). After adjusting for potential cofounders, neither vitamin Dinsufficiency (adjusted odds ratio [OR], 1.1; 95% confidence interval [CI], 0.6-2.0) nor deficiency (adjusted OR, 1.4; 95% CI, 0.7-3.0) was significantly associated with preeclampsia. Likewise, SPTB was not significantly associated with either vitamin Dinsufficiency or deficiency (adjusted OR, 0.8; 95% CI, 0.4-1.4, adjusted OR, 1.3 or 95% CI, 0.6-3.0, respectively). CONCLUSION: Midtrimester maternal vitamin D was not significantly associated with preeclampsia < 37 weeks or SPTB < 35 weeks. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Authors: Lisa M Bodnar; Janet M Catov; Hyagriv N Simhan; Michael F Holick; Robert W Powers; James M Roberts Journal: J Clin Endocrinol Metab Date: 2007-05-29 Impact factor: 5.958
Authors: Carlos A Camargo; Sheryl L Rifas-Shiman; Augusto A Litonjua; Janet W Rich-Edwards; Scott T Weiss; Diane R Gold; Ken Kleinman; Matthew W Gillman Journal: Am J Clin Nutr Date: 2007-03 Impact factor: 7.045
Authors: Greta Snellman; Håkan Melhus; Rolf Gedeborg; Liisa Byberg; Lars Berglund; Lisa Wernroth; Karl Michaëlsson Journal: PLoS One Date: 2010-07-13 Impact factor: 3.240
Authors: Heather H Burris; Sheryl L Rifas-Shiman; Susanna Y Huh; Ken Kleinman; Augusto A Litonjua; Emily Oken; Janet W Rich-Edwards; Carlos A Camargo; Matthew W Gillman Journal: Ann Epidemiol Date: 2014-02-15 Impact factor: 3.797
Authors: Julia Knabl; Aurelia Vattai; Yao Ye; Julia Jueckstock; Stefan Hutter; Franz Kainer; Sven Mahner; Udo Jeschke Journal: Int J Mol Sci Date: 2017-11-06 Impact factor: 5.923