PURPOSE: Currently, 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)F-FDG) is the gold standard radiotracer for staging of head and neck cancer; however, the low sensitivity of this tracer can impede detection of early lesions. (64)Cu-liposomes accumulate in various cancers and provide both a sensitive tracer and an indication of the biodistribution of nanotherapeutics. Here, the accumulation of (64)Cu-liposomes in early and established cancers is assessed and compared with (18)F-FDG in a head and neck cancer model. METHODS: Lesions ranging from mild dysplasia to squamous cell carcinoma were induced in a hamster model of head and neck cancer by topical application of 7,12-dimethylbenz[a]anthracene to the buccal pouch. The hamsters were imaged with micro-positron emission tomography using (18)F-FDG and (64)Cu-liposomes. RESULTS: At 24 h postinjection, (64)Cu-liposome accumulation exceeded the accumulation of (18)F-FDG in every pathologic grade. The lesion-to-cheek pouch (background) ratio and lesion-to-brain ratio were also higher for (64)Cu-liposomes than for (18)F-FDG. CONCLUSION: Imaging of a nanotracer such as (64)Cu-liposomes can improve the visualization of head and neck tumors. Accumulation of liposomal particles in head and neck tumors over various pathologic grades averaged 3.5%ID/cc demonstrating the potential for liposomal therapy with targeted chemotherapeutic agents.
PURPOSE: Currently, 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)F-FDG) is the gold standard radiotracer for staging of head and neck cancer; however, the low sensitivity of this tracer can impede detection of early lesions. (64)Cu-liposomes accumulate in various cancers and provide both a sensitive tracer and an indication of the biodistribution of nanotherapeutics. Here, the accumulation of (64)Cu-liposomes in early and established cancers is assessed and compared with (18)F-FDG in a head and neck cancer model. METHODS: Lesions ranging from mild dysplasia to squamous cell carcinoma were induced in a hamster model of head and neck cancer by topical application of 7,12-dimethylbenz[a]anthracene to the buccal pouch. The hamsters were imaged with micro-positron emission tomography using (18)F-FDG and (64)Cu-liposomes. RESULTS: At 24 h postinjection, (64)Cu-liposome accumulation exceeded the accumulation of (18)F-FDG in every pathologic grade. The lesion-to-cheek pouch (background) ratio and lesion-to-brain ratio were also higher for (64)Cu-liposomes than for (18)F-FDG. CONCLUSION: Imaging of a nanotracer such as (64)Cu-liposomes can improve the visualization of head and neck tumors. Accumulation of liposomal particles in head and neck tumors over various pathologic grades averaged 3.5%ID/cc demonstrating the potential for liposomal therapy with targeted chemotherapeutic agents.
Authors: Hua Zhang; Jiro Kusunose; Azadeh Kheirolomoom; Jai W Seo; Jinyi Qi; Katherine D Watson; Heather A Lindfors; Erkki Ruoslahti; Julie L Sutcliffe; Katherine W Ferrara Journal: Biomaterials Date: 2008-02-06 Impact factor: 12.479
Authors: Anil K Chaturvedi; Eric A Engels; Ruth M Pfeiffer; Brenda Y Hernandez; Weihong Xiao; Esther Kim; Bo Jiang; Marc T Goodman; Maria Sibug-Saber; Wendy Cozen; Lihua Liu; Charles F Lynch; Nicolas Wentzensen; Richard C Jordan; Sean Altekruse; William F Anderson; Philip S Rosenberg; Maura L Gillison Journal: J Clin Oncol Date: 2011-10-03 Impact factor: 44.544
Authors: Jeremy D Meier; Hongtao Xie; Yang Sun; Yinghua Sun; Nisa Hatami; Brian Poirier; Laura Marcu; D Gregory Farwell Journal: Otolaryngol Head Neck Surg Date: 2010-06 Impact factor: 3.497
Authors: Siyu Shi; Ravi Vissapragada; Joseph Abi Jaoude; Caroline Huang; Anmol Mittal; Elisa Liu; Jim Zhong; Vivek Kumar Journal: Bioact Mater Date: 2020-02-21
Authors: Alexandra Iulia Irimie; Laura Sonea; Ancuta Jurj; Nikolay Mehterov; Alina Andreea Zimta; Liviuta Budisan; Cornelia Braicu; Ioana Berindan-Neagoe Journal: Int J Nanomedicine Date: 2017-06-26
Authors: Betina Børresen; Anders Elias Hansen; Frederikke Petrine Fliedner; Jonas Rosager Henriksen; Dennis Ringkjøbing Elema; Malene Brandt-Larsen; Lotte Kellemann Kristensen; Annemarie Thuri Kristensen; Thomas Lars Andresen; Andreas Kjær Journal: Int J Nanomedicine Date: 2020-11-02