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Literature DB >> 24012368

Chemical approaches to stem cell biology and therapeutics.

Wenlin Li¹, Ke Li, Wanguo Wei, Sheng Ding.

Abstract

Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of stem cells. Rational design and screening for small molecules have identified useful compounds to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and have facilitated the development of cell-based therapies and therapeutic drugs targeting endogenous stem and progenitor cells for repair and regeneration. Here, we will discuss recent scientific and therapeutic progress, as well as new perspectives and future challenges for using chemical approaches in stem cell biology and regenerative medicine.

Entities: CellLine Chemical Disease Gene Species

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Year: 2013 PMID： 24012368 PMCID： PMC3898630 DOI： 10.1016/j.stem.2013.08.002

Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633

115 in total

1. Direct reprogramming of fibroblasts into neural stem cells by defined factors.

Authors: Dong Wook Han; Natalia Tapia; Andreas Hermann; Kathrin Hemmer; Susanne Höing; Marcos J Araúzo-Bravo; Holm Zaehres; Guangming Wu; Stefan Frank; Sören Moritz; Boris Greber; Ji Hun Yang; Hoon Taek Lee; Jens C Schwamborn; Alexander Storch; Hans R Schöler
Journal: Cell Stem Cell Date: 2012-03-22 Impact factor: 24.633

2. Efficient derivation of functional floor plate tissue from human embryonic stem cells.

Authors: Christopher A Fasano; Stuart M Chambers; Gabsang Lee; Mark J Tomishima; Lorenz Studer
Journal: Cell Stem Cell Date: 2010-04-02 Impact factor: 24.633

3. A chemical platform for improved induction of human iPSCs.

Authors: Tongxiang Lin; Rajesh Ambasudhan; Xu Yuan; Wenlin Li; Simon Hilcove; Ramzey Abujarour; Xiangyi Lin; Heung Sik Hahm; Ergeng Hao; Alberto Hayek; Sheng Ding
Journal: Nat Methods Date: 2009-10-18 Impact factor: 28.547

4. Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.

Authors: Wenlin Li; HongYan Zhou; Ramzey Abujarour; Saiyong Zhu; Jin Young Joo; Tongxiang Lin; Ergeng Hao; Hans R Schöler; Alberto Hayek; Sheng Ding
Journal: Stem Cells Date: 2009-12 Impact factor: 6.277

5. BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells.

Authors: Pablo Ramirez; Michael P Rettig; Geoffrey L Uy; Elena Deych; Matthew S Holt; Julie K Ritchey; John F DiPersio
Journal: Blood Date: 2009-07-01 Impact factor: 22.113

6. The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.

Authors: Jian-Chien Dominic Heng; Bo Feng; Jianyong Han; Jianming Jiang; Petra Kraus; Jia-Hui Ng; Yuriy L Orlov; Mikael Huss; Lin Yang; Thomas Lufkin; Bing Lim; Huck-Hui Ng
Journal: Cell Stem Cell Date: 2010-01-21 Impact factor: 24.633

7. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

Authors: Justin K Ichida; Joel Blanchard; Kelvin Lam; Esther Y Son; Julia E Chung; Dieter Egli; Kyle M Loh; Ava C Carter; Francesco P Di Giorgio; Kathryn Koszka; Danwei Huangfu; Hidenori Akutsu; David R Liu; Lee L Rubin; Kevin Eggan
Journal: Cell Stem Cell Date: 2009-10-08 Impact factor: 24.633

8. GSK-3 is a master regulator of neural progenitor homeostasis.

Authors: Woo-Yang Kim; Xinshuo Wang; Yaohong Wu; Bradley W Doble; Satish Patel; James R Woodgett; William D Snider
Journal: Nat Neurosci Date: 2009-10-04 Impact factor: 24.884

9. Chromatin-modifying enzymes as modulators of reprogramming.

Authors: Tamer T Onder; Nergis Kara; Anne Cherry; Amit U Sinha; Nan Zhu; Kathrin M Bernt; Patrick Cahan; B Ogan Marcarci; Juli Unternaehrer; Piyush B Gupta; Eric S Lander; Scott A Armstrong; George Q Daley
Journal: Nature Date: 2012-03-04 Impact factor: 49.962

10. Direct conversion of fibroblasts to functional neurons by defined factors.

Authors: Thomas Vierbuchen; Austin Ostermeier; Zhiping P Pang; Yuko Kokubu; Thomas C Südhof; Marius Wernig
Journal: Nature Date: 2010-01-27 Impact factor: 49.962

74 in total

Review 1. New approaches for direct conversion of patient fibroblasts into neural cells.

Authors: Suhasni Gopalakrishnan; Pooja Hor; Justin K Ichida
Journal: Brain Res Date: 2015-10-16 Impact factor: 3.252

2. The future of iPS cells in advancing regenerative medicine.

Authors: Peng Liu; K E Li; Shaohua Xu
Journal: Genet Res (Camb) Date: 2016-02-11 Impact factor: 1.588

3. Improved Proliferative Capacity of NP-Like Cells Derived from Human Mesenchymal Stromal Cells and Neuronal Transdifferentiation by Small Molecules.

Authors: Alejandro Aguilera-Castrejon; Herminia Pasantes-Morales; Juan José Montesinos; Lorena V Cortés-Medina; Marta E Castro-Manrreza; Héctor Mayani; Gerardo Ramos-Mandujano
Journal: Neurochem Res Date: 2016-11-02 Impact factor: 3.996

4. Translational strategies and challenges in regenerative medicine.

Authors: Stefanie Dimmeler; Sheng Ding; Thomas A Rando; Alan Trounson
Journal: Nat Med Date: 2014-08 Impact factor: 53.440

5. Emerging innovation towards safety in the clinical application of ESCs and iPSCs.

Authors: Shigeo Masuda; Shigeru Miyagawa; Satsuki Fukushima; Nagako Sougawa; Emiko Ito; Maki Takeda; Atsuhiro Saito; Yoshiki Sawa
Journal: Nat Rev Cardiol Date: 2014-08-05 Impact factor: 32.419

6. Sensitizing ovarian cancer cells to chemotherapy by interfering with pathways that are involved in the formation of cancer stem cells.

Authors: Kamola Saydaminova; Robert Strauss; Min Xie; Jiri Bartek; Maximilian Richter; Ruan van Rensburg; Charles Drescher; Anja Ehrhardt; Sheng Ding; André Lieber
Journal: Cancer Biol Ther Date: 2016-08-30 Impact factor: 4.742