Literature DB >> 19838168

A chemical platform for improved induction of human iPSCs.

Tongxiang Lin1, Rajesh Ambasudhan, Xu Yuan, Wenlin Li, Simon Hilcove, Ramzey Abujarour, Xiangyi Lin, Heung Sik Hahm, Ergeng Hao, Alberto Hayek, Sheng Ding.   

Abstract

The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.

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Year:  2009        PMID： 19838168      PMCID： PMC3724527          DOI： 10.1038/nmeth.1393

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  15 in total

1.  A combined chemical and genetic approach for the generation of induced pluripotent stem cells.

Authors:  Yan Shi; Jeong Tae Do; Caroline Desponts; Heung Sik Hahm; Hans R Schöler; Sheng Ding
Journal:  Cell Stem Cell       Date:  2008-06-05       Impact factor: 24.633

Review 2.  A chemical approach to stem-cell biology and regenerative medicine.

Authors:  Yue Xu; Yan Shi; Sheng Ding
Journal:  Nature       Date:  2008-05-15       Impact factor: 49.962

Review 3.  An overview of epithelio-mesenchymal transformation.

Authors:  E D Hay
Journal:  Acta Anat (Basel)       Date:  1995

4.  The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells.

Authors:  Yu-Fen Chou; Hsu-Hsin Chen; Maureen Eijpe; Akiko Yabuuchi; Joshua G Chenoweth; Paul Tesar; Jun Lu; Ronald D G McKay; Niels Geijsen
Journal:  Cell       Date:  2008-10-31       Impact factor: 41.582

5.  Induced pluripotent stem cell lines derived from human somatic cells.

Authors:  Junying Yu; Maxim A Vodyanik; Kim Smuga-Otto; Jessica Antosiewicz-Bourget; Jennifer L Frane; Shulan Tian; Jeff Nie; Gudrun A Jonsdottir; Victor Ruotti; Ron Stewart; Igor I Slukvin; James A Thomson
Journal:  Science       Date:  2007-11-20       Impact factor: 47.728

6.  Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Authors:  Kazutoshi Takahashi; Koji Tanabe; Mari Ohnuki; Megumi Narita; Tomoko Ichisaka; Kiichiro Tomoda; Shinya Yamanaka
Journal:  Cell       Date:  2007-11-30       Impact factor: 41.582

7.  Reversine increases the plasticity of lineage-committed mammalian cells.

Authors:  Shuibing Chen; Shinichi Takanashi; Qisheng Zhang; Wen Xiong; Shoutian Zhu; Eric C Peters; Sheng Ding; Peter G Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-12       Impact factor: 11.205

8.  Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.

Authors:  Danwei Huangfu; Kenji Osafune; René Maehr; Wenjun Guo; Astrid Eijkelenboom; Shuibing Chen; Whitney Muhlestein; Douglas A Melton
Journal:  Nat Biotechnol       Date:  2008-10-12       Impact factor: 54.908

Review 9.  TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease.

Authors:  Brigham C Willis; Zea Borok
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2007-07-13       Impact factor: 5.464

Review 10.  Upping the ante: recent advances in direct reprogramming.

Authors:  Lars U W Müller; George Q Daley; David A Williams
Journal:  Mol Ther       Date:  2009-03-31       Impact factor: 11.454
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  233 in total

1.  Intermediate filament protein accumulation in motor neurons derived from giant axonal neuropathy iPSCs rescued by restoration of gigaxonin.

Authors:  Bethany L Johnson-Kerner; Faizzan S Ahmad; Alejandro Garcia Diaz; John Palmer Greene; Steven J Gray; Richard Jude Samulski; Wendy K Chung; Rudy Van Coster; Paul Maertens; Scott A Noggle; Christopher E Henderson; Hynek Wichterle
Journal:  Hum Mol Genet       Date:  2014-11-04       Impact factor: 6.150

Review 2.  Induced pluripotent stem cells--opportunities for disease modelling and drug discovery.

Authors:  Marica Grskovic; Ashkan Javaherian; Berta Strulovici; George Q Daley
Journal:  Nat Rev Drug Discov       Date:  2011-11-11       Impact factor: 84.694

Review 3.  Regenerative chemical biology: current challenges and future potential.

Authors:  Ada Ao; Jijun Hao; Charles C Hong
Journal:  Chem Biol       Date:  2011-04-22

Review 4.  Using human pluripotent stem cells to untangle neurodegenerative disease mechanisms.

Authors:  Brigitte Malgrange; Laurence Borgs; Benjamin Grobarczyk; Audrey Purnelle; Patricia Ernst; Gustave Moonen; Laurent Nguyen
Journal:  Cell Mol Life Sci       Date:  2010-10-26       Impact factor: 9.261

Review 5.  Smooth muscle and other cell sources for human blood vessel engineering.

Authors:  Sumati Sundaram; Laura E Niklason
Journal:  Cells Tissues Organs       Date:  2011-10-25       Impact factor: 2.481

6.  Induced pluripotent stem cell clones reprogrammed via recombinant adeno-associated virus-mediated transduction contain integrated vector sequences.

Authors:  J Weltner; A Anisimov; K Alitalo; T Otonkoski; R Trokovic
Journal:  J Virol       Date:  2012-02-01       Impact factor: 5.103

7.  Human amniotic mesenchymal stem cell-derived induced pluripotent stem cells may generate a universal source of cardiac cells.

Authors:  Xiaohu Ge; I-Ning E Wang; Ildiko Toma; Vittorio Sebastiano; Jianwei Liu; Manish J Butte; Renee A Reijo Pera; Phillip C Yang
Journal:  Stem Cells Dev       Date:  2012-06-11       Impact factor: 3.272

8.  Small molecules enable highly efficient neuronal conversion of human fibroblasts.

Authors:  Julia Ladewig; Jerome Mertens; Jaideep Kesavan; Jonas Doerr; Daniel Poppe; Finnja Glaue; Stefan Herms; Peter Wernet; Gesine Kögler; Franz-Josef Müller; Philipp Koch; Oliver Brüstle
Journal:  Nat Methods       Date:  2012-04-08       Impact factor: 28.547

Review 9.  Cellular reprogramming: a new technology frontier in pharmaceutical research.

Authors:  Amy Brock; Hui-Tong Goh; Binxia Yang; Yu Lu; Hu Li; Yuin-Han Loh
Journal:  Pharm Res       Date:  2011-11-09       Impact factor: 4.200

10.  Sensitizing ovarian cancer cells to chemotherapy by interfering with pathways that are involved in the formation of cancer stem cells.

Authors:  Kamola Saydaminova; Robert Strauss; Min Xie; Jiri Bartek; Maximilian Richter; Ruan van Rensburg; Charles Drescher; Anja Ehrhardt; Sheng Ding; André Lieber
Journal:  Cancer Biol Ther       Date:  2016-08-30       Impact factor: 4.742
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