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Literature DB >> 26864234

The future of iPS cells in advancing regenerative medicine.

Abstract

Induced pluripotent stem (iPS) cells have great potential in regenerative medicine, including cell replacement therapies and disease modelling in vitro. However, with this potential comes several challenges, including clinical safety, reprogramming and differentiation efficiency, and compromised functionality of differentiated cell types after transplantation. Many of these issues arise from imprecise control of cell fate. With large-scale sequencing and genome-editing technologies we can now precisely manipulate the genome, which has expanded our knowledge of functional cell types and cell identity. These technologies may improve our efforts in generating iPS-derived therapeutic cells and in development of therapies for human diseases.

Entities: Chemical Species

Mesh：

Year: 2016 PMID： 26864234 PMCID： PMC6865139 DOI： 10.1017/S001667231600001X

Source DB: PubMed Journal: Genet Res (Camb) ISSN： 0016-6723 Impact factor: 1.588

48 in total

Review 1. Potential pitfalls of CRISPR/Cas9-mediated genome editing.

Authors: Rongxue Peng; Guigao Lin; Jinming Li
Journal: FEBS J Date: 2015-11-27 Impact factor: 5.542

2. Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants.

Authors: Stephen C J Parker; Michael L Stitzel; D Leland Taylor; Jose Miguel Orozco; Michael R Erdos; Jennifer A Akiyama; Kelly Lammerts van Bueren; Peter S Chines; Narisu Narisu; Brian L Black; Axel Visel; Len A Pennacchio; Francis S Collins
Journal: Proc Natl Acad Sci U S A Date: 2013-10-14 Impact factor: 11.205

3. Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells.

Authors: Zaida Alipio; Wenbin Liao; Elizabeth J Roemer; Milton Waner; Louis M Fink; David C Ward; Yupo Ma
Journal: Proc Natl Acad Sci U S A Date: 2010-07-07 Impact factor: 11.205

4. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors: Kazutoshi Takahashi; Shinya Yamanaka
Journal: Cell Date: 2006-08-10 Impact factor: 41.582

5. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.

Authors: Silvana Konermann; Mark D Brigham; Alexandro E Trevino; Julia Joung; Omar O Abudayyeh; Clea Barcena; Patrick D Hsu; Naomi Habib; Jonathan S Gootenberg; Hiroshi Nishimasu; Osamu Nureki; Feng Zhang
Journal: Nature Date: 2014-12-10 Impact factor: 49.962

6. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.

Authors: Angel Raya; Ignasi Rodríguez-Pizà; Guillermo Guenechea; Rita Vassena; Susana Navarro; María José Barrero; Antonella Consiglio; Maria Castellà; Paula Río; Eduard Sleep; Federico González; Gustavo Tiscornia; Elena Garreta; Trond Aasen; Anna Veiga; Inder M Verma; Jordi Surrallés; Juan Bueren; Juan Carlos Izpisúa Belmonte
Journal: Nature Date: 2009-05-31 Impact factor: 49.962

7. Highly efficient Cas9-mediated transcriptional programming.

Authors: Alejandro Chavez; Jonathan Scheiman; Suhani Vora; Benjamin W Pruitt; Marcelle Tuttle; Eswar P R Iyer; Shuailiang Lin; Samira Kiani; Christopher D Guzman; Daniel J Wiegand; Dmitry Ter-Ovanesyan; Jonathan L Braff; Noah Davidsohn; Benjamin E Housden; Norbert Perrimon; Ron Weiss; John Aach; James J Collins; George M Church
Journal: Nat Methods Date: 2015-03-02 Impact factor: 28.547

8. In vivo genome editing using Staphylococcus aureus Cas9.

Authors: F Ann Ran; Le Cong; Winston X Yan; David A Scott; Jonathan S Gootenberg; Andrea J Kriz; Bernd Zetsche; Ophir Shalem; Xuebing Wu; Kira S Makarova; Eugene V Koonin; Phillip A Sharp; Feng Zhang
Journal: Nature Date: 2015-04-01 Impact factor: 49.962

The future of iPS cells in advancing regenerative medicine.

Review 1. Potential pitfalls of CRISPR/Cas9-mediated genome editing.

2. Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants.

3. Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic beta-like cells.

4. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

5. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.

6. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells.

7. Highly efficient Cas9-mediated transcriptional programming.

8. In vivo genome editing using Staphylococcus aureus Cas9.

9. Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus.

10. CRISPR RNA-guided activation of endogenous human genes.

Review 1. iPSCs: A powerful tool for skeletal muscle tissue engineering.

Review 2. In Vitro Generated Hepatocyte-Like Cells: A Novel Tool in Regenerative Medicine and Drug Discovery.