Literature DB >> 2400398

Chromogenic depsipeptide substrates for beta-lactamases and penicillin-sensitive DD-peptidases.

M Adam1, C Damblon, B Plaitin, L Christiaens, J M Frère.   

Abstract

Various ester and thioester derivatives of hippuric acid have been prepared which were substrates of both beta-lactamases and DD-peptidases. The thioesters were more rapidly hydrolysed by nearly all the enzymes. Surprisingly, the enzymes acted rather efficiently on substrates which did not contain any chiral centre.

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Year:  1990        PMID： 2400398      PMCID： PMC1131754          DOI： 10.1042/bj2700525

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

1.  Exocellular DD-carboxypeptidases-transpeptidases from Streptomyces.

Authors:  J M Frére; M Leyh-Bouille; J M Ghuysen; M Nieto; H R Perkins
Journal:  Methods Enzymol       Date:  1976       Impact factor: 1.600

2.  The diversity of the catalytic properties of class A beta-lactamases.

Authors:  A Matagne; A M Misselyn-Bauduin; B Joris; T Erpicum; B Granier; J M Frère
Journal:  Biochem J       Date:  1990-01-01       Impact factor: 3.857

3.  Nuclear analogues of beta-lactam antibiotics. 2 The total synthesis of 8-oxo-4-thia-z-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acids.

Authors:  D B Byran; R F Hall; K G Holden; W F Huffman; J G Gleason
Journal:  J Am Chem Soc       Date:  1977-03-30       Impact factor: 15.419

4.  Automated analysis of enzyme inactivation phenomena. Application to beta-lactamases and DD-peptidases.

Authors:  F De Meester; B Joris; G Reckinger; C Bellefroid-Bourguignon; J M Frère; S G Waley
Journal:  Biochem Pharmacol       Date:  1987-07-15       Impact factor: 5.858

5.  Molecular weight and amino acid composition of the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61.

Authors:  J M Frère; J M Ghuysen; H R Perkins; M Nieto
Journal:  Biochem J       Date:  1973-11       Impact factor: 3.857

6.  The exocellular DD-carboxypeptidase-endopeptidase from Streptomyces albus G. Purification and chemical properties.

Authors:  C Duez; J M Frère; F Geurts; J M Ghuysen; L Dierickx; L Delcambe
Journal:  Biochem J       Date:  1978-12-01       Impact factor: 3.857

7.  Kinetics and mechanism of the serine beta-lactamase catalyzed hydrolysis of depsipeptides.

Authors:  C P Govardhan; R F Pratt
Journal:  Biochemistry       Date:  1987-06-16       Impact factor: 3.162

8.  Molecular weight, amino acid composition and physicochemical properties of the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39.

Authors:  J M Frère; R Moreno; J M Ghuysen
Journal:  Biochem J       Date:  1974-10       Impact factor: 3.857

9.  Interactions of cephalosporins with the Streptomyces R61 DD-transpeptidase/carboxypeptidase. Influence of the 3'-substituent.

Authors:  W S Faraci; R F Pratt
Journal:  Biochem J       Date:  1986-08-15       Impact factor: 3.857
  9 in total
  39 in total

1.  Importance of the two tryptophan residues in the Streptomyces R61 exocellular DD-peptidase.

Authors:  C Bourguignon-Bellefroid; J M Wilkin; B Joris; R T Aplin; C Houssier; F G Prendergast; J Van Beeumen; J M Ghuysen; J M Frère
Journal:  Biochem J       Date:  1992-03-01       Impact factor: 3.857

2.  The bimodular G57-V577 polypeptide chain of the class B penicillin-binding protein 3 of Escherichia coli catalyzes peptide bond formation from thiolesters and does not catalyze glycan chain polymerization from the lipid II intermediate.

Authors:  M Adam; C Fraipont; N Rhazi; M Nguyen-Distèche; B Lakaye; J M Frère; B Devreese; J Van Beeumen; Y van Heijenoort; J van Heijenoort; J M Ghuysen
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

3.  The mutation Lys234His yields a class A beta-lactamase with a novel pH-dependence.

Authors:  J Brannigan; A Matagne; F Jacob; C Damblon; B Joris; D Klein; B G Spratt; J M Frère
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857

4.  Accumulation of acyl-enzyme in DD-peptidase-catalysed reactions with analogues of peptide substrates.

Authors:  M Jamin; M Adam; C Damblon; L Christiaens; J M Frère
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

5.  Acyltransferase activities of the high-molecular-mass essential penicillin-binding proteins.

Authors:  M Adam; C Damblon; M Jamin; W Zorzi; V Dusart; M Galleni; A el Kharroubi; G Piras; B G Spratt; W Keck
Journal:  Biochem J       Date:  1991-10-15       Impact factor: 3.857

6.  The mechanism of action of DD-peptidases: the role of tyrosine-159 in the Streptomyces R61 DD-peptidase.

Authors:  J M Wilkin; M Jamin; C Damblon; G H Zhao; B Joris; C Duez; J M Frère
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857

7.  Importance of the His-298 residue in the catalytic mechanism of the Streptomyces R61 extracellular DD-peptidase.

Authors:  A M Hadonou; M Jamin; M Adam; B Joris; J Dusart; J M Ghuysen; J M Frère
Journal:  Biochem J       Date:  1992-03-01       Impact factor: 3.857

8.  Reaction of soluble penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus with beta-lactams and acyclic substrates: kinetics in homogeneous solution.

Authors:  K Graves-Woodward; R F Pratt
Journal:  Biochem J       Date:  1998-06-15       Impact factor: 3.857

9.  Altered peptidoglycan composition in vancomycin-resistant Enterococcus faecalis.

Authors:  B L de Jonge; S Handwerger; D Gage
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

10.  Mechanism of action of DD-peptidases: role of asparagine-161 in the Streptomyces R61 DD-peptidase.

Authors:  J M Wilkin; M Jamin; B Joris; J M Frere
Journal:  Biochem J       Date:  1993-07-01       Impact factor: 3.857
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