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Literature DB >> 23999438

Oncometabolites: linking altered metabolism with cancer.

Ming Yang¹, Tomoyoshi Soga, Patrick J Pollard.

Abstract

The discovery of cancer-associated mutations in genes encoding key metabolic enzymes has provided a direct link between altered metabolism and cancer. Advances in mass spectrometry and nuclear magnetic resonance technologies have facilitated high-resolution metabolite profiling of cells and tumors and identified the accumulation of metabolites associated with specific gene defects. Here we review the potential roles of such "oncometabolites" in tumor evolution and as clinical biomarkers for the detection of cancers characterized by metabolic dysregulation.

Entities: Chemical

Mesh：

Substances：

Year: 2013 PMID： 23999438 PMCID： PMC3754247 DOI： 10.1172/JCI67228

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

116 in total

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Journal: Cold Spring Harb Symp Quant Biol Date: 2011-11-16

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Journal: Oncologist Date: 2011-12-16 Impact factor: 5.837

7. Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.

Authors: Zachary J Reitman; Genglin Jin; Edward D Karoly; Ivan Spasojevic; Jian Yang; Kenneth W Kinzler; Yiping He; Darell D Bigner; Bert Vogelstein; Hai Yan
Journal: Proc Natl Acad Sci U S A Date: 2011-02-02 Impact factor: 12.779

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10. Comprehensive genomic characterization of squamous cell lung cancers.

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158 in total

1. Exploiting tumor metabolism: challenges for clinical translation.

Authors: Matthew G Vander Heiden
Journal: J Clin Invest Date: 2013-09-03 Impact factor: 14.808

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Authors: Thomas D Niehaus; Jacob Folz; Donald R McCarty; Arthur J L Cooper; David Moraga Amador; Oliver Fiehn; Andrew D Hanson
Journal: J Biol Chem Date: 2018-04-06 Impact factor: 5.157

3. Gene expression analysis in peripheral blood cells of patients with hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC): identification of NRF2 pathway activation.

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Journal: Fam Cancer Date: 2018-10 Impact factor: 2.375

4. Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity.

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Journal: Chem Biol Date: 2014-06-19

Review 5. The small members of the JMJD protein family: Enzymatic jewels or jinxes?

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Journal: Biochim Biophys Acta Rev Cancer Date: 2019-04-26 Impact factor: 10.680

6. TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2α as a therapeutic target.

Authors: Lin-Yu Chen; Rui-Lan Huang; Michael Wy Chan; Pearlly S Yan; Tien-Shuo Huang; Ren-Chin Wu; Yohan Suryo Rahmanto; Po-Hsuan Su; Yu-Chun Weng; Jian-Liang Chou; Tai-Kuang Chao; Yu-Chi Wang; Ie-Ming Shih; Hung-Cheng Lai
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