Literature DB >> 23998809

LongevityMap: a database of human genetic variants associated with longevity.

Arie Budovsky1, Thomas Craig, Jingwei Wang, Robi Tacutu, Attila Csordas, Joana Lourenço, Vadim E Fraifeld, João Pedro de Magalhães.   

Abstract

Understanding the genetic basis of human longevity remains a challenge but could lead to life-extending interventions and better treatments for age-related diseases. Toward this end we developed the LongevityMap (http://genomics.senescence.info/longevity/), the first database of genes, loci, and variants studied in the context of human longevity and healthy ageing. We describe here its content and interface, and discuss how it can help to unravel the genetics of human longevity.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GWAS; ageing; genetics; humans; lifespan; polymorphisms

Mesh：

Year:  2013        PMID： 23998809     DOI： 10.1016/j.tig.2013.08.003

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  28 in total

1.  In silico approaches and the role of ontologies in aging research.

Authors:  Georg Fuellen; Melanie Boerries; Hauke Busch; Aubrey de Grey; Udo Hahn; Thomas Hiller; Andreas Hoeflich; Ludger Jansen; Georges E Janssens; Christoph Kaleta; Anne C Meinema; Sascha Schäuble; Andreas Simm; Paul N Schofield; Barry Smith; Juergen Sühnel; Julio Vera; Wolfgang Wagner; Eva C Wönne; Daniel Wuttke
Journal:  Rejuvenation Res       Date:  2013-12       Impact factor: 4.663

2.  Polycomb repressive complex 2 epigenomic signature defines age-associated hypermethylation and gene expression changes.

Authors:  Mikhail G Dozmorov
Journal:  Epigenetics       Date:  2015-04-16       Impact factor: 4.528

3.  SMAD Transcription Factor, Sma-9, Attunes TGF-β Signaling Cascade Towards Modulating Amyloid Beta Aggregation and Associated Outcome in Transgenic C. elegans.

Authors:  Rizwanul Haque; Aamir Nazir
Journal:  Mol Neurobiol       Date:  2014-11-19       Impact factor: 5.590

4.  FOXO3 and Exceptional Longevity: Insights From Hydra to Humans.

Authors:  Philip M C Davy; Richard C Allsopp; Timothy A Donlon; Brian J Morris; Donald Craig Willcox; Bradley J Willcox
Journal:  Curr Top Dev Biol       Date:  2018       Impact factor: 4.897

5.  Whole genome sequences of 2 octogenarians with sustained cognitive abilities.

Authors:  Dorothee Nickles; Lohith Madireddy; Nihar Patel; Noriko Isobe; Bruce L Miller; Sergio E Baranzini; Joel H Kramer; Jorge R Oksenberg
Journal:  Neurobiol Aging       Date:  2014-12-16       Impact factor: 4.673

6.  Predicting age by mining electronic medical records with deep learning characterizes differences between chronological and physiological age.

Authors:  Zichen Wang; Li Li; Benjamin S Glicksberg; Ariel Israel; Joel T Dudley; Avi Ma'ayan
Journal:  J Biomed Inform       Date:  2017-11-04       Impact factor: 6.317

7.  The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan.

Authors:  Dario Riccardo Valenzano; Bérénice A Benayoun; Param Priya Singh; Elisa Zhang; Paul D Etter; Chi-Kuo Hu; Mathieu Clément-Ziza; David Willemsen; Rongfeng Cui; Itamar Harel; Ben E Machado; Muh-Ching Yee; Sabrina C Sharp; Carlos D Bustamante; Andreas Beyer; Eric A Johnson; Anne Brunet
Journal:  Cell       Date:  2015-12-03       Impact factor: 41.582

Review 8.  Parkinson's disease as a result of aging.

Authors:  Manuel Rodriguez; Clara Rodriguez-Sabate; Ingrid Morales; Alberto Sanchez; Magdalena Sabate
Journal:  Aging Cell       Date:  2015-02-09       Impact factor: 9.304

9.  Non-coding genomic regions possessing enhancer and silencer potential are associated with healthy aging and exceptional survival.

Authors:  Sangkyu Kim; David A Welsh; Leann Myers; Katie E Cherry; Jennifer Wyckoff; S Michal Jazwinski
Journal:  Oncotarget       Date:  2015-02-28

Review 10.  Omics in a Digital World: The Role of Bioinformatics in Providing New Insights Into Human Aging.

Authors:  Serena Dato; Paolina Crocco; Nicola Rambaldi Migliore; Francesco Lescai
Journal:  Front Genet       Date:  2021-06-10       Impact factor: 4.599
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