Literature DB >> 23984440

Activating silent argonautes.

Mary Anne Kidwell, Jennifer A Doudna.   

Abstract

Multiple Argonaute proteins are implicated in gene silencing by RNA interference (RNAi), but only one is known to be an endonuclease that can cleave target mRNAs. Chimeric Argonaute proteins now reveal an unexpected mechanism by which mutations distal to the catalytic center can unmask intrinsic catalytic activity, results hinting at structurally mediated regulation.

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Year:  2013        PMID： 23984440     DOI： 10.1038/nsmb.2620

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  14 in total

1.  Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes.

Authors:  Shintaro Iwasaki; Maki Kobayashi; Mayuko Yoda; Yuriko Sakaguchi; Susumu Katsuma; Tsutomu Suzuki; Yukihide Tomari
Journal:  Mol Cell       Date:  2010-06-03       Impact factor: 17.970

2.  In vitro assembly of plant RNA-induced silencing complexes facilitated by molecular chaperone HSP90.

Authors:  Taichiro Iki; Manabu Yoshikawa; Masaki Nishikiori; Mauren C Jaudal; Eiko Matsumoto-Yokoyama; Ichiro Mitsuhara; Tetsuo Meshi; Masayuki Ishikawa
Journal:  Mol Cell       Date:  2010-06-03       Impact factor: 17.970

3.  Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects.

Authors:  Sebastian Petri; Anne Dueck; Gerhard Lehmann; Nicholas Putz; Sabine Rüdel; Elisabeth Kremmer; Gunter Meister
Journal:  RNA       Date:  2011-03-02       Impact factor: 4.942

4.  DNA shuffling of a family of genes from diverse species accelerates directed evolution.

Authors:  A Crameri; S A Raillard; E Bermudez; W P Stemmer
Journal:  Nature       Date:  1998-01-15       Impact factor: 49.962

Review 5.  Molecular mechanisms of RNA interference.

Authors:  Ross C Wilson; Jennifer A Doudna
Journal:  Annu Rev Biophys       Date:  2013       Impact factor: 12.981

6.  Molecular dissection of human Argonaute proteins by DNA shuffling.

Authors:  Nina Schürmann; Leonardo G Trabuco; Christian Bender; Robert B Russell; Dirk Grimm
Journal:  Nat Struct Mol Biol       Date:  2013-06-09       Impact factor: 15.369

7.  The structure of human argonaute-2 in complex with miR-20a.

Authors:  Elad Elkayam; Claus-D Kuhn; Ante Tocilj; Astrid D Haase; Emily M Greene; Gregory J Hannon; Leemor Joshua-Tor
Journal:  Cell       Date:  2012-06-07       Impact factor: 41.582

8.  Structure of yeast Argonaute with guide RNA.

Authors:  Kotaro Nakanishi; David E Weinberg; David P Bartel; Dinshaw J Patel
Journal:  Nature       Date:  2012-06-20       Impact factor: 49.962

9.  Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.

Authors:  Yanli Wang; Stefan Juranek; Haitao Li; Gang Sheng; Greg S Wardle; Thomas Tuschl; Dinshaw J Patel
Journal:  Nature       Date:  2009-10-08       Impact factor: 49.962

10.  Regulation of Argonaute slicer activity by guide RNA 3' end interactions with the N-terminal lobe.

Authors:  Junho K Hur; Michelle K Zinchenko; Sergej Djuranovic; Rachel Green
Journal:  J Biol Chem       Date:  2013-01-17       Impact factor: 5.157
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  1 in total

1.  KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182.

Authors:  Nishi R Sharma; Vladimir Majerciak; Michael J Kruhlak; Lulu Yu; Jeong Gu Kang; Acong Yang; Shuo Gu; Marvin J Fritzler; Zhi-Ming Zheng
Journal:  Nucleic Acids Res       Date:  2019-09-26       Impact factor: 16.971
  1 in total

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