Literature DB >> 23975139

DMSO enhances electrospray response, boosting sensitivity of proteomic experiments.

Hannes Hahne1, Fiona Pachl, Benjamin Ruprecht, Stefan K Maier, Susan Klaeger, Dominic Helm, Guillaume Médard, Matthias Wilm, Simone Lemeer, Bernhard Kuster.   

Abstract

We report that low percentages of dimethylsulfoxide (DMSO) in liquid chromatography solvents lead to a strong enhancement of electrospray ionization of peptides, improving the sensitivity of protein identification in bottom-up proteomics by up to tenfold. The method can be easily implemented on any LC-MS/MS system without modification to hardware or software and at no additional cost.

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Year:  2013        PMID： 23975139     DOI： 10.1038/nmeth.2610

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  17 in total

1.  Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics.

Authors:  Juri Rappsilber; Yasushi Ishihama; Matthias Mann
Journal:  Anal Chem       Date:  2003-02-01       Impact factor: 6.986

Review 2.  Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present.

Authors:  Marcus Bantscheff; Simone Lemeer; Mikhail M Savitski; Bernhard Kuster
Journal:  Anal Bioanal Chem       Date:  2012-07-08       Impact factor: 4.142

Review 3.  Proteomics: a pragmatic perspective.

Authors:  Parag Mallick; Bernhard Kuster
Journal:  Nat Biotechnol       Date:  2010-07-09       Impact factor: 54.908

4.  Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap.

Authors:  Jesper V Olsen; Lyris M F de Godoy; Guoqing Li; Boris Macek; Peter Mortensen; Reinhold Pesch; Alexander Makarov; Oliver Lange; Stevan Horning; Matthias Mann
Journal:  Mol Cell Proteomics       Date:  2005-10-24       Impact factor: 5.911

5.  Capillary-based multi nanoelectrospray emitters: improvements in ion transmission efficiency and implementation with capillary reversed-phase LC-ESI-MS.

Authors:  Ryan T Kelly; Jason S Page; Rui Zhao; Wei-Jun Qian; Heather M Mottaz; Keqi Tang; Richard D Smith
Journal:  Anal Chem       Date:  2007-11-29       Impact factor: 6.986

6.  MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification.

Authors:  Jürgen Cox; Matthias Mann
Journal:  Nat Biotechnol       Date:  2008-11-30       Impact factor: 54.908

7.  Andromeda: a peptide search engine integrated into the MaxQuant environment.

Authors:  Jürgen Cox; Nadin Neuhauser; Annette Michalski; Richard A Scheltema; Jesper V Olsen; Matthias Mann
Journal:  J Proteome Res       Date:  2011-02-22       Impact factor: 4.466

8.  Analytical properties of the nanoelectrospray ion source.

Authors:  M Wilm; M Mann
Journal:  Anal Chem       Date:  1996-01-01       Impact factor: 6.986

9.  Mechanism of charging and supercharging molecules in electrospray ionization.

Authors:  Anthony T Iavarone; Evan R Williams
Journal:  J Am Chem Soc       Date:  2003-02-26       Impact factor: 15.419

10.  The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry.

Authors:  Judit Villén; Steven P Gygi
Journal:  Nat Protoc       Date:  2008       Impact factor: 13.491
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  56 in total

1.  Comprehensive and reproducible phosphopeptide enrichment using iron immobilized metal ion affinity chromatography (Fe-IMAC) columns.

Authors:  Benjamin Ruprecht; Heiner Koch; Guillaume Medard; Max Mundt; Bernhard Kuster; Simone Lemeer
Journal:  Mol Cell Proteomics       Date:  2014-11-13       Impact factor: 5.911

2.  Quantification of Dynamic Protein Interactions and Phosphorylation in LPS Signaling Pathway by SWATH-MS.

Authors:  Xiurong Wu; Daowei Yang; Fu Zhao; Zhang-Hua Yang; Dazheng Wang; Muzhen Qiao; Yuan Fang; Wanyun Li; Rui Wu; Peng He; Yu Cong; Chang'an Chen; Lichen Hu; Yihua Yan; Changchuan Xie; Yaying Wu; Jiahuai Han; Chuan-Qi Zhong
Journal:  Mol Cell Proteomics       Date:  2019-03-08       Impact factor: 5.911

3.  Bacterial Cellulose Shifts Transcriptome and Proteome of Cultured Endothelial Cells Towards Native Differentiation.

Authors:  Gerhard Feil; Ralf Horres; Julia Schulte; Andreas F Mack; Svenja Petzoldt; Caroline Arnold; Chen Meng; Lukas Jost; Jochen Boxleitner; Nicole Kiessling-Wolf; Ender Serbest; Dominic Helm; Bernhard Kuster; Isabel Hartmann; Thomas Korff; Hannes Hahne
Journal:  Mol Cell Proteomics       Date:  2017-06-21       Impact factor: 5.911

4.  Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells.

Authors:  Hayami Sugiyama; Kazutoshi Takahashi; Takuya Yamamoto; Mio Iwasaki; Megumi Narita; Masahiro Nakamura; Tim A Rand; Masato Nakagawa; Akira Watanabe; Shinya Yamanaka
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-21       Impact factor: 11.205

5.  ProteomeTools: Systematic Characterization of 21 Post-translational Protein Modifications by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Using Synthetic Peptides.

Authors:  Daniel Paul Zolg; Mathias Wilhelm; Tobias Schmidt; Guillaume Médard; Johannes Zerweck; Tobias Knaute; Holger Wenschuh; Ulf Reimer; Karsten Schnatbaum; Bernhard Kuster
Journal:  Mol Cell Proteomics       Date:  2018-05-29       Impact factor: 5.911

6.  DMSO Assisted Electrospray Ionization for the Detection of Small Peptide Hormones in Urine by Dilute-and-Shoot-Liquid-Chromatography-High Resolution Mass Spectrometry.

Authors:  Péter Judák; Janelle Grainger; Catrin Goebel; Peter Van Eenoo; Koen Deventer
Journal:  J Am Soc Mass Spectrom       Date:  2017-04-19       Impact factor: 3.109

7.  Integrated Cellular and Plasma Proteomics of Contrasting B-cell Cancers Reveals Common, Unique and Systemic Signatures.

Authors:  Harvey E Johnston; Matthew J Carter; Kerry L Cox; Melanie Dunscombe; Antigoni Manousopoulou; Paul A Townsend; Spiros D Garbis; Mark S Cragg
Journal:  Mol Cell Proteomics       Date:  2017-01-04       Impact factor: 5.911

8.  Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics.

Authors:  Dominic Helm; Johannes P C Vissers; Christopher J Hughes; Hannes Hahne; Benjamin Ruprecht; Fiona Pachl; Arkadiusz Grzyb; Keith Richardson; Jason Wildgoose; Stefan K Maier; Harald Marx; Mathias Wilhelm; Isabelle Becher; Simone Lemeer; Marcus Bantscheff; James I Langridge; Bernhard Kuster
Journal:  Mol Cell Proteomics       Date:  2014-08-08       Impact factor: 5.911

9.  Meltome atlas-thermal proteome stability across the tree of life.

Authors:  Anna Jarzab; Nils Kurzawa; Thomas Hopf; Matthias Moerch; Jana Zecha; Niels Leijten; Yangyang Bian; Eva Musiol; Melanie Maschberger; Gabriele Stoehr; Isabelle Becher; Charlotte Daly; Patroklos Samaras; Julia Mergner; Britta Spanier; Angel Angelov; Thilo Werner; Marcus Bantscheff; Mathias Wilhelm; Martin Klingenspor; Simone Lemeer; Wolfgang Liebl; Hannes Hahne; Mikhail M Savitski; Bernhard Kuster
Journal:  Nat Methods       Date:  2020-04-13       Impact factor: 28.547

10.  Enhancing Sensitivity of Liquid Chromatography-Mass Spectrometry of Peptides and Proteins Using Supercharging Agents.

Authors:  Michael Nshanian; Rajeswari Lakshmanan; Hao Chen; Rachel R Ogorzalek Loo; Joseph A Loo
Journal:  Int J Mass Spectrom       Date:  2017-12-24       Impact factor: 1.986
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