Donghui Zhou1, Yuanzhe Jin2, Fengchen Yao1, Zhiying Duan1, Qi Wang1, Jing Liu1. 1. Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China. 2. Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China. Electronic address: yuanzhe_jin@126.com.
Abstract
BACKGROUND: Numerous studies have investigated the association between adiponectin +45 nucleotide T/G (+45T>G) polymorphisms and cardiovascular disease (CVD). However, these studies have been inconclusive because of obvious inconsistencies among results. The present study aims to quantify the strength of the association between +45T>G (rs2241766) in the adiponectin gene and the risk of CVD. METHODS: We searched the PubMed, Embase, and Wangfang databases for studies related to the association between the adiponectin +45T>G genotype and the risk of CVD. We estimated the summary odds ratio (OR) with 95% confidence interval (CI) to assess the association. RESULTS: A total of 28 case-control studies, with 12,378 CVD cases and 19,368 controls, were included in the meta-analysis. The meta-analysis of the 28 studies showed that the single-nucleotide polymorphism (SNP) +45T>G genotype was associated with an increased risk of CVD (random-effects OR = 1.22, 95% CI 1.08-1.39, p = 0.002). After adjusting for heterogeneity, the meta-analysis showed that the SNP +45T>G genotype was associated with the risk of CVD in the analyses of the total population and the Caucasian population (for the total population, fixed-effects OR = 1.11, 95% CI 1.01-1.23, p = 0.012; for the Caucasian population, fixed-effects OR = 1.16, 95% CI 1.01-1.34, p = 0.039). No significant association was found in other populations. Evidence of publication bias was observed in the meta-analysis. CONCLUSION: A significant association between rs2241766 in the adiponectin gene and CVD was established by the meta-analysis.
BACKGROUND: Numerous studies have investigated the association between adiponectin +45 nucleotide T/G (+45T>G) polymorphisms and cardiovascular disease (CVD). However, these studies have been inconclusive because of obvious inconsistencies among results. The present study aims to quantify the strength of the association between +45T>G (rs2241766) in the adiponectin gene and the risk of CVD. METHODS: We searched the PubMed, Embase, and Wangfang databases for studies related to the association between the adiponectin +45T>G genotype and the risk of CVD. We estimated the summary odds ratio (OR) with 95% confidence interval (CI) to assess the association. RESULTS: A total of 28 case-control studies, with 12,378 CVD cases and 19,368 controls, were included in the meta-analysis. The meta-analysis of the 28 studies showed that the single-nucleotide polymorphism (SNP) +45T>G genotype was associated with an increased risk of CVD (random-effects OR = 1.22, 95% CI 1.08-1.39, p = 0.002). After adjusting for heterogeneity, the meta-analysis showed that the SNP +45T>G genotype was associated with the risk of CVD in the analyses of the total population and the Caucasian population (for the total population, fixed-effects OR = 1.11, 95% CI 1.01-1.23, p = 0.012; for the Caucasian population, fixed-effects OR = 1.16, 95% CI 1.01-1.34, p = 0.039). No significant association was found in other populations. Evidence of publication bias was observed in the meta-analysis. CONCLUSION: A significant association between rs2241766 in the adiponectin gene and CVD was established by the meta-analysis.
Authors: Joseph Sam Kanu; Shuang Qiu; Yi Cheng; Ri Li; Changgui Kou; Yulu Gu; Ye Bai; Jikang Shi; Yong Li; Yunkai Liu; Yaqin Yu; Yawen Liu Journal: Lipids Health Dis Date: 2018-05-28 Impact factor: 3.876