PURPOSE: To discuss the association between adiponectin (ADIPOQ) gene rs2241766 and rs1501299 polymorphisms and the risk of colorectal cancer, and to analyze the role of the interaction between these two loci and environmental factors in colorectal cancer pathogenesis. METHODS: The case-control study was performed with a 1:1 match. A self-designed questionnaire was used to perform a face-to-face survey with 600 new primary colorectal cancer cases confirmed by histopathology as well as 600 cases of people receiving a physical examination at the same time. The general information, lifestyle, and diet habits, etc. were collected from two groups of study subjects. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to identify ADIPOQ rs2241766 and rs1501299 genotypes. RESULTS: After adjusting for factors such as colorectal cancer family history, body-mass index (BMI), daily sedentary time, weekly red meat intake frequency, as well regular tea drinking, conditional logistic regression analysis indicated that rs2241766 TG+GG carriers had a higher risk of colorectal cancer than TT carriers (OR=1.433, 95% CI: 1.014-1.985); rs1501299 GT+TT carriers had a lower risk of colorectal cancer than GG carriers (OR=0.723, 95% CI: 0.531-0.902). Generalized multifactor dimensionality reduction analysis showed that ADIPOQ rs2241766 and rs1501299 could have interaction with red meat intake (p=0.001). CONCLUSION: ADIPOQ rs2241766 and rs1501299 single nucleotide polymorphisms (SNPs) could be associated with colorectal pathogenesis and could have interactions with red meat intake. Both factors impact colorectal cancer occurrence.
PURPOSE: To discuss the association between adiponectin (ADIPOQ) gene rs2241766 and rs1501299 polymorphisms and the risk of colorectal cancer, and to analyze the role of the interaction between these two loci and environmental factors in colorectal cancer pathogenesis. METHODS: The case-control study was performed with a 1:1 match. A self-designed questionnaire was used to perform a face-to-face survey with 600 new primary colorectal cancer cases confirmed by histopathology as well as 600 cases of people receiving a physical examination at the same time. The general information, lifestyle, and diet habits, etc. were collected from two groups of study subjects. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to identify ADIPOQrs2241766 and rs1501299 genotypes. RESULTS: After adjusting for factors such as colorectal cancer family history, body-mass index (BMI), daily sedentary time, weekly red meat intake frequency, as well regular tea drinking, conditional logistic regression analysis indicated that rs2241766 TG+GG carriers had a higher risk of colorectal cancer than TT carriers (OR=1.433, 95% CI: 1.014-1.985); rs1501299 GT+TT carriers had a lower risk of colorectal cancer than GG carriers (OR=0.723, 95% CI: 0.531-0.902). Generalized multifactor dimensionality reduction analysis showed that ADIPOQrs2241766 and rs1501299 could have interaction with red meat intake (p=0.001). CONCLUSION:ADIPOQrs2241766 and rs1501299 single nucleotide polymorphisms (SNPs) could be associated with colorectal pathogenesis and could have interactions with red meat intake. Both factors impact colorectal cancer occurrence.
Authors: Marije Oostindjer; Jan Alexander; Gro V Amdam; Grethe Andersen; Nathan S Bryan; Duan Chen; Denis E Corpet; Stefaan De Smet; Lars Ove Dragsted; Anna Haug; Anders H Karlsson; Gijs Kleter; Theo M de Kok; Bård Kulseng; Andrew L Milkowski; Roy J Martin; Anne-Maria Pajari; Jan Erik Paulsen; Jana Pickova; Knut Rudi; Marianne Sødring; Douglas L Weed; Bjørg Egelandsdal Journal: Meat Sci Date: 2014-02-24 Impact factor: 5.209
Authors: Sylvia H Ley; Qi Sun; Walter C Willett; A Heather Eliassen; Kana Wu; An Pan; Fran Grodstein; Frank B Hu Journal: Am J Clin Nutr Date: 2013-11-27 Impact factor: 7.045
Authors: Paulette D Chandler; Julie E Buring; JoAnn E Manson; M V Moorthy; Shumin Zhang; I-Min Lee; Jennifer H Lin Journal: Cancer Causes Control Date: 2015-05-05 Impact factor: 2.506
Authors: Kelsey A Chun; Jonathan M Kocarnik; Sheetal S Hardikar; Jamaica R Robinson; Sonja I Berndt; Andrew T Chan; Jane C Figueiredo; Noralane M Lindor; Mingyang Song; Robert E Schoen; Richard B Hayes; John D Potter; Rami Nassir; Stéphane Bézieau; Loic Le Marchand; Martha L Slattery; Emily White; Ulrike Peters; Polly A Newcomb Journal: PLoS One Date: 2018-10-31 Impact factor: 3.240