Literature DB >> 23971528

Which immune cells matter? The immunopathogenesis of multiple sclerosis.

Bieke Broux1, Piet Stinissen, Niels Hellings.   

Abstract

Multiple sclerosis (MS) is a complex disease of the central nervous system (CNS), which is believed to be immune-mediated. While CD4+ T cells have been the main suspects for years, there is ample evidence that other immune cells (including those of the innate immune system) play a contributing or regulating role in this disease. After a general introduction, this review focuses on different immune cell subsets implicated in MS pathogenesis and on current and future possibilities to target them for therapeutic use.

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Year:  2013        PMID： 23971528     DOI： 10.1615/critrevimmunol.2013007453

Source DB:  PubMed          Journal:  Crit Rev Immunol        ISSN： 1040-8401            Impact factor:   2.214


  13 in total

Review 1.  Glial regulation of the blood-brain barrier in health and disease.

Authors:  Bieke Broux; Elizabeth Gowing; Alexandre Prat
Journal:  Semin Immunopathol       Date:  2015-08-06       Impact factor: 9.623

2.  Serum levels of histamine and diamine oxidase in multiple sclerosis.

Authors:  Aryan Rafiee Zadeh; Masih Falahatian; Fereshteh Alsahebfosoul
Journal:  Am J Clin Exp Immunol       Date:  2018-12-20

3.  Differential upregulation of the hypothetical transmembrane protein 66 (TMEM66) in multiple sclerosis patients with potential inflammatory response.

Authors:  Safa Taha; Muna Aljishi; Isa Alsharoqi; Moiz Bakhiet
Journal:  Biomed Rep       Date:  2014-11-17

4.  Compositional changes of B and T cell subtypes during fingolimod treatment in multiple sclerosis patients: a 12-month follow-up study.

Authors:  Nele Claes; Tessa Dhaeze; Judith Fraussen; Bieke Broux; Bart Van Wijmeersch; Piet Stinissen; Raymond Hupperts; Niels Hellings; Veerle Somers
Journal:  PLoS One       Date:  2014-10-31       Impact factor: 3.240

5.  Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis.

Authors:  Steffan D Bos; Christian M Page; Bettina K Andreassen; Emon Elboudwarej; Marte W Gustavsen; Farren Briggs; Hong Quach; Ingvild S Leikfoss; Anja Bjølgerud; Tone Berge; Hanne F Harbo; Lisa F Barcellos
Journal:  PLoS One       Date:  2015-03-03       Impact factor: 3.240

Review 6.  Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases.

Authors:  Valerio Chiurchiù; Antonio Orlacchio; Mauro Maccarrone
Journal:  Oxid Med Cell Longev       Date:  2015-12-31       Impact factor: 6.543

7.  Genome-wide DNA methylation profiling of CD8+ T cells shows a distinct epigenetic signature to CD4+ T cells in multiple sclerosis patients.

Authors:  Vicki E Maltby; Moira C Graves; Rodney A Lea; Miles C Benton; Katherine A Sanders; Lotti Tajouri; Rodney J Scott; Jeannette Lechner-Scott
Journal:  Clin Epigenetics       Date:  2015-11-05       Impact factor: 6.551

Review 8.  B Cells Are Multifunctional Players in Multiple Sclerosis Pathogenesis: Insights from Therapeutic Interventions.

Authors:  Nele Claes; Judith Fraussen; Piet Stinissen; Raymond Hupperts; Veerle Somers
Journal:  Front Immunol       Date:  2015-12-21       Impact factor: 7.561

9.  Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells.

Authors:  Katherine A Sanders; Miles C Benton; Rod A Lea; Vicki E Maltby; Susan Agland; Nathan Griffin; Rodney J Scott; Lotti Tajouri; Jeannette Lechner-Scott
Journal:  Clin Epigenetics       Date:  2016-08-27       Impact factor: 6.551

10.  Cytotoxic CD4+ T Cells Drive Multiple Sclerosis Progression.

Authors:  Liesbet M Peeters; Marjan Vanheusden; Veerle Somers; Bart Van Wijmeersch; Piet Stinissen; Bieke Broux; Niels Hellings
Journal:  Front Immunol       Date:  2017-09-20       Impact factor: 7.561
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