Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Glial regulation of the blood-brain barrier in health and disease.

Literature DB >> 26245144

Glial regulation of the blood-brain barrier in health and disease.

Bieke Broux^1,2,3, Elizabeth Gowing^1,2, Alexandre Prat^4,5.

Abstract

The brain is the organ with the highest metabolic demand in the body. Therefore, it needs specialized vasculature to provide it with the necessary oxygen and nutrients, while protecting it against pathogens and toxins. The blood-brain barrier (BBB) is very tightly regulated by specialized endothelial cells, two basement membranes, and astrocytic endfeet. The proximity of astrocytes to the vessel makes them perfect candidates to influence the function of the BBB. Moreover, other glial cells are also known to contribute to either BBB quiescence or breakdown. In this review, we summarize the knowledge on glial regulation of the BBB during development, in homeostatic conditions in the adult, and during neuroinflammatory responses.

Entities: Chemical

Keywords: Astrocytes; Blood-brain barrier; Central nervous system; Development; Endothelial cells; Microglia; Multiple sclerosis; Neuroinflammation

Mesh：

Year: 2015 PMID： 26245144 DOI： 10.1007/s00281-015-0516-2

Source DB: PubMed Journal: Semin Immunopathol ISSN： 1863-2297 Impact factor: 9.623

174 in total

Review 1. Disruption of central nervous system barriers in multiple sclerosis.

Authors: Jorge Ivan Alvarez; Romain Cayrol; Alexandre Prat
Journal: Biochim Biophys Acta Date: 2010-07-07

2. Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter.

Authors: Praveen Ballabh; Furong Hu; Mithun Kumarasiri; Alex Braun; Maiken Nedergaard
Journal: Pediatr Res Date: 2005-10 Impact factor: 3.756

3. Death receptors DR6 and TROY regulate brain vascular development.

Authors: Stephen J Tam; David L Richmond; Joshua S Kaminker; Zora Modrusan; Baby Martin-McNulty; Tim C Cao; Robby M Weimer; Richard A D Carano; Nick van Bruggen; Ryan J Watts
Journal: Dev Cell Date: 2012-02-14 Impact factor: 12.270

4. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate.

Authors: J D Rothstein; M Dykes-Hoberg; C A Pardo; L A Bristol; L Jin; R W Kuncl; Y Kanai; M A Hediger; Y Wang; J P Schielke; D F Welty
Journal: Neuron Date: 1996-03 Impact factor: 17.173

5. Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown.

Authors: Dennis Yeung; Janet L Manias; Duncan J Stewart; Sukriti Nag
Journal: Acta Neuropathol Date: 2008-03-21 Impact factor: 17.088

6. Blood-brain barrier impairment in Alzheimer disease: stability and functional significance.

Authors: G L Bowman; J A Kaye; M Moore; D Waichunas; N E Carlson; J F Quinn
Journal: Neurology Date: 2007-05-22 Impact factor: 9.910

7. Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation.

Authors: Jeroen F J Bogie; Piet Stinissen; Niels Hellings; Jerome J A Hendriks
Journal: J Neuroinflammation Date: 2011-07-25 Impact factor: 8.322

Review 8. Immune privilege as an intrinsic CNS property: astrocytes protect the CNS against T-cell-mediated neuroinflammation.

Authors: Ulrike Gimsa; N Avrion Mitchison; Monika C Brunner-Weinzierl
Journal: Mediators Inflamm Date: 2013-08-20 Impact factor: 4.711

9. Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation.

Authors: Mark R Kotter; Wen-Wu Li; Chao Zhao; Robin J M Franklin
Journal: J Neurosci Date: 2006-01-04 Impact factor: 6.167

10. Resolution of central nervous system astrocytic and endothelial sources of CCL2 gene expression during evolving neuroinflammation.

Authors: Bandana Shrestha; Shujun Ge; Joel S Pachter
Journal: Fluids Barriers CNS Date: 2014-03-04

16 in total

Review 1. Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain.

Authors: Marijke De Bock; Luc Leybaert; Christian Giaume
Journal: Neurochem Res Date: 2017-06-20 Impact factor: 3.996

Review 2. Microglia: Housekeeper of the Central Nervous System.

Authors: John Alimamy Kabba; Yazhou Xu; Handson Christian; Wenchen Ruan; Kitchen Chenai; Yun Xiang; Luyong Zhang; Juan M Saavedra; Tao Pang
Journal: Cell Mol Neurobiol Date: 2017-05-22 Impact factor: 5.046

3. A transcriptome-based assessment of the astrocytic dystrophin-associated complex in the developing human brain.

Authors: Matthew J Simon; Charles Murchison; Jeffrey J Iliff
Journal: J Neurosci Res Date: 2017-05-16 Impact factor: 4.164

4. Inactivation of Hedgehog signal transduction in adult astrocytes results in region-specific blood-brain barrier defects.

Authors: Hui Wang; Zhiyan Xu; Ziyue Xia; Michael Rallo; Andrew Duffy; Michael P Matise
Journal: Proc Natl Acad Sci U S A Date: 2021-08-24 Impact factor: 11.205

5. Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity.

Authors: Doryssa Hermans; Evelien Houben; Niels Hellings; Bieke Broux; Paulien Baeten; Helena Slaets; Kris Janssens; Cindy Hoeks; Baharak Hosseinkhani; Gayel Duran; Seppe Bormans; Elizabeth Gowing; Chloé Hoornaert; Lien Beckers; Wing Ka Fung; Horst Schroten; Hiroshi Ishikawa; Judith Fraussen; Ronald Thoelen; Helga E de Vries; Gijs Kooij; Stephanie Zandee; Alexandre Prat
Journal: Acta Neuropathol Date: 2022-06-06 Impact factor: 15.887