BACKGROUND: The relation between histopathologic subclassification and mode of patient presentation (with a screen-detected vs. symptomatic lesion) with an abnormality in the breast core biopsy classified as having uncertain malignant potential (B3) has not been previously examined. We compared the histopathologic subclassification of these lesions and the frequency of malignancy in screen-detected and symptomatic patient groups. METHODS: All B3 core biopsies from one breast unit at the Royal Berkshire Hospital over a 5-year period (2006-2010) were analyzed (n = 131). After dividing the B3 biopsies into screen-detected and symptomatic groups, the National Health Service Breast Screening Programme histopathologic subclassification was used to further divide the groups into six subtypes. After surgery, a final diagnosis of invasive or in situ carcinoma was also noted. RESULTS: B3 classification comprised 3.8 % (131/3,440) of all core biopsies during that time period. There were 78 specimens from symptomatic (59 %) and 53 from screen-detected (41 %) patients. There was no statistically significant difference between papillary and fibroepithelial diagnoses between the two groups (47 vs. 42 %, p = 0.59, NS). There was no difference between the groups for atypia, lobular neoplasia, or sclerosing lesions (49 vs. 51 %, p = 0.8, NS). Cancer was found in 20 % of the symptomatic patients and in 17 % of the screen-detected group (p = 0.65, NS). CONCLUSIONS: Mode of patient presentation (with a screen-detected or symptomatic lesion) was not a distinguishing factor for breast histopathologic subclassification or for the final cancer diagnosis in patients whose breast core biopsy was classified as B3.
BACKGROUND: The relation between histopathologic subclassification and mode of patient presentation (with a screen-detected vs. symptomatic lesion) with an abnormality in the breast core biopsy classified as having uncertain malignant potential (B3) has not been previously examined. We compared the histopathologic subclassification of these lesions and the frequency of malignancy in screen-detected and symptomatic patient groups. METHODS: All B3 core biopsies from one breast unit at the Royal Berkshire Hospital over a 5-year period (2006-2010) were analyzed (n = 131). After dividing the B3 biopsies into screen-detected and symptomatic groups, the National Health Service Breast Screening Programme histopathologic subclassification was used to further divide the groups into six subtypes. After surgery, a final diagnosis of invasive or in situ carcinoma was also noted. RESULTS: B3 classification comprised 3.8 % (131/3,440) of all core biopsies during that time period. There were 78 specimens from symptomatic (59 %) and 53 from screen-detected (41 %) patients. There was no statistically significant difference between papillary and fibroepithelial diagnoses between the two groups (47 vs. 42 %, p = 0.59, NS). There was no difference between the groups for atypia, lobular neoplasia, or sclerosing lesions (49 vs. 51 %, p = 0.8, NS). Cancer was found in 20 % of the symptomatic patients and in 17 % of the screen-detected group (p = 0.65, NS). CONCLUSIONS: Mode of patient presentation (with a screen-detected or symptomatic lesion) was not a distinguishing factor for breast histopathologic subclassification or for the final cancer diagnosis in patients whose breast core biopsy was classified as B3.
Authors: S Bianchi; S Caini; G Renne; E Cassano; D Ambrogetti; M G Cattani; G Saguatti; M Chiaramondia; E Bellotti; R Bottiglieri; A Ancona; Q Piubello; S Montemezzi; G Ficarra; C Mauri; F A Zito; V Ventrella; P Baccini; M Calabrese; D Palli Journal: Breast Date: 2011-01-03 Impact factor: 4.380
Authors: Karen A Lee; Margarita L Zuley; Mamatha Chivukula; Neha Desai Choksi; Marie A Ganott; Jules H Sumkin Journal: AJR Am J Roentgenol Date: 2012-02 Impact factor: 3.959
Authors: Daniel Shouhed; Farin F Amersi; Ryan Spurrier; Catherine Dang; Kristine Astvatsaturyan; Shika Bose; Edward Phillips Journal: Am Surg Date: 2012-10 Impact factor: 0.688
Authors: Emad A Rakha; Andrew H S Lee; Jacquie A Jenkins; Alison E Murphy; Lisa J Hamilton; Ian O Ellis Journal: Int J Cancer Date: 2011-02-11 Impact factor: 7.396