Literature DB >> 23954288

Excision of 8-oxoguanine from methylated CpG dinucleotides by human 8-oxoguanine DNA glycosylase.

Rustem D Kasymov1, Inga R Grin, Anton V Endutkin, Serge L Smirnov, Alexander A Ishchenko, Murat K Saparbaev, Dmitry O Zharkov.   

Abstract

CpG dinucleotides are targets for epigenetic methylation, many of them bearing 5-methylcytosine (mCyt) in the human genome. Guanine in this context can be easily oxidized to 8-oxoguanine (oxoGua), which is repaired by 8-oxoguanine-DNA glycosylase (OGG1). We have studied how methylation affects the efficiency of oxoGua excision from damaged CpG dinucleotides. Methylation of the adjacent cytosine moderately decreased the oxoGua excision rate while methylation opposite oxoGua lowered the rate of product release. Cytosine methylation abolished stimulation of OGG1 by repair endonuclease APEX1. The OGG1 S326C polymorphic variant associated with lung cancer showed poorer base excision and lost sensitivity to the opposite-base methylation. The overall repair in the system reconstituted from purified proteins decreased for CpG with mCyt in the damaged strand.
Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  5-Methylcytosine; 8-Oxoguanine; DNA repair; Epigenetic methylation; OGG1

Mesh：

Substances：

Year:  2013        PMID： 23954288     DOI： 10.1016/j.febslet.2013.08.008

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β.

Authors:  Michael J Howard; K Grace Foley; David D Shock; Vinod K Batra; Samuel H Wilson
Journal:  J Biol Chem       Date:  2019-03-18       Impact factor: 5.157

2.  Inactivation of a common OGG1 variant by TNF-alpha in mammalian cells.

Authors:  Jordan Morreall; Kristin Limpose; Clayton Sheppard; Yoke Wah Kow; Erica Werner; Paul W Doetsch
Journal:  DNA Repair (Amst)       Date:  2014-12-04

3.  OGG1 contributes to hepatocellular carcinoma by promoting cell cycle-related protein expression and enhancing DNA oxidative damage repair in tumor cells.

Authors:  He Zhang; Peng-Jun Jiang; Meng-Yuan Lv; Yan-Hua Zhao; Ju Cui; Jie Chen
Journal:  J Clin Lab Anal       Date:  2022-06-19       Impact factor: 3.124

4.  Oxidative damage to epigenetically methylated sites affects DNA stability, dynamics and enzymatic demethylation.

Authors:  David R Gruber; Joanna J Toner; Heather L Miears; Andrey V Shernyukov; Alexey S Kiryutin; Alexander A Lomzov; Anton V Endutkin; Inga R Grin; Darya V Petrova; Maxim S Kupryushkin; Alexandra V Yurkovskaya; Eric C Johnson; Mark Okon; Elena G Bagryanskaya; Dmitry O Zharkov; Serge L Smirnov
Journal:  Nucleic Acids Res       Date:  2018-11-16       Impact factor: 16.971

5.  Base excision repair of tandem modifications in a methylated CpG dinucleotide.

Authors:  Akira Sassa; Melike Çağlayan; Nadezhda S Dyrkheeva; William A Beard; Samuel H Wilson
Journal:  J Biol Chem       Date:  2014-04-02       Impact factor: 5.157

Review 6.  An active alternative splicing isoform of human mitochondrial 8-oxoguanine DNA glycosylase (OGG1).

Authors:  Chie Furihata
Journal:  Genes Environ       Date:  2015-10-01

7.  Molecular Mechanisms Associated with Clustered Lesion-Induced Impairment of 8-oxoG Recognition by the Human Glycosylase OGG1.

Authors:  Tao Jiang; Antonio Monari; Elise Dumont; Emmanuelle Bignon
Journal:  Molecules       Date:  2021-10-26       Impact factor: 4.411
  7 in total

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