Literature DB >> 23943527

Hip dysplasia is more severe in Charcot-Marie-Tooth disease than in developmental dysplasia of the hip.

Eduardo N Novais1, Sara D Bixby, John Rennick, Patrick M Carry, Young-Jo Kim, Michael B Millis.   

Abstract

BACKGROUND: Patients with Charcot-Marie-Tooth disease may develop hip dysplasia. Hip geometry in these patients has not been well described in the literature. QUESTIONS/PURPOSES: We compared the hip morphometry in Charcot-Marie-Tooth hip dysplasia (CMTHD) and developmental dysplasia of the hip (DDH) in terms of extent of (1) acetabular dysplasia and subluxation, (2) acetabular anteversion and osseous support, (3) coxa valga and femoral version, and (4) osteoarthritis.
METHODS: Fourteen patients with CMTHD (19 hips; mean age, 23 years) presenting for periacetabular osteotomy were matched to 45 patients with DDH (45 hips; mean age, 21 years) based on age, sex, and BMI. We assessed acetabular dysplasia and subluxation using lateral center-edge angle (LCEA), anterior center-edge angle (ACEA), and acetabular roof angle of Tönnis (TA) on plain pelvic radiographs and acetabular volume, area of femoral head covered by acetabulum, and percentage of femoral head covered by acetabulum on three-dimensional CT reconstruction models. Acetabular version and bony support, femoral version, and neck-shaft angle were measured on two-dimensional axial CT scans. Hip osteoarthritis was graded radiographically according to Tönnis criteria.
RESULTS: Acetabular dysplasia was more severe in CMTHD, as measured by smaller LCEA (p < 0.001), ACEA (p < 0.001), and acetabular volume (p = 0.0178) and larger TA (p = 0.025). Hip subluxation was more pronounced in CMTHD, as demonstrated by lower area of femoral head covered by acetabulum (p = 0.034) and percentage of femoral head covered by acetabulum (p = 0.007). CMTHD was associated with higher acetabular anteversion (p < 0.001), lower anterior (p < 0.001) and posterior (p = 0.072) osseous support, and more severe coxa valga (p < 0.001). More (p = 0.006) arthritic hips were found in CMTHD.
CONCLUSIONS: The extent of acetabular dysplasia, hip subluxation, acetabular anteversion, coxa valga, and hip osteoarthritis was more severe in CMTHD. These findings are important in choosing the appropriate surgical strategy for patients affected by CMTHD.

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Year:  2014        PMID: 23943527      PMCID: PMC3890158          DOI: 10.1007/s11999-013-3127-z

Source DB:  PubMed          Journal:  Clin Orthop Relat Res        ISSN: 0009-921X            Impact factor:   4.176


  43 in total

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2.  Developmental hip dysplasia in hereditary motor and sensory neuropathy type 1.

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Journal:  J Pediatr Orthop       Date:  1999 Jan-Feb       Impact factor: 2.324

3.  The predictive value of computed tomography in the treatment of developmental dysplasia of the hip.

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Journal:  J Pediatr Orthop       Date:  1998 Nov-Dec       Impact factor: 2.324

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5.  The periacetabular osteotomy. Minimum 2 year followup in more than 100 hips.

Authors:  S J Trumble; K A Mayo; J W Mast
Journal:  Clin Orthop Relat Res       Date:  1999-06       Impact factor: 4.176

6.  Computed tomography measurements of the acetabulum in adult dysplastic hips: which level is appropriate?

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Journal:  Skeletal Radiol       Date:  1991       Impact factor: 2.199

7.  Acetabular angles and femoral anteversion in dysplastic hips in adults: CT investigation.

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Journal:  J Comput Assist Tomogr       Date:  1991 Jan-Feb       Impact factor: 1.826

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Journal:  J Pediatr Orthop       Date:  1993 Jul-Aug       Impact factor: 2.324

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Journal:  Clin Orthop Relat Res       Date:  1989-10       Impact factor: 4.176

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3.  Which Acetabular Landmarks are the Most Useful for Measuring the Acetabular Index and Center-edge Angle in Developmental Dysplasia of the Hip? A Comparison of Two Methods.

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Review 4.  The genetics of Charcot-Marie-Tooth disease: current trends and future implications for diagnosis and management.

Authors:  J Chad Hoyle; Michael C Isfort; Jennifer Roggenbuck; W David Arnold
Journal:  Appl Clin Genet       Date:  2015-10-19

Review 5.  Novel methionyl-tRNA synthetase gene variants/phenotypes in interstitial lung and liver disease: A case report and review of literature.

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6.  Management of gait impairments in people with Charcot-Marie-Tooth disease: A treatment algorithm.

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