Literature DB >> 23941827

Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion.

Saravana R K Murthy1, Evan Dupart1, Najla Al-Sweel1, Alexander Chen1, Niamh X Cawley1, Y Peng Loh1.   

Abstract

Carboxypeptidase E (CPE), a prohormone processing enzyme is highly expressed and secreted from (neuro)endocrine tumors and gliomas, and has been implicated in cancer progression by promoting tumor growth. Our study demonstrates that secreted or exogenously applied CPE promotes survival of pheochromocytoma (PC12) and hepatocellular carcinoma (MHCC97H) cells under nutrient starvation and hypoxic conditions, but had no effect on their proliferation. CPE also reduced migration and invasion of fibrosarcoma (HT1080) cells. We show that CPE treatment mediates survival of MHCC97H cells during metabolic stress by up-regulating the expression of anti-apoptotic protein BCL-2, and other pro-survival genes, via activation of the ERK1/2 pathway. Published by Elsevier Ireland Ltd.

Entities:  

Keywords:  Cell invasion; Cell survival; Fibrosarcoma; Hepatocellular carcinoma; Pheochromocytoma

Mesh：

Substances：

Year:  2013        PMID： 23941827      PMCID： PMC3825807          DOI： 10.1016/j.canlet.2013.08.011

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


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