Literature DB >> 24691800

Carboxypeptidase E (NF-α1): a new trophic factor in neuroprotection.

Yong Cheng1, Niamh X Cawley, Y Peng Loh.   

Abstract

Carboxypeptidase E (CPE) is a prohormone-processing enzyme and sorting receptor that functions intracellularly. However, recent studies have demonstrated that CPE acts as a trophic factor extracellularly to up-regulate the expression of a pro-survival gene. This mini-review summarizes the roles of CPE in neuroprotection and the implications for neurodegenerative diseases.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24691800      PMCID： PMC4181327          DOI： 10.1007/s12264-013-1430-z

Source DB:  PubMed          Journal:  Neurosci Bull        ISSN： 1995-8218            Impact factor:   5.203


  32 in total

Review 1.  New roles of carboxypeptidase E in endocrine and neural function and cancer.

Authors:  Niamh X Cawley; William C Wetsel; Saravana R K Murthy; Joshua J Park; Karel Pacak; Y Peng Loh
Journal:  Endocr Rev       Date:  2012-03-07       Impact factor: 19.871

2.  Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons.

Authors:  Kuei-Cheng Lim; Carolyn M Tyler; Seung T Lim; Rita Giuliano; Howard J Federoff
Journal:  Biochem Biophys Res Commun       Date:  2007-07-20       Impact factor: 3.575

3.  Secretory sorting receptors carboxypeptidase E and secretogranin III in amyloid β-associated neural degeneration in Alzheimer's disease.

Authors:  Virginia Plá; Sonia Paco; Gregory Ghezali; Victor Ciria; Esther Pozas; Isidro Ferrer; Fernando Aguado
Journal:  Brain Pathol       Date:  2012-11-01       Impact factor: 6.508

4.  A carboxypeptidase processing enzyme for enkephalin precursors.

Authors:  V Y Hook; L E Eiden; M J Brownstein
Journal:  Nature       Date:  1982-01-28       Impact factor: 49.962

5.  Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e.

Authors:  Hong Lou; Soo-Kyung Kim; Eugene Zaitsev; Chris R Snell; Bai Lu; Y Peng Loh
Journal:  Neuron       Date:  2005-01-20       Impact factor: 17.173

Review 6.  Neuroprotective role for galanin in Alzheimer's disease.

Authors:  Scott E Counts; Sylvia E Perez; Stephen D Ginsberg; Elliott J Mufson
Journal:  Exp Suppl       Date:  2010

7.  The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits.

Authors:  Niamh X Cawley; Jiechun Zhou; Joanna M Hill; Daniel Abebe; Sylvie Romboz; Tulin Yanik; Ramona M Rodriguiz; William C Wetsel; Y Peng Loh
Journal:  Endocrinology       Date:  2004-09-09       Impact factor: 4.736

8.  Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication.

Authors:  An Zhou; Manabu Minami; Xiaoman Zhu; Sylvia Bae; John Minthorne; Jingquan Lan; Zhi-Gang Xiong; Roger P Simon
Journal:  J Cereb Blood Flow Metab       Date:  2004-06       Impact factor: 6.200

9.  Carboxypeptidase E promotes cancer cell survival, but inhibits migration and invasion.

Authors:  Saravana R K Murthy; Evan Dupart; Najla Al-Sweel; Alexander Chen; Niamh X Cawley; Y Peng Loh
Journal:  Cancer Lett       Date:  2013-08-11       Impact factor: 8.679

10.  The molecular profiles of neural stem cell niche in the adult subventricular zone.

Authors:  Cheol Lee; Jingqiong Hu; Sherry Ralls; Toshio Kitamura; Y Peng Loh; Yanqin Yang; Yoh-suke Mukouyama; Sohyun Ahn
Journal:  PLoS One       Date:  2012-11-29       Impact factor: 3.240
View more
  18 in total

1.  Cloning, gene regulation, and neuronal proliferation functions of novel N-terminal-truncated carboxypeptidase E/neurotrophic factor-αl variants in embryonic mouse brain.

Authors:  Lan Xiao; Xuyu Yang; Vinay Kumar Sharma; Y Peng Loh
Journal:  FASEB J       Date:  2018-07-31       Impact factor: 5.191

2.  N-terminal truncated carboxypeptidase E represses E-cadherin expression in lung cancer by stabilizing the Snail-HDAC complex.

Authors:  Jing Sun; Dawei Meng; Tao Yu; Feng Li; Guirong Zhang; Xin Tian; Nannan Zhao; Guimin Li; Lu Li; Hongyue Wang; Yeqiu Liu; Yiming Meng; Yushu Ma; Zhong Wan; Jimin Bao; Haozhe Piao
Journal:  Am J Cancer Res       Date:  2020-03-01       Impact factor: 6.166

3.  Neuroprotective effects of LMW and HMW FGF2 against amyloid beta toxicity in primary cultured hippocampal neurons.

Authors:  Yong Cheng; Zhaojin Li; Elissavet Kardami; Y Peng Loh
Journal:  Neurosci Lett       Date:  2016-08-18       Impact factor: 3.046

4.  Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a.

Authors:  N Skalka; M Caspi; L Lahav-Ariel; Y P Loh; K Hirschberg; R Rosin-Arbesfeld
Journal:  Oncogene       Date:  2016-07-04       Impact factor: 9.867

5.  Green Tea Polyphenols Attenuated Glutamate Excitotoxicity via Antioxidative and Antiapoptotic Pathway in the Primary Cultured Cortical Neurons.

Authors:  Lin Cong; Chang Cao; Yong Cheng; Xiao-Yan Qin
Journal:  Oxid Med Cell Longev       Date:  2015-12-15       Impact factor: 6.543

6.  carboxypeptidase E-ΔN, a neuroprotein transiently expressed during development protects embryonic neurons against glutamate neurotoxicity.

Authors:  Xiao-Yan Qin; Yong Cheng; Saravana R K Murthy; Prabhuanand Selvaraj; Y Peng Loh
Journal:  PLoS One       Date:  2014-11-26       Impact factor: 3.240

7.  A Novel Single Nucleotide T980C Polymorphism in the Human Carboxypeptidase E Gene Results in Loss of Neuroprotective Function.

Authors:  Lin Cong; Yong Cheng; Niamh X Cawley; Saravana R K Murthy; Y Peng Loh
Journal:  PLoS One       Date:  2017-01-23       Impact factor: 3.240

8.  Amyloid-β Impairs Vesicular Secretion in Neuronal and Astrocyte Peptidergic Transmission.

Authors:  Virginia Plá; Neus Barranco; Esther Pozas; Fernando Aguado
Journal:  Front Mol Neurosci       Date:  2017-06-28       Impact factor: 5.639

9.  A human carboxypeptidase E/NF-α1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice.

Authors:  Y Cheng; N X Cawley; T Yanik; S R K Murthy; C Liu; F Kasikci; D Abebe; Y P Loh
Journal:  Transl Psychiatry       Date:  2016-12-06       Impact factor: 6.222

Review 10.  Mechanisms and regulation of neurotrophin synthesis and secretion.

Authors:  Mohammad A Al-Qudah; Ahmed Al-Dwairi
Journal:  Neurosciences (Riyadh)       Date:  2016-10       Impact factor: 0.735
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.