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Literature DB >> 23935224

An efficient procedure for the preparation of natural products bearing the 2-(2-phenylethyl)chromone skeleton.

Dwight A Williams¹, Cameron Smith, Yan Zhang.

Abstract

Several 2-(2-phenylethyl)chromones have been shown to possess neuroprotective activity. However, limited synthetic methods have been disclosed to construct the 2-(2-phenylethyl)chromone skeleton. Herein we report a straightforward 3-step preparation of five naturally occurring 2-(2-phenylethyl)chromones utilizing the Claisen condensation as the key step.

Entities: Chemical Disease Species

Keywords: 2-(2-phenylethyl)chromones; Chromenes; Claisen condensation; Neuroprotection

Year: 2013 PMID： 23935224 PMCID： PMC3735228 DOI： 10.1016/j.tetlet.2013.06.006

Source DB: PubMed Journal: Tetrahedron Lett ISSN： 0040-4039 Impact factor: 2.415

11 in total

1. Preparative monohydroxyflavanone syntheses and a protocol for gas chromatography-mass spectrometry analysis of monohydroxyflavanones.

Authors: Hitoshi Kagawa; Asako Shigematsu; Shigeru Ohta; Yoshihiro Harigaya
Journal: Chem Pharm Bull (Tokyo) Date: 2005-05 Impact factor: 1.645

Review 2. Natural products to drugs: natural product derived compounds in clinical trials.

Authors: Mark S Butler
Journal: Nat Prod Rep Date: 2005-03-08 Impact factor: 13.423

Review 3. Natural products as sources of new drugs over the 30 years from 1981 to 2010.

Authors: David J Newman; Gordon M Cragg
Journal: J Nat Prod Date: 2012-02-08 Impact factor: 4.050

4. 2-(2-phenylethyl)chromones from Chinese eaglewood.

Authors: Lin Yang; Lirui Qiao; Dan Xie; Yuhe Yuan; Naihong Chen; Jungui Dai; Shunxing Guo
Journal: Phytochemistry Date: 2012-01-11 Impact factor: 4.072

Review 5. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.

Authors: E Middleton; C Kandaswami; T C Theoharides
Journal: Pharmacol Rev Date: 2000-12 Impact factor: 25.468

Review 6. Flavonoids: prospective drug candidates.

Authors: Luisa Helena Cazarolli; Leila Zanatta; Elga Heloisa Alberton; Maria Santos Reis Bonorino Figueiredo; Poliane Folador; Rosangela Guollo Damazio; Moacir Geraldo Pizzolatti; Fátima Regina Mena Barreto Silva
Journal: Mini Rev Med Chem Date: 2008-11 Impact factor: 3.862

An efficient procedure for the preparation of natural products bearing the 2-(2-phenylethyl)chromone skeleton.

1. Preparative monohydroxyflavanone syntheses and a protocol for gas chromatography-mass spectrometry analysis of monohydroxyflavanones.

Review 2. Natural products to drugs: natural product derived compounds in clinical trials.

Review 3. Natural products as sources of new drugs over the 30 years from 1981 to 2010.

4. 2-(2-phenylethyl)chromones from Chinese eaglewood.

Review 5. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.

Review 6. Flavonoids: prospective drug candidates.

7. Neuroprotective 2-(2-phenylethyl)chromones of Imperata cylindrica.

8. Structural basis for the activity of the RSK-specific inhibitor, SL0101.

9. 2-Substituted 4-(thio)chromenone 6-O-sulfamates: potent inhibitors of human steroid sulfatase.

10. The neuroprotective potential of flavonoids: a multiplicity of effects.

1. 5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.