Literature DB >> 18991758

Flavonoids: prospective drug candidates.

Luisa Helena Cazarolli1, Leila Zanatta, Elga Heloisa Alberton, Maria Santos Reis Bonorino Figueiredo, Poliane Folador, Rosangela Guollo Damazio, Moacir Geraldo Pizzolatti, Fátima Regina Mena Barreto Silva.   

Abstract

The purpose of this review is to discuss the recent developments related to the chemistry and medicinal properties of flavonoids. Major flavonoids that show well categorized structures and well defined structure function-relationships are: flavans, flavanones, flavones, flavanonols, flavonols, catechins, anthocyanidins and isoflavone. The biological properties of flavonoids include antioxidant, anti-inflamatory, antitumoral, antiviral and antibacterial, as well as a direct cytoprotective effect on coronary and vascular systems, the pancreas and the liver. These characteristics place them among the most attractive natural substances available to enrich the current therapy options.

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Year:  2008        PMID: 18991758     DOI: 10.2174/138955708786369564

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN: 1389-5575            Impact factor:   3.862


  55 in total

1.  Characterization of a glucosyltransferase enzyme involved in the formation of kaempferol and quercetin sophorosides in Crocus sativus.

Authors:  Almudena Trapero; Oussama Ahrazem; Angela Rubio-Moraga; Maria Luisa Jimeno; Maria Dolores Gómez; Lourdes Gómez-Gómez
Journal:  Plant Physiol       Date:  2012-05-30       Impact factor: 8.340

2.  Antagonism of human formyl peptide receptor 1 (FPR1) by chromones and related isoflavones.

Authors:  Igor A Schepetkin; Liliya N Kirpotina; Andrei I Khlebnikov; Ni Cheng; Richard D Ye; Mark T Quinn
Journal:  Biochem Pharmacol       Date:  2014-10-17       Impact factor: 5.858

3.  Asymmetric Methods for the Synthesis of Flavanones, Chromanones, and Azaflavanones.

Authors:  Antoinette E Nibbs; Karl A Scheidt
Journal:  European J Org Chem       Date:  2011-12-09

4.  High concentrations of a urinary biomarker of polyphenol intake are associated with decreased mortality in older adults.

Authors:  Raul Zamora-Ros; Montserrat Rabassa; Antonio Cherubini; Mireia Urpí-Sardà; Stefania Bandinelli; Luigi Ferrucci; Cristina Andres-Lacueva
Journal:  J Nutr       Date:  2013-06-26       Impact factor: 4.798

Review 5.  The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells.

Authors:  Eszter Baricza; Viola Tamási; Nikolett Marton; Edit I Buzás; György Nagy
Journal:  Cell Mol Life Sci       Date:  2015-10-28       Impact factor: 9.261

6.  Hesperedin promotes MyoD-induced myogenic differentiation in vitro and in vivo.

Authors:  Hana Jeong; Joo Yeon Lee; Eun Jung Jang; Eun Hye Lee; Myung Ae Bae; Jeong-Ho Hong; Eun Sook Hwang
Journal:  Br J Pharmacol       Date:  2011-06       Impact factor: 8.739

7.  Protective effect of Uncaria tomentosa extract against oxidative stress and genotoxicity induced by glyphosate-Roundup® using zebrafish (Danio rerio) as a model.

Authors:  Glaucia Dal Santo; Alan Grotto; Aline A Boligon; Bárbara Da Costa; Cassiano L Rambo; Emily A Fantini; Elisa Sauer; Luan M V Lazzarotto; Kanandra T Bertoncello; Osmar Tomazelli Júnior; Solange C Garcia; Anna M Siebel; Denis B Rosemberg; Jacir Dal Magro; Greicy M M Conterato; Leila Zanatta
Journal:  Environ Sci Pollut Res Int       Date:  2018-02-13       Impact factor: 4.223

8.  5-Hydroxy-2-(2-phenylethyl)chromone (5-HPEC): a novel non-nitrogenous ligand for 5-HT2B receptor.

Authors:  Dwight A Williams; Saheem A Zaidi; Yan Zhang
Journal:  Bioorg Med Chem Lett       Date:  2014-02-19       Impact factor: 2.823

9.  Cloning and expression analysis of chalcone synthase gene from Coleus forskohlii.

Authors:  Praveen Awasthi; Vidushi Mahajan; Vijay Lakshmi Jamwal; Nitika Kapoor; Shafaq Rasool; Yashbir S Bedi; Sumit G Gandhi
Journal:  J Genet       Date:  2016-09       Impact factor: 1.166

Review 10.  Fibromyalgia syndrome in need of effective treatments.

Authors:  Theoharis C Theoharides; Irene Tsilioni; Lauren Arbetman; Smaro Panagiotidou; Julia M Stewart; Rae M Gleason; Irwin J Russell
Journal:  J Pharmacol Exp Ther       Date:  2015-08-25       Impact factor: 4.030

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