Literature DB >> 23928097

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications.

Hui Wei1, Jingjie Mo1, Li Tao2, Reb J Russell3, Adrienne A Tymiak1, Guodong Chen4, Roxana E Iacob5, John R Engen6.   

Abstract

The higher order structure of protein therapeutics can be interrogated with hydrogen/deuterium exchange mass spectrometry (HDX-MS). HDX-MS is now a widely used tool in the structural characterization of protein therapeutics. In this review, HDX-MS based workflows designed for protein therapeutic discovery and development processes are presented, focusing on the specific applications of epitope mapping for protein/drug interactions and biopharmaceutical comparability studies. Future trends in the application of HDX-MS in protein therapeutics characterization are also described.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23928097      PMCID： PMC4081482          DOI： 10.1016/j.drudis.2013.07.019

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  60 in total

Review 1.  Controlled-release, pegylation, liposomal formulations: new mechanisms in the delivery of injectable drugs.

Authors:  K R Reddy
Journal:  Ann Pharmacother       Date:  2000 Jul-Aug       Impact factor: 3.154

2.  Reducing mass degeneracy in SAR by MS by stable isotopic labeling.

Authors:  C Bailey-Kellogg; J J Kelley; C Stein; B R Donald
Journal:  J Comput Biol       Date:  2001       Impact factor: 1.479

3.  High resolution functional analysis of antibody-antigen interactions.

Authors:  L Jin; B M Fendly; J A Wells
Journal:  J Mol Biol       Date:  1992-08-05       Impact factor: 5.469

4.  Conformational changes in proteins probed by hydrogen-exchange electrospray-ionization mass spectrometry.

Authors:  V Katta; B T Chait
Journal:  Rapid Commun Mass Spectrom       Date:  1991-04       Impact factor: 2.419

5.  An experimental procedure for increasing the structural resolution of chemical hydrogen-exchange measurements on proteins: application to ribonuclease S peptide.

Authors:  J J Rosa; F M Richards
Journal:  J Mol Biol       Date:  1979-09-25       Impact factor: 5.469

6.  Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.

Authors:  A Abuchowski; J R McCoy; N C Palczuk; T van Es; F F Davis
Journal:  J Biol Chem       Date:  1977-06-10       Impact factor: 5.157

Review 7.  Recombinant DNA technology in the treatment of diabetes: insulin analogs.

Authors:  Z Vajo; J Fawcett; W C Duckworth
Journal:  Endocr Rev       Date:  2001-10       Impact factor: 19.871

8.  Molecular epitope identification by limited proteolysis of an immobilized antigen-antibody complex and mass spectrometric peptide mapping.

Authors:  D Suckau; J Köhl; G Karwath; K Schneider; M Casaretto; D Bitter-Suermann; M Przybylski
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

9.  Analysis of protein complexes with hydrogen exchange and mass spectrometry.

Authors:  John R Engen
Journal:  Analyst       Date:  2003-06       Impact factor: 4.616

Review 10.  PEGylated antibodies and antibody fragments for improved therapy: a review.

Authors:  Andrew P Chapman
Journal:  Adv Drug Deliv Rev       Date:  2002-06-17       Impact factor: 15.470
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  68 in total

1.  Conformational Assessment of Adnectin and Adnectin-Drug Conjugate by Hydrogen/Deuterium Exchange Mass Spectrometry.

Authors:  Richard Y-C Huang; Steven R O'Neil; Daša Lipovšek; Guodong Chen
Journal:  J Am Soc Mass Spectrom       Date:  2018-05-07       Impact factor: 3.109

2.  Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis.

Authors:  Jing Li; Hui Wei; Stanley R Krystek; Derek Bond; Ty M Brender; Daniel Cohen; Jena Feiner; Nels Hamacher; Johanna Harshman; Richard Y-C Huang; Susan H Julien; Zheng Lin; Kristina Moore; Luciano Mueller; Claire Noriega; Preeti Sejwal; Paul Sheppard; Brenda Stevens; Guodong Chen; Adrienne A Tymiak; Michael L Gross; Lumelle A Schneeweis
Journal:  Anal Chem       Date:  2017-02-09       Impact factor: 6.986

Review 3.  Probing structures of large protein complexes using zero-length cross-linking.

Authors:  Roland F Rivera-Santiago; Sira Sriswasdi; Sandra L Harper; David W Speicher
Journal:  Methods       Date:  2015-05-01       Impact factor: 3.608

4.  Spin Diffusion Editing for Structural Fingerprints of Therapeutic Antibodies.

Authors:  Joshua Franks; John N Glushka; Michael T Jones; David H Live; Qin Zou; James H Prestegard
Journal:  Anal Chem       Date:  2015-12-22       Impact factor: 6.986

Review 5.  Analytical Aspects of Hydrogen Exchange Mass Spectrometry.

Authors:  John R Engen; Thomas E Wales
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2015-05-29       Impact factor: 10.745

6.  HX-MS2 for high performance conformational analysis of complex protein states.

Authors:  Kyle M Burns; Vladimir Sarpe; Mike Wagenbach; Linda Wordeman; David C Schriemer
Journal:  Protein Sci       Date:  2015-05-29       Impact factor: 6.725

7.  Deciphering Binding Interactions of IL-23R with HDX-MS: Mapping Protein and Macrocyclic Dodecapeptide Ligands.

Authors:  Cristina Sayago; Isabel C Gonzalez Valcarcel; Yuewei Qian; John Lee; Jorge Alsina-Fernandez; Nathan C Fite; Juan J Carrillo; Feiyu F Zhang; Michael J Chalmers; Jeffrey A Dodge; Howard Broughton; Alfonso Espada
Journal:  ACS Med Chem Lett       Date:  2018-08-01       Impact factor: 4.345

8.  Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry.

Authors:  Richard Y-C Huang; Roxana E Iacob; Stanley R Krystek; Mi Jin; Hui Wei; Li Tao; Tapan K Das; Adrienne A Tymiak; John R Engen; Guodong Chen
Journal:  J Am Soc Mass Spectrom       Date:  2016-08-15       Impact factor: 3.109

9.  Mapping a Conformational Epitope of Hemagglutinin A Using Native Mass Spectrometry and Ultraviolet Photodissociation.

Authors:  M Rachel Mehaffey; Jiwon Lee; Jiwon Jung; Michael B Lanzillotti; Edwin E Escobar; Keith R Morgenstern; George Georgiou; Jennifer S Brodbelt
Journal:  Anal Chem       Date:  2020-08-12       Impact factor: 6.986

Review 10.  Mass spectrometry-based methods in characterization of the higher order structure of protein therapeutics.

Authors:  Igor A Kaltashov; Cedric E Bobst; Jake Pawlowski; Guanbo Wang
Journal:  J Pharm Biomed Anal       Date:  2020-02-12       Impact factor: 3.935
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